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Methods to improve organ viability

A viability, organ technology, applied in the field of improving organ viability

Pending Publication Date: 2020-05-05
MALLINCKRODT HOSPITAL PRODUCTS IP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such methods cannot be relied upon for long periods of time, and the success of organ transplantation and limb reattachment remains inversely proportional to the time it takes for the organ or limb to detach from the intact organism

Method used

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  • Methods to improve organ viability
  • Methods to improve organ viability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Example 1: Lung Transplant Protocol

[0077] A total of 20 lungs (8 lungs with gNO and perfusate, 8 lungs with perfusate only, and 4 lungs with ventilated gNO and perfusate) were included in the study according to modified standard lung donor inclusion criteria. Tertiary studies included gNO plus perfusate, perfusate only, and ventilated gNO and perfusate (primary study). The XVivo perfusion device system with cell-free perfusate (Steen's solution) will be used. The maximum cold ischemia time of the lungs will be 8-10 hours. The duration of isolated lung perfusion will be up to 12 hours. Lung health was assessed by a grading system, biomarker assessment, and histopathological assessment.

[0078] Grading system

[0079] The grading system consists of a 0-10 scale (total score) using a composite measure of 3 variables. The three variables are: 1) δPaO 2 , whose weight is 0-4 when using 4 categories: 0=<350mmHg; 1=≥350-<400mmHg; 2=≥400-<450mmHg; 3=≥450-<500mmHg; 4=≥...

Embodiment 2

[0115] Example 2. Inhaled Nitric Oxide Improves Brain Mitochondrial Function in a Blinded, Randomized, Controlled Pediatric Pig Asphyxia Model of Cardiac Arrest Trials.

[0116] introduction

[0117] Nerve injury after pediatric cardiac arrest (CA) remains common. Inhaled nitric oxide (iNO) attenuates CA-induced brain mitochondrial dysfunction, a key focal point of secondary brain injury. It was hypothesized that after asphyxia and cardiac arrest, animals treated with 20 ppm iNO during CPR and within four hours after return of spontaneous circulation (ROSC) would have improved cerebral blood flow (CBF) and improved Mitochondrial function, as defined by increased respiratory control ratio and decreased mitochondrial reactive oxygen species (mtROS).

[0118] method

[0119] Four-week-old pigs were subjected to asphyxia for 7 minutes, followed by ventricular fibrillation. Instructed CPR was performed at a compression depth (CD) of ≧1 / 3 of the DBH with standard epinephrine for...

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Abstract

The present disclosure provides methods to improve the viability of an organ, or organs, by continuously administering a composition comprising NOx gas directly to the organ(s). A method to improve the viability of an organ intended for transplant, the method comprising continuously administering a composition comprising NOx gas directly to the organ via an organ perfusion system or ventilation.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application No. 62 / 550,463, filed August 25, 2017, the disclosure of which is incorporated herein by reference in its entirety. technical field [0003] The present disclosure provides for the continuous administration directly to one or more organs comprising NO x The composition of gases to enhance the viability of one or more organs. Background technique [0004] Cells, tissues, organs and organisms that have lost proper blood flow undergo ischemic damage and eventually die due to oxidative stress. Traditional methods of reducing ischemic injury involve perfusing affected tissues with oxygen, but this method can lead to significant tissue damage and can lead to severe and / or permanent damage, such as brain damage during stroke or cardiac arrest. [0005] Attempts have been made to reduce ischemia and reperfusion injury by inducing tissues and organs into a reduced...

Claims

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Application Information

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IPC IPC(8): A01N1/02
CPCA01N1/0226A01N1/0247A01N1/021A61B2017/00969A61B17/00
Inventor J·普朗西亚诺
Owner MALLINCKRODT HOSPITAL PRODUCTS IP LTD
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