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Mussel-imitated underwater high-viscosity hydrogel preparation method

A hydrogel and high-viscosity technology, which is applied in the field of preparation of underwater high-viscosity hydrogel, can solve problems such as adhesion and poor biocompatibility, and achieve increased underwater adhesion, good biocompatibility, and water Obvious effect under the adhesion effect

Inactive Publication Date: 2020-01-14
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows for easy production of hydrogels that have excellent properties such as being able to stick easily into different types of aqueous environments like sea or river waters without losing their integrity over long periods of use (up to several months). These hydrates also work well when placed near hard surfaces due to its high strength against pressure) making them ideal candidates for applications where strong bonds between substrates must occur frequently during medical procedures.

Problems solved by technology

The technical problem addressed in this patented technology relates to improving the strength of hydrogel materials that resist water absorption when exposed to humid conditions for use in different applications such as medicine or tissue engineering.

Method used

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Examples

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Effect test

Embodiment 1

[0028] A preparation method of an underwater high-viscosity hydrogel imitating mussels, the preparation method comprising the following steps:

[0029] 1) Dissolve 1g chitosan in 50mL acetic acid (2%, v / v) to make chitosan acetic acid solution;

[0030] 2) Add 0.95g HCA, 0.95g EDC, 0.58g NHS to the solution prepared in step (1), adjust the pH to 5, and react for 10 hours;

[0031] 3) Transfer the solution obtained in step (2) to a dialysis zone with a molecular cut-off of 3500KDa, dialyze in water with pH=5 for 2 days, take the retentate and freeze-dry it for 48 hours to obtain catechol-grafted chitosan ;

[0032] 4) Dissolving 0.25 g of catechol-grafted chitosan obtained in step (3) in 10 mL of water;

[0033] 5) Dissolve 1g of dextran in 50mL of water to make an aqueous solution of dextran;

[0034] 6) Add 0.825g of sodium periodate to the solution prepared in step (5), and add 1mL of ethylene glycol to terminate the reaction after 6 hours of dark reaction;

[0035] 7) T...

Embodiment 2

[0039] A preparation method of an underwater high-viscosity hydrogel imitating mussels, the preparation method comprising the following steps:

[0040] 1) Dissolve 2g chitosan in 100mL acetic acid (2%, v / v) to make chitosan acetic acid solution;

[0041] 2) Add 1.9g HCA, 1.9g EDC, 1.16g NHS to the solution prepared in step (1), adjust the pH to 5, and react for 10 hours;

[0042] 3) Transfer the solution obtained in step (2) to a dialysis zone with a molecular cut-off of 10,000 KDa, dialyze in water with pH=5 for 2 days, take the retentate and freeze-dry it for 24 hours to obtain catechol-grafted chitosan ;

[0043] 4) Dissolving 0.25 g of catechol-grafted chitosan obtained in step (3) in 10 mL of water;

[0044] 5) Dissolve 1g of dextran in 50mL of water to make an aqueous solution of dextran;

[0045] 6) Add 0.825g of sodium periodate to the solution prepared in step (5), and add 1mL of ethylene glycol to terminate the reaction after 10 hours of dark reaction;

[0046] 7...

Embodiment 3

[0050] A preparation method of an underwater high-viscosity hydrogel imitating mussels, the preparation method comprising the following steps:

[0051] 1) Dissolve 2g chitosan in 100mL acetic acid (2%, v / v) to make chitosan acetic acid solution;

[0052] 2) Add 1.9g HCA, 1.9g EDC, 1.16g NHS to the solution prepared in step (1), adjust the pH to 5, and react for 10 hours;

[0053] 3) Transfer the solution obtained in step (2) to a dialysis zone with a molecular cut-off of 14,000 KDa, dialyze in water with pH=5 for 3 days, take the retentate and freeze-dry it for 48 hours to obtain catechol-grafted chitosan ;

[0054] 4) Dissolving 0.3 g of catechol-grafted chitosan obtained in step (3) in 10 mL of water;

[0055] 5) Dissolve 1g of dextran in 50mL of water to make an aqueous solution of dextran;

[0056] 6) Add 0.825g of sodium periodate to the solution prepared in step (5), and react in the dark for 12 hours, then add 1mL of ethylene glycol to terminate the reaction;

[005...

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Abstract

The invention discloses a mussel-imitated underwater high-viscosity hydrogel preparation method, which comprises: (1) dissolving chitosan in acetic acid to prepare a chitosan acetic acid solution; (2)adding 3,4-dihydroxyphenylacetic acid, EDC and NHS into the solution prepared in the step (1), adjusting the pH value, and carrying out a reaction for a certain time; (3) dialyzing the solution obtained in the step (2) in water with the pH value of 5, taking the trapped fluid, and carrying out freeze-drying; (4) preparing the sample obtained in the step (3) into a solution; (5) dissolving glucanin water, adding an oxidant, reacting for a certain time in a dark place, and then adding ethylene glycol to terminate the reaction; (6) dialyzing the solution obtained in the step (5) in water, taking the trapped fluid, and carrying out freeze-drying; (7) preparing the sample obtained in the step (6) into a solution; and (8) mixing the solutions obtained in the step (4) and the step (7) to obtainthe hydrogel. According to the preparation method provided by the invention, the prepared hydrogel can be used as an underwater adhesive.

Description

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Claims

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Application Information

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Owner SOUTHEAST UNIV
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