Cosmetic composition for wrinkle reduction or Anti-inflammation, containing substance p

A cosmetic composition and skin-improving technology, applied in the direction of cosmetics, cosmetic preparations, skin care preparations, etc., can solve the problems of anti-wrinkle and anti-inflammatory effects, redness, application restrictions, etc., to improve skin wrinkles or inflammation Effect

Inactive Publication Date: 2020-05-19
株式会社生物解决方案有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Among them, the most widely known retinol promotes the synthesis of collagen, but it causes skin irritation, redness, etc. when used as a cosmetic material
Its application is also limited because it is unstable to light
The effect of chlorella extract is not obvious, so it is difficult to expect the effect of improving skin wrinkles
As described, the use of these substances is limited due to safety concerns such as irritation and redness when applied to the skin, or their effects are not apparent
Therefore, there is a problem that the effect of improving wrinkles cannot actually be expected
However, the reduced anti-wrinkle and anti-inflammatory effects due to its instability need to be addressed for the use of substance P in anti-wrinkle and anti-inflammatory cosmetics

Method used

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  • Cosmetic composition for wrinkle reduction or Anti-inflammation, containing substance p
  • Cosmetic composition for wrinkle reduction or Anti-inflammation, containing substance p
  • Cosmetic composition for wrinkle reduction or Anti-inflammation, containing substance p

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Example 1: Evaluation of the stability of substance P according to the content of antioxidants and surfactants

[0074] Before preparing a composition including substance P for improving skin wrinkles or inflammation, the present inventors examined the antibacterial properties suitable for cosmetic compositions by conducting an evaluation test of the stability of substance P according to the content of antioxidants and surfactants. Optimal content of oxidizing agents and surfactants.

[0075] To substance P, sodium thiosulfate was added as an antioxidant by varying its content (0.05%, 0.1%, 0.5% and 1%), by varying its content (0.003%, 0.006%, 0.01%, 0.05% and 0.1 %) Adding polysorbate 80 as a surfactant to prepare respective compositions, the stability of substance P in each of the formulations having different contents of sodium thiosulfate and polysorbate 80 was measured.

[0076] Such as figure 1 As shown in , it was demonstrated that in compositions including 0.1...

Embodiment 2

[0077] Example 2: Preparation of a composition comprising substance P for the improvement of skin wrinkles or inflammation

[0078] A novel formulation was prepared by adding to substance P sodium thiosulfate as an antioxidant, polysorbate 80 as a surfactant, and hydroxyethylcellulose as a thickener. Substance P was synthesized by Fmoc-chemistry (which is a peptide synthesis technique) by solid / liquid phase and purified by high performance liquid chromatography. Finally, substance P with a purity of 85% or greater is used.

[0079] Table 1

[0080]

Embodiment 3

[0081] Example 3: Investigation of the stability of compositions comprising substance P in culture medium of skin fibroblasts

[0082] The stability of compositions comprising substance P was investigated in dermal fibroblast culture medium. Compositions comprising Substance P (5 μg / ml) prepared according to Table 1 or Substance P (5 μg / ml) dissolved in phosphate buffered saline (PBS) as a comparative example were applied to skin fibroblast culture medium ( FGM, Lonza, USA) for 0 hours, 3 hours, 6 hours, 12 hours and 24 hours, and then measure the content of substance P remaining in the medium over time. The content of substance P was quantified by ELISA using the substance P ELISA kit (Abcam, USA). At this time, the sample applied for 0 hours was used as a control group. The control group was regarded as 100%, and the content of substance P remaining in the medium over time was calculated as a percentage (%).

[0083] As a result, in the group treated with substance P diss...

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PUM

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Abstract

The present invention relates to a composition for reducing skin wrinkles or inflammation, containing a substance P (SP)-containing composition as an active ingredient and, more specifically, to: a novel use of a composition containing SP for reducing skin wrinkles or inflammation by promoting collagen synthesis, inhibiting collagenase generation, and performing an anti-inflammatory reaction; anda cosmetic composition for reducing skin wrinkles and inflammation, containing the composition. The SP-containing composition of the present invention exhibited an improved skin wrinkle or inflammation reduction effect over that of SP by means of the synergistic action achieved by an antioxidant, a surfactant, and a thickening agent which are added for stabilizing SP with respect to the basic characteristics of SP, which is conventionally known to be effective for reducing skin wrinkles or inflammation. Therefore, the composition of the present invention can be useful as a cosmetic compositionfor reducing skin wrinkles or inflammation.

Description

technical field [0001] The present invention relates to a cosmetic composition for improving wrinkling or inflammation of the skin, the cosmetic composition comprising substance P as an active ingredient. More particularly, the present invention relates to a cosmetic composition having an anti-wrinkle or anti-inflammatory effect by promoting collagen synthesis, inhibiting collagenase (MMP-1) synthesis, and performing an anti-inflammatory response. Background technique [0002] The cosmetics industry tends to grow steadily. Among various cosmetic-related industries, skin aging-related cosmetic products are considered to be a rapidly growing segment. Skin aging is caused by various factors. Factors directly affecting skin aging can be broadly classified into wrinkle formation due to decrease in collagen in the skin and inflammatory response due to oxidative stress. [0003] Collagen is a major component of the extracellular matrix, which is the major matrix protein produced...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/23A61Q19/08
CPCA61K8/23A61K8/64A61Q19/08A61K8/731A61K8/604A61K2800/48
Inventor 金茶晶李定宣张松善
Owner 株式会社生物解决方案有限公司
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