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A plant extract composition and its application in sunscreen, after-sun repair, anti-photoaging and whitening cosmetics

A plant extract, post-sun repair technology, applied in the field of natural plant extract compositions, can solve problems such as easy clogging of pores, skin damage, skin allergies, etc., and achieve the effects of reducing inflammatory response, mild skin effect, and low production cost

Active Publication Date: 2021-12-24
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Physical sunscreens such as titanium dioxide and zinc oxide can effectively shield the skin from ultraviolet rays, but when used in large amounts or for a long time, the air permeability is poor and pores are easily blocked; chemical sunscreens such as benzophenone derivatives are also widely used. However, because it is easy to cause skin allergies and photolysis reactions, etc., the intermediate products produced by long-term use are easy to cause damage to the skin.

Method used

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  • A plant extract composition and its application in sunscreen, after-sun repair, anti-photoaging and whitening cosmetics
  • A plant extract composition and its application in sunscreen, after-sun repair, anti-photoaging and whitening cosmetics
  • A plant extract composition and its application in sunscreen, after-sun repair, anti-photoaging and whitening cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1. Effects of rosemary extract, honeysuckle extract, and Chuanxiong extract on cell activity.

[0043] Immortalized human epidermal HaCaT cells were used at 1×10 5 The density of each well was inoculated into a 96-well plate. After the cells adhered to the wall, the original cell culture medium was replaced with 100 μL of 1640 medium containing drugs. Respectively (0mg / mL, 0.25mg / mL, 0.5mg / mL, 0.75mg / mL, 1mg / mL, 1.5mg / mL, 2mg / mL). After 24 hours, add CCK-8 to detect the proliferation activity of the cells. Add 10 μl of CCK-8 solution to each well, and incubate in a 37°C incubator for 1 hour, and the color of the medium turns orange; the specific incubation time depends on different cells, and the detection wavelength is the absorbance value at 450nm, the higher the absorbance value, the greater the proliferative activity of the cells, and vice versa. The result is as Picture 1-1 , 1-2, 1-3, compared with the control group without drugs, when the concentratio...

Embodiment 2

[0044] Example 2. Comparison of the protective effects of the composition, rosemary extract, and honeysuckle extract on UV-irradiated HaCaT cells.

[0045] Immortalized human epidermal HaCaT cells were used at 1×10 5 The density of each hole was inoculated into a 96-well plate. After the cells adhered to the wall, the original cell culture medium was replaced with 100 μL of 1640 medium containing drugs. Experimental groups: control group, ultraviolet group, composition group (containing 0.25mg / mL rosemary extract and 0.25mg / mL honeysuckle extract), rosemary extract group (0.25mg / mL, 0.5mg / mL), honeysuckle extract group (0.25mg / mL, 0.5mg / mL). After the drug was incubated for 24 hours, the drug medium was replaced with PBS and irradiated by a cell sunlight ultraviolet simulator (purchased from France) at a dose of 50 mJ / cm 2 UVB+550mJ / cm 2 UVA, in which the cells in the experimental control group were neither treated with drugs nor irradiated with UVA. After the end of ultra...

Embodiment 3

[0046] Example 3. Comparison of the protective effect of the composition, rosemary extract, and Chuanxiong extract on UV-irradiated HaCaT cells.

[0047] The implementation process refers to Example 2, experimental grouping: control group, ultraviolet group, composition group (containing 0.25mg / mL rosemary extract and 0.25mg / mL Chuanxiong extract), rosemary extract group (0.25mg / mL mL, 0.5mg / mL), Chuanxiong extract group (0.25mg / mL, 0.5mg / mL). The result statistics are as follows image 3 shown. The activity of HaCaT cells after ultraviolet irradiation was significantly reduced, and semi-lethal phenomenon appeared. After adding the composition, rosemary, and Chuanxiong extracts, the cell activity was enhanced. Compared with the UV control group, the difference was significant and statistically significant, * *p<0.01, ***p<0.001, compared with the rosemary extract group and Chuanxiong extract group, the cell viability increased significantly in the composition group, the diff...

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Abstract

The invention discloses the application of a natural plant rosemary, honeysuckle and chuanxiong extract composition in sun protection, after-sun repair, anti-inflammation, anti-photoaging and whitening cosmetics, belonging to the field of traditional Chinese medicine and cosmetics. The present invention applies the extracts of rosemary, honeysuckle and chuanxiong to cosmetics, and it is verified that the combination of two or three components can effectively resist the damage caused by ultraviolet rays to the skin, and has an obvious effect on the repair of skin cells after ultraviolet rays , the present invention finds for the first time that the combined use of the components in the composition can significantly improve the sun protection effect, repair effect after sun exposure, has anti-inflammatory, anti-photoaging and whitening effects, can keep the skin moist, and increase the moisture content of the skin after sun exposure And the role of skin elasticity, safe and stable use. The combination of plant extracts of the present invention with functions of sun protection, post-sun repair, anti-inflammation, anti-photoaging and whitening effects can be used as effective active ingredients to make creams, sprays, powders and other dosage forms for use in cosmetics.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and cosmetics, and relates to a natural plant extract composition containing rosemary extract, honeysuckle extract and / or Rhizoma Chuanxiong composition and its effects in sun protection, after-sun repair, anti-inflammation, anti-photoaging and Application in whitening cosmetics. Background technique [0002] In recent years, the increase in natural environmental pollution and atmospheric damage has led to an increase in the ultraviolet rays irradiating the ground, and the number of patients with skin aging, solar dermatitis and even skin cancer has increased significantly. Therefore, it is necessary to look for safe, effective and stable cosmetic sunscreens and sunscreens. The post-restoration agent has always been the focus of many researchers. [0003] Among the three types of ultraviolet rays in different wavelength ranges, two parts of ultraviolet rays can be irradiated to the gro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61Q17/04A61Q19/02A61Q19/08A61Q19/00
CPCA61K8/9789A61Q17/04A61Q19/004A61Q19/02A61Q19/08A61Q19/00A61K2800/5922
Inventor 叶希韵周艳卿尹尉翰刘明耀
Owner EAST CHINA NORMAL UNIV
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