Fluorine-containing thiophene derivative 3-(N-trifluoroacetamido)thiophene, and synthesis method and application thereof

A technology of trifluoroacetamido and thiophene derivatives, applied in coatings, organic chemistry, etc., can solve problems such as poor anti-ultraviolet performance, easy yellowing and aging, and achieve low water vapor transmission and anti-yellowing ability Strong, good hydrophobic effect

Active Publication Date: 2020-04-17
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, PVDC emulsions and composites coated with PVDC emulsions have poor UV resistance, and are prone to yellowing and aging under l

Method used

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  • Fluorine-containing thiophene derivative 3-(N-trifluoroacetamido)thiophene, and synthesis method and application thereof
  • Fluorine-containing thiophene derivative 3-(N-trifluoroacetamido)thiophene, and synthesis method and application thereof
  • Fluorine-containing thiophene derivative 3-(N-trifluoroacetamido)thiophene, and synthesis method and application thereof

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Embodiment 1

[0019] The preparation process of 3-(N-trifluoroacetylamino)thiophene of the present invention is:

[0020] 9.92g (0.1mol) 3-aminothiophene oxalate is dissolved in 128ml (2mol) methylene chloride solution, under the effect of 25.30g (0.25mol) triethylamine, obtains the 3-aminothiophene of free state, then will The reaction solution was cooled to 0°C, and 25.2 g (0.12 mol) of trifluoroacetic anhydride was slowly added dropwise. After reacting at room temperature for 2 hours, a saturated sodium bicarbonate solution was added until no bubbles were generated to obtain a mixed solution;

[0021] The mixed solution after the above reaction was extracted 3 times with ethyl acetate, and the organic phases were combined, and the organic phase was washed 3 times with saturated sodium chloride solution, dried by adding anhydrous sodium sulfate, suction filtered, and the solvent was rotary evaporated to obtain 3-( Crude N-trifluoroacetylamino)thiophene. The obtained 3-(N-trifluoroacetyla...

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Abstract

The invention discloses a fluorine-containing thiophene derivative 3-(N-trifluoroacetamido)thiophene, and a synthesis method and an application thereof. The 3-(N-trifluoroacetamido)thiophene is represented by formula 1 shown in the description. The preparation method comprises the following steps: dissolving 3-aminothiophene oxalate into dichloromethane, performing a reaction under the action of triethylamine to obtain free 3-aminothiophene, then cooling the reacted solution to 0 DEG C, slowly dropwise adding trifluoroacetic anhydride, reacting at room temperature for 8-10 h, then adding a saturated sodium bicarbonate solution until no bubble is generated in order to obtain a reacted mixed solution, and separating and purifying to obtain 3-(N-trifluoroacetamido)thiophene, wherein the massratio of the 3-aminothiophene oxalate to the triethylamine to the trifluoroacetic anhydride is 1:(1-5):(1-3). The 3-(N-trifluoroacetamido)thiophene disclosed by the invention is applied to preparationof a composite emulsion.

Description

technical field [0001] The invention relates to a synthesis method of 3-(N-trifluoroacetylamino)thiophene and its fluorine-containing thiophene derivatives and their application as additives for polymer emulsions. Background technique [0002] Polyvinylidene chloride (PVDC) polymer material has a good ability to block water vapor and oxygen, and is widely used in packaging fields such as food preservation film and pharmaceutical packaging materials. At present, PVDC emulsion is widely used in the field of food and pharmaceutical packaging. Coating PVDC emulsion on PVC, PET, PCT and other materials can significantly improve the barrier properties of these materials. However, PVDC emulsions and composites coated with PVDC emulsions have poor UV resistance, and are prone to yellowing and aging under long-term sunlight exposure. Therefore, it is necessary to study suitable additives to further improve the performance of PVDC emulsions. Contents of the invention [0003] The t...

Claims

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Application Information

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IPC IPC(8): C07D333/36C09D7/63C09D127/08
CPCC07D333/36C09D127/08C09D7/63C08K5/45
Inventor 吕耀康王虎李建杭杨德明
Owner ZHEJIANG UNIV OF TECH
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