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Preparation method of Au1Pt3 alloy colloidal solution and electrochemical sensor for detecting dopamine

A colloidal solution and sensor technology, which can be applied to electrochemical variables of materials, scientific instruments, instruments, etc., can solve the problems of scaling on the surface of electrodes, the sensor has no practical application value, and overlap, and achieves simple material preparation, easy popularization, and energy consumption. low effect

Active Publication Date: 2019-12-31
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As an electroactive molecule, DA can directly perform electrocatalysis on the surface of bare glassy carbon electrode (GCE), but the determination of DA content mainly faces two problems: 1) fouling of the electrode surface due to DA oxidation; 2) electrocatalysis of coexisting substances. The catalytic oxidation potential will overlap with the oxidation potential of DA, these factors will cause the sensor to have no practical application value

Method used

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  • Preparation method of Au1Pt3 alloy colloidal solution and electrochemical sensor for detecting dopamine
  • Preparation method of Au1Pt3 alloy colloidal solution and electrochemical sensor for detecting dopamine
  • Preparation method of Au1Pt3 alloy colloidal solution and electrochemical sensor for detecting dopamine

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Experimental program
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Embodiment 1

[0034] A kind of Au 1 Pt 3 The preparation method of alloy colloid solution,

[0035] Put freshly prepared polyvinylpyrrolidone (PVP) and N,N-dimethylacetamide (DMAC) solvent in a flask, stir until PVP is completely dissolved, add n-octanoic acid, sonicate for 2 min, and then chlorine Gold acid (HAuCl 4 ·3H 2 O) and chloroplatinic acid (H 2 PtCl 6 ·12H 2 O) The mixed solution was slowly added dropwise to the flask, ultrasonicated for 4 min, and then pre-prepared sodium borohydride (NaBH) was added. 4 ) solution, stirred at room temperature for 20min, and obtained Au after the end of the reaction 1 Pt 3 Alloy colloid solution.

Embodiment 2

[0037] Put freshly prepared polyvinylpyrrolidone (PVP) and N,N-dimethylacetamide (DMAC) solvent in a flask, stir until PVP is completely dissolved, add n-octanoic acid, sonicate for 1 min, and then chlorine Gold acid (HAuCl 4 ·3H 2 O) and chloroplatinic acid (H 2 PtCl 6 ·12H 2 O) The mixed solution was slowly added dropwise to the flask, the precious metal Au 3+ and Pt 4+ The molar ratio was 1:3, sonicated for 2 min, and then pre-prepared sodium borohydride (NaBH) was added. 4 ) solution, stirred at room temperature for 40 min, and obtained Au after the reaction was completed. 1 Pt 3 Alloy colloid solution.

Embodiment 3

[0039] 1mL freshly prepared 20g·L -1 Polyvinylpyrrolidone (PVP) and 5mL of N,N-dimethylacetamide (DMAC) solvent were placed in a 100mL flask, stirred until PVP was completely dissolved, 50μL of n-octanoic acid was added, sonicated for 1min, followed by 75μL of 0.15 M chloroauric acid (HAuCl 4 ·3H 2 O) with 225 μL of 0.15 M chloroplatinic acid (H 2 PtCl 6 ·12H 2 O) The mixed solution was slowly added dropwise to the flask, sonicated for 2 min, and then 200 μL of pre-prepared sodium borohydride (NaBH) was added. 4 ) solution (0.075g·mL -1 ), stirred at room temperature for 30min, until the end of the reaction to obtain Au 1 Pt 3 Alloy colloid solution.

[0040] In order to better understand the coral-like Au synthesized in the present invention 1 Pt 3 Alloy nanoparticles, which were characterized by transmission electron microscopy and element distribution.

[0041] from figure 2 Coral-like Au can be seen in 1 Pt 3 The alloy nanoparticles have good dispersibility,...

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Abstract

The invention discloses a preparation method of an Au1Pt3 alloy colloidal solution. According to the preparation method, polyvinylpyrrolidone is dissolved in an N, N-dimethylacetamide solvent; stirring is performed until the PVP is completely dissolved, n-caprylic acid is added, an obtained mixture is subjected to ultrasonic treatment; a chloroauric acid / chloroplatinic acid mixed solution is gradually dropwise added into the solution; ultrasonic treatment is carried out; a sodium borohydride solution is added; a reaction is carried out, and a Au1Pt3 alloy colloidal solution is obtained; the alloy colloidal solution is used for preparing Au1Pt3 / GCE at first, methionine is electrochemically polymerized on the surface of the Au1Pt3 / GCE, so that a poly (L-Met) / Au1Pt3 / GCE sensor can be prepared; and the poly (L-Met) / Au1Pt3 / GCE sensor is applied to the qualitative and quantitative electrochemical detection of dopamine. The Au1Pt3 alloy prepared by the method is simple in preparation process;and the Au1Pt3 alloy nanoparticles modifying the surface of a glassy carbon electrode not only improve the electrochemical activity area of the electrode, but also provide a rough surface which facilitates electro-polymerization for L-Met.

Description

technical field [0001] The invention belongs to the preparation technology of electrochemical sensing materials and the research of clinical diagnosis and treatment detection methods, in particular to a kind of coral-like Au 1 Pt 3 The preparation of the alloy and the preparation method of the electroactive small molecule electrochemical sensing material with biocompatibility electropolymerized on its surface are applied to the detection of dopamine (DA) in clinical diagnosis and treatment. Background technique [0002] Dopamine (DA) as a neurotransmitter plays an important role in the mammalian central nervous system and participates in many biochemical processes. Abnormal DA concentration can lead to some neurological disorders and other diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, attention deficit hyperactivity disorder, restless limb syndrome and schizophrenia, etc. The level of DA concentration will directly affect its Individual ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/48G01N27/30G01N27/327
CPCG01N27/48G01N27/308G01N27/3278
Inventor 方国臻张博张萌杜京王硕
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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