Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Baicalein metal complex prepared by ore coagulation method and preparation method of preparation thereof

A technology of metal complexes and baicalein, which is applied in the field of preparation of baicalein metal complexes and their preparations by ore coagulation method, can solve the problems of high consumption of organic reagents, difficulty in passing approval, and high equipment requirements, and achieve protection The environment, the preparation method are simple and easy, and the effect of high content

Inactive Publication Date: 2020-04-14
武汉回盛生物科技股份有限公司
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the deficiencies in the prior art, the present invention provides a preparation method for preparing baicalein metal complexes and preparations thereof by the ore coagulation method, which solves the problems of large consumption of organic reagents and high energy consumption in the existing preparation methods. question
The raw materials used in the present invention are the combination of Chinese medicinal materials for reaction, which solves the problems of high equipment requirements, cumbersome process of chemical synthesis methods, difficulty in preparing Chinese medicine and chemical medicine together, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Baicalein metal complex prepared by ore coagulation method and preparation method of preparation thereof
  • Baicalein metal complex prepared by ore coagulation method and preparation method of preparation thereof
  • Baicalein metal complex prepared by ore coagulation method and preparation method of preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 A kind of ore coagulation method prepares the preparation method of baicalein metal complex, the steps are as follows:

[0037] (1) Put 100g of Scutellaria baicalensis slices into 800g 40 (v / v)% ethanol solution and warm soak (60°C) twice (the amount of ethanol solution for the second time is also 800g, the same below), each time for 1.5 hours, combine the warm soak solution, reduce Concentrate under pressure until the counting number of the alcohol content measurement is zero to obtain the concentrated solution A, which is kept at 60°C for later use;

[0038] (2) Get each 4g of ore class traditional Chinese medicine gall alum and alum, decoct twice with purified water, each 80g purified water, get decoction B;

[0039] (3) After mixing the decoction solution B and the concentrated solution A according to the mass ratio of 1:20, filter the precipitate, wash the precipitate with purified water 3 times and dry to obtain the baicalein metal complex with a mass...

Embodiment 2

[0041] Embodiment 2 A kind of ore coagulation method prepares the preparation method of baicalein metal complex, and the steps are as follows:

[0042] (1) put 100g of Scutellaria baicalensis pieces into 800g of 50 (v / v)% ethanol solution and warm soak (60°C) for 2 times, each time for 1.5 hours, combine the warm soak liquid, concentrate under reduced pressure until the counting number of alcohol content determination is zero, and obtain Concentrate A, keep warm at 60°C for later use;

[0043] (2) get each 4g of ore class traditional Chinese medicine soap alum and calamine, decoct twice, each 80g purified water, get decoction B;

[0044] (3) Mix the decoction B and the concentrated solution A according to the mass ratio of 1:30, then filter to collect the precipitate, wash the precipitate with purified water 3 times and dry to obtain the baicalein metal complex with a mass of 19.72 g.

[0045] The obtained baicalein metal complex content assay spectrum is shown in image 3 ,...

Embodiment 3

[0046] Embodiment 3 A kind of ore coagulation method prepares the preparation method of baicalein metal complex, the steps are as follows:

[0047] (1) put 100g of Scutellaria baicalensis pieces into 800g of 50 (v / v)% ethanol solution and warm soak (60°C) for 2 times, each time for 1.5 hours, combine the warm soak liquid, concentrate under reduced pressure until the counting number of alcohol content determination is zero, and obtain Concentrate A, keep warm at 60°C for later use;

[0048] (2) Get 8 g of calamine, decoct twice, each time with 80 g of purified water, to obtain decoction B;

[0049] (3) Mix the decoction B and concentrated solution A according to the mass ratio of 1:40, then filter the precipitate, wash the precipitate with purified water 3 times and dry to obtain the baicalein metal complex with a mass of 20.27 g.

[0050] The obtained baicalein metal complex content assay spectrum is shown in Figure 4 , the content calculated by baicalin is 46.46%, and the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of veterinary traditional Chinese medicine preparations, and particularly discloses a baicalein metal complex prepared by an ore coagulation method and a preparation method of a preparation thereof. The method comprises the following steps: taking scutellaria baicalensis decoction pieces, carrying out warm soaking by using an ethanol solution with a certain concentration, carrying out vacuum concentration on the warm soaking liquid to obtain a concentrated solution A, and insulating for later use; taking one or more than two of mineral traditional Chinese medicines including chalcanthite, alumen, melanterite, calamine, ochre and red halloysite, and decocting to obtain a decoction B; and mixing the decoction B and the concentrated solution A according to a certain ratio, filtering to obtain a precipitate, washing the precipitate with purified water to obtain a baicalein metal complex, and respectively crushing, sieving, mixing and drying thecomplex and auxiliary materials to obtain a baicalein metal complex solid preparation. The baicalein metal complex is prepared from the traditional Chinese medicine scutellaria baicalensis according to the colloid coagulation principle of mineral traditional Chinese medicines, the content of the obtained baicalein metal complex is high, the used raw materials are traditional Chinese medicines, thesteps are simple and environmentally friendly and facilitate industrial production, the baicalein metal complex is applied to the field of veterinary medicine, and a new method and thought are provided for green breeding.

Description

technical field [0001] The invention belongs to the technical field of veterinary traditional Chinese medicine pharmacy, and specifically discloses a method for preparing a baicalein metal complex and a preparation thereof by an ore coagulation method. Background technique [0002] Scutellaria baicalensis is a commonly used traditional Chinese medicine. It is the dried root of Scutellaria baicalensis, a plant in the Labiatae family. It contains baicalin, baicalein, wogonin and wogonin. Pharmacological studies have shown that baicalein has pharmacological effects such as antibacterial and anti-inflammatory, antihypertensive and diuretic, scavenging superoxide free radicals, and inhibiting lipase. Sun Jinyu, Wu You, et al. Synthesis, characterization and antioxidant activity of Al(Ⅲ)-luteolin and baicalein complexes[J]. Journal of Sichuan University: Engineering Science Edition, 2016, 48(1): 215; Lian Lin Wang. Synthesis, characterization and in vitro biological activity of b...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/539A61K9/14A61P29/00A61P39/06A61K33/06A61K33/26A61K33/30A61K33/34
CPCA61K9/145A61K9/146A61K33/06A61K33/26A61K33/30A61K33/34A61K36/539A61K2236/331A61P29/00A61P39/06A61K2300/00
Inventor 张卫元范琦杨新李亚威王海坤李硕
Owner 武汉回盛生物科技股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com