A kind of sustained-release chemotherapeutic particle and its preparation method and application

A microparticle and slow-release technology, applied in the direction of microcapsules, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of high price, dosage and cycle restrictions, toxic and side effects, etc., and achieve easy access and bone marrow suppression Light, reduce the effect of side effects

Active Publication Date: 2022-07-08
文黎明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Some chemotherapy drugs have serious toxic and side effects on the normal tissues of the body, so the dosage and cycle of the drug are limited
While other drugs with less toxic and side effects are often too expensive and unbearable for ordinary patients.

Method used

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  • A kind of sustained-release chemotherapeutic particle and its preparation method and application
  • A kind of sustained-release chemotherapeutic particle and its preparation method and application
  • A kind of sustained-release chemotherapeutic particle and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0031] A method for preparing slow-release chemotherapeutic particles provided by a preferred embodiment of the present invention comprises the following steps:

[0032] S1. Dissolve polycaprolactone in dichloromethane with a concentration of 0.1 g / mL, and then add 10 wt% of cisplatin powder in the total solution; perform high-voltage electrospinning on the obtained solution to obtain nanofiber cores loaded with chemotherapeutic drugs Among them, the high-voltage electrospinning conditions are: the power supply voltage is 14kV, the distance between the needle and the receiving substrate is 14cm, the feeding speed of the outer layer is 0.7mL / h, and the inner layer is 2.5mL / h;

[0033] S2. Dissolve 1 g of chitosan in 40 mL of 2wt% acetic acid solution, add 18 mL of 2wt% glutaraldehyde, stir at a constant temperature at 50°C for 3h, and let stand for 24h to obtain a chitosan hydrogel solution;

[0034] S3. Soak the chemotherapeutic drug-loaded nanofiber cores obtained in step S1 ...

Embodiment 2

[0037] A method for preparing slow-release chemotherapeutic particles provided by a preferred embodiment of the present invention comprises the following steps:

[0038] S1. Dissolve polycaprolactone in dichloromethane at a concentration of 0.15 g / mL, and then add paclitaxel powder accounting for 20 wt% of the total solution; perform high-voltage electrospinning on the obtained solution to obtain a chemotherapeutic drug-loaded nanofiber core ; Among them, the high-voltage electrospinning conditions are: the power supply voltage is 14kV, the distance between the needle and the receiving substrate is 14cm, the feeding speed of the outer layer is 0.7mL / h, and the inner layer is 2.5mL / h;

[0039] S2. Dissolve 1 g of chitosan in 42 mL of 2wt% acetic acid solution, add 16 mL of 2wt% glutaraldehyde, stir at a constant temperature at 50°C for 3h, and let stand for 24h to obtain a chitosan hydrogel solution;

[0040] S3. Immerse the chemotherapeutic drug-loaded nanofiber cores obtained...

Embodiment 3

[0043] A method for preparing slow-release chemotherapeutic particles provided by a preferred embodiment of the present invention comprises the following steps:

[0044] S1. Dissolve polycaprolactone in dichloromethane with a concentration of 0.1 g / mL, then add doxorubicin powder accounting for 15 wt% of the total solution; perform high-voltage electrospinning on the obtained solution to obtain nanofibers loaded with chemotherapeutic drugs Core; among them, the high-voltage electrospinning conditions are: the power supply voltage is 14kV, the distance between the needle and the receiving substrate is 14cm, the feeding speed is 0.7mL / h for the outer layer, and 2.5mL / h for the inner layer;

[0045] S2. Dissolve 1 g of chitosan in 38 mL of a 2wt% acetic acid solution, add 16 mL of 2wt% glutaraldehyde, stir at a constant temperature at 50°C for 3 hours, and let stand for 24 hours to obtain a chitosan hydrogel solution;

[0046] S3. Soak the chemotherapeutic drug-loaded nanofiber c...

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Abstract

The invention discloses a slow-release chemotherapeutic particle and a preparation method and application thereof. The core structure is prepared by a coaxial electrospinning method, and then soaked in a chitosan gel, and finally the shell layer structure is prepared by a film dispersion method. , to obtain sustained-release chemotherapeutic particles. The sustained-release chemotherapeutic particles prepared by the invention have the characteristics of easy acquisition of raw materials, strong controllability and easy large-scale industrial production. The sustained-release chemotherapeutic particles prepared by the invention are used for chemotherapy, and the sustained-release microspheres have good sustained-release effect, can reduce the toxic and side effects on normal tissues, and can continuously exert anti-tumor effects for a long time.

Description

technical field [0001] The invention belongs to the technical field of chemotherapeutic drugs, in particular to a slow-release chemotherapeutic particle and a preparation method and application thereof. Background technique [0002] For patients with intermediate and advanced cancer, the constitution is generally weak, and the indications for surgery are often lost, and intensive radiotherapy and chemotherapy cannot be used. Sustained-release chemotherapeutic particles are implanted with high local concentration and mild local inflammatory reaction, without cell degeneration, necrosis and other adverse reactions. It is a minimally invasive, high-efficiency and low-toxicity method, which improves the quality of life of patients and prolongs survival. Expect. [0003] Due to the serious toxic and side effects of some chemotherapy drugs on the normal tissues of the body, the dosage and period of the drugs are limited. While other drugs with less toxic and side effects are oft...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K47/36A61K47/34A61K45/00A61P35/00
CPCA61K9/5036A61K47/34A61K45/00A61P35/00
Inventor 文黎明李林艳杨亚玲曹耀丹
Owner 文黎明
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