Baicalein metal complex prepared by ore coagulation method and preparation method of preparation thereof

A technology of metal complexes and baicalein, which is applied in the field of preparation of baicalein metal complexes and their preparations by ore coagulation method, can solve the problems of high consumption of organic reagents, difficulty in passing approval, and high equipment requirements, and achieve protection The environment, the preparation method are simple and easy, and the effect of high content

Inactive Publication Date: 2020-04-14
武汉回盛生物科技股份有限公司
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  • Description
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  • Application Information

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Problems solved by technology

[0009] Aiming at the deficiencies in the prior art, the present invention provides a preparation method for preparing baicalein metal complexes and preparations thereof by the ore coagulation method, which solves the problems of large consumption of organic reagents and high energy consumption in the existing preparat

Method used

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  • Baicalein metal complex prepared by ore coagulation method and preparation method of preparation thereof
  • Baicalein metal complex prepared by ore coagulation method and preparation method of preparation thereof
  • Baicalein metal complex prepared by ore coagulation method and preparation method of preparation thereof

Examples

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Example Embodiment

[0036] Example 1 A method for preparing baicalein metal complex by ore coagulation method, the steps are as follows:

[0037] (1) Put 100g of Scutellaria baicalensis pieces into 800g40(v / v)% ethanol solution and soak (60℃) twice (the second time is 800g, the same below), each time for 1.5 hours, combine the warm soaking solution, reduce After pressing and concentrating until the alcohol content is determined to be zero, the concentrated solution A is obtained, which is kept at 60°C for later use;

[0038] (2) Take 4g each of ore-type traditional Chinese medicine bile alum and alum, decoct them with purified water twice, each time with 80g purified water to obtain decoction B;

[0039] (3) After mixing the decoction liquid B and the concentrated liquid A according to the mass ratio of 1:20, the precipitate is filtered, washed with purified water for 3 times and then dried to obtain the baicalein metal complex with a mass of 19.93 g.

[0040] For the determination of the content of the ...

Example Embodiment

[0041] Example 2 A method for preparing baicalein metal complex by ore coagulation method, the steps are as follows:

[0042] (1) Put 100g of scutellaria baicalensis pieces into 800g50(v / v)% ethanol solution and warm immersion (60℃) twice for 1.5 hours each time. Combine the warm immersion liquid and concentrate under reduced pressure until the alcohol content measurement count is zero. Concentrate A, keep it at 60℃ for later use;

[0043] (2) Take 4g each of ore-type traditional Chinese medicine saponin and calamine, decoct twice, each with 80g purified water, to obtain decoction B;

[0044] (3) The decoction liquid B and the concentrated liquid A were mixed according to the mass ratio of 1:30, and the precipitate was filtered out, washed with purified water for 3 times and dried to obtain the baicalein metal complex, with a mass of 19.72 g.

[0045] For the determination of the content of the baicalein metal complex, see image 3 The content is 47.25% calculated by baicalin, and the...

Example Embodiment

[0046] Example 3 A preparation method for preparing baicalein metal complex by ore coagulation method, the steps are as follows:

[0047] (1) Put 100g of scutellaria baicalensis pieces into 800g50(v / v)% ethanol solution and warm immersion (60℃) twice for 1.5 hours each time. Combine the warm immersion liquid and concentrate under reduced pressure until the alcohol content measurement count is zero. Concentrate A, keep it at 60℃ for later use;

[0048] (2) Take 8 g of calamine and decoct twice, each time with 80 g of purified water to obtain decoction B;

[0049] (3) The decoction liquid B and the concentrated liquid A are mixed according to the mass ratio of 1:40, and the precipitate is filtered out, washed with purified water for 3 times and dried to obtain the baicalein metal complex with a mass of 20.27 g.

[0050] For the determination of the content of the baicalein metal complex, see Figure 4 The content is 46.46% calculated by baicalin, and the extraction rate is 97.09%.

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Abstract

The invention belongs to the technical field of veterinary traditional Chinese medicine preparations, and particularly discloses a baicalein metal complex prepared by an ore coagulation method and a preparation method of a preparation thereof. The method comprises the following steps: taking scutellaria baicalensis decoction pieces, carrying out warm soaking by using an ethanol solution with a certain concentration, carrying out vacuum concentration on the warm soaking liquid to obtain a concentrated solution A, and insulating for later use; taking one or more than two of mineral traditional Chinese medicines including chalcanthite, alumen, melanterite, calamine, ochre and red halloysite, and decocting to obtain a decoction B; and mixing the decoction B and the concentrated solution A according to a certain ratio, filtering to obtain a precipitate, washing the precipitate with purified water to obtain a baicalein metal complex, and respectively crushing, sieving, mixing and drying thecomplex and auxiliary materials to obtain a baicalein metal complex solid preparation. The baicalein metal complex is prepared from the traditional Chinese medicine scutellaria baicalensis according to the colloid coagulation principle of mineral traditional Chinese medicines, the content of the obtained baicalein metal complex is high, the used raw materials are traditional Chinese medicines, thesteps are simple and environmentally friendly and facilitate industrial production, the baicalein metal complex is applied to the field of veterinary medicine, and a new method and thought are provided for green breeding.

Description

technical field [0001] The invention belongs to the technical field of veterinary traditional Chinese medicine pharmacy, and specifically discloses a method for preparing a baicalein metal complex and a preparation thereof by an ore coagulation method. Background technique [0002] Scutellaria baicalensis is a commonly used traditional Chinese medicine. It is the dried root of Scutellaria baicalensis, a plant in the Labiatae family. It contains baicalin, baicalein, wogonin and wogonin. Pharmacological studies have shown that baicalein has pharmacological effects such as antibacterial and anti-inflammatory, antihypertensive and diuretic, scavenging superoxide free radicals, and inhibiting lipase. Sun Jinyu, Wu You, et al. Synthesis, characterization and antioxidant activity of Al(Ⅲ)-luteolin and baicalein complexes[J]. Journal of Sichuan University: Engineering Science Edition, 2016, 48(1): 215; Lian Lin Wang. Synthesis, characterization and in vitro biological activity of b...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/14A61P29/00A61P39/06A61K33/06A61K33/26A61K33/30A61K33/34
CPCA61K9/145A61K9/146A61K33/06A61K33/26A61K33/30A61K33/34A61K36/539A61K2236/331A61P29/00A61P39/06A61K2300/00
Inventor 张卫元范琦杨新李亚威王海坤李硕
Owner 武汉回盛生物科技股份有限公司
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