Methods for treating hyperlipidemia in diabetic patients by administering a pcsk9 inhibitor
A technology for type 1 diabetes and hypercholesterolemia, which is applied in the field of diabetic patients and can solve the problems of incomplete understanding of the efficacy and safety of alirixumab
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0344] Example 1: Generation of human antibodies against human PCSK9
[0345] Human anti-PCSK9 antibodies were generated as described in US Patent No. 8,062,640. An exemplary PCSK9 inhibitor used in the following examples is the human anti-PCSK9 antibody designated "mAb316P", also known as "REGN727" or "alirocumab". mAb316P has the following amino acid sequence characteristics: a heavy chain comprising SEQ ID NO:5 and a light chain comprising SEQ ID NO:9; a heavy chain variable region (HCVR) comprising SEQ ID NO:1 and a heavy chain comprising SEQ ID NO:6 Light chain variable region (LCVR); heavy chain complementarity determining region 1 (HCDR1) comprising SEQ ID NO:2, HCDR2 comprising SEQ ID NO:3, HCDR3 comprising SEQ ID NO:4, comprising SEQ ID NO:7 Light chain complementarity determining region 1 (LCDR1), LCDR2 comprising SEQ ID NO:8 and LCDR3 comprising SEQ ID NO:10.
Embodiment 2
[0346] Example 2: Randomized, double-blind, placebo-controlled parallel group study to evaluate alirixumab in patients with type 1 or type 2 diabetes mellitus not adequately controlled on maximally tolerated LDL-C lowering therapy Efficacy and safety of insulin-treated patients with hypercholesterolemia at high cardiovascular risk
[0347] introduce
[0348] More than 380 million people worldwide live with diabetes, most of whom will die from cardiovascular disease (CVD). Compared with people without diabetes, those with diabetes are at higher risk of developing CVD, suffer from associated clinical complications and at an earlier age, and have a shortened life expectancy of about 6 to 7 years. In addition to the high in-person costs of the disease, CVD contributes significantly to the overall healthcare expenditure of these patients.
[0349] The study, named Odyssey DM-Insulin, included adult patients with type 1 or type 2 diabetes on insulin therapy who, with or without ot...
Embodiment 3
[0739] Example 3: Analysis of Individuals with Type 2 Diabetes and ASCVD from the Odyssey DM-Insulin Clinical Trial
[0740] Individuals with diabetes often have high levels of atherogenic lipoproteins and cholesterol, which consist of low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B (ApoB) and low-density lipoprotein particle number (LDL-PN) reflected. The presence of atherosclerotic cardiovascular disease (ASCVD) increases the risk of future cardiovascular events.
[0741] In this analysis, we assessed the efficacy and safety of alirocumab in individuals with T2DM, high LDL-C, or non-HDL-C, and identified patients receiving maximally tolerated statins in the DM-insulin study. Class ASCVD. DM-insulin study participants with ASCVD and T1DM were not included in this analysis because of the low number of individuals in this group (alicumab: n=11; placebo: n=5). As used in this example, ASCVD was defined as cor...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com