A kind of oral spray for postoperative care and preparation method thereof

A technology of oral sprays and plant extracts, applied in the field of drug preparation, can solve the problems of short time and slow efficacy of sprays

Active Publication Date: 2021-09-07
南方医科大学第三附属医院(广东省骨科研究院)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The spray can be used to treat stomatitis, and can also be used for antibacterial, but the spray is slow in efficacy and stays in the oral cavity for a short time, making it unsuitable for patients with general anesthesia and intubation

Method used

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  • A kind of oral spray for postoperative care and preparation method thereof
  • A kind of oral spray for postoperative care and preparation method thereof
  • A kind of oral spray for postoperative care and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1, oral spray for postoperative care

[0028] Raw materials containing the following mass percentages: plant extract 0.5%, carboxymethyl yeast dextran 0.5%, tinidazole 0.01%, inorganic salt 0.005%, lemon peel superfine powder 0.05%, polyvinyl alcohol 0.3%, xylitol 0.1% and balance purified water; botanical extracts made from dandelion, honeysuckle vine, saponins and lemon.

[0029] in,

[0030] The mass ratio of dandelion, honeysuckle, saponins and lemon is 1:0.5:0.5:0.2; the inorganic salt is potassium chloride.

[0031] The preparation method of plant extract is:

[0032] A) Take the dandelion, honeysuckle and saponins of the formula, dry and pulverize them, add 15 times the total weight of purified water and ultrasonically extract them for 2 times, each time for 10 minutes, filter, centrifuge, and purify with a ceramic membrane to obtain the filtrate;

[0033] B) peel the lemons of the formula to obtain lemon pulp, squeeze the juice, separate, and take...

Embodiment 2

[0037] Embodiment 2, oral spray for postoperative care

[0038] Raw materials containing the following mass percentages: plant extract 1%, carboxymethyl yeast dextran 0.5%, tinidazole 0.03%, inorganic salt 0.0075%, lemon peel superfine powder 1%, polyvinyl alcohol 2%, xylitol 1% and balance purified water; said plant extracts are made from Dandelion, Honeysuckle, Saponaria thorn and Lemon.

[0039] in,

[0040] The mass ratio of dandelion, honeysuckle, saponins and lemon is 1:1.5:1.5:0.3; the inorganic salts are potassium chloride and magnesium chloride.

[0041] The preparation method of plant extract is:

[0042] A) Take the dandelion, honeysuckle and saponins of the formula, dry and pulverize them, add 15 times the total weight of purified water and ultrasonically extract them for 2 times, each time for 15 minutes, filter, centrifuge, and purify with a ceramic membrane to obtain the filtrate;

[0043] B) peel the lemons of the formula to obtain lemon pulp, squeeze the ...

Embodiment 3

[0047] Embodiment 3, oral spray for postoperative care

[0048] Raw materials containing the following mass percentages: plant extract 1.5%, carboxymethyl yeast dextran 1%, tinidazole 0.06%, inorganic salt 0.01%, preservative 0.2%, lemon peel superfine powder 1%, polyvinyl alcohol 3% %, xylitol 1%, and the balance purified water; plant extracts made from dandelion, honeysuckle vine, saponin thorn and lemon.

[0049] in,

[0050] The mass ratio of dandelion, honeysuckle, saponins and lemon is 1:1.5:1.5:0.5; the inorganic salt is sodium chloride; the preservative is sorbic acid.

[0051] The preparation method of plant extract is:

[0052] A) Take the dandelion, honeysuckle and saponins of the formula, dry and pulverize them, add 15 times the total weight of purified water and ultrasonically extract them for 2 times, each time for 15 minutes, filter, centrifuge, and purify with a ceramic membrane to obtain the filtrate;

[0053] B) peel the lemons of the formula to obtain lem...

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Abstract

The invention belongs to the technical field of medicine preparation, and in particular relates to an oral spray for postoperative care and a preparation method thereof. The oral spray for postoperative care of the present invention comprises the following raw materials in mass percentage: 0.1-1.5% of plant extract, 0.5-1% of carboxymethyl yeast dextran, 0.01-0.06% of tinidazole, 0.005-0.01% of inorganic salt %, preservatives 0-0.2%, lemon peel superfine powder 0.05-1%, polyvinyl alcohol 0.3-3%, xylitol 0.1-1% and the balance of purified water; the plant extract consists of dandelion, honeysuckle, Made with saponins and lemons. The oral spray for post-operative care of the present invention has the effects of relieving thirst and inhibiting bacteria, and can increase the adhesion rate of medicine in the oral cavity and prolong the time of antibacterial action of medicine.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to an oral spray for postoperative care and a preparation method thereof. Background technique [0002] After the operation of patients with general anesthesia and intubation is completed and the endotracheal tube is pulled out, the patients will experience various degrees of discomfort, such as pain, thirst, anxiety, fear, etc. Among them, thirst is the strongest feeling of patients. The physical discomfort caused by thirst increases the patient's stress, increases the patient's oxygen consumption and metabolic burden, and at the same time, the sputum in the mouth has a high viscosity and bacteria multiply rapidly, resulting in an odor in the mouth. At present, in clinical practice, cotton swabs or gauze are often used to moisten the mouth after the patient requests to drink water. However, this method has a limited wetting area and limited thirst relief. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61K9/12A61K47/32A61K47/46A61K47/26A61P1/02A61P31/02A61P31/04A61K31/4164A61K31/716A61K33/14
CPCA61K9/006A61K31/4164A61K31/716A61K33/14A61K36/288A61K36/355A61K36/483A61K36/752A61K47/26A61K47/32A61K47/46A61K2236/31A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P1/02A61P31/02A61P31/04A61K2300/00
Inventor 杨振马化鑫杨春
Owner 南方医科大学第三附属医院(广东省骨科研究院)
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