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Nauclea officinalis-mulberry eye drops, and preparation method and application thereof

A technology of eye drops and mulberry leaves, applied in medicines, in the field of dan mulberry eye drops and preparation thereof, can solve the problems of inability to eradicate the cause of disease, unsatisfactory drug effectiveness, etc., and achieve rapid relief of dry eye symptoms , Reduce dry eyes, relieve dry eye symptoms

Inactive Publication Date: 2020-05-22
HAINAN SENQI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a variety of drugs are clinically available for the treatment of dry eye, the effectiveness of most drugs is not satisfactory. For example, artificial tears, the most commonly used in the treatment of dry eye, need repeated administration, but can only relieve dry eye symptoms , but cannot eradicate its cause

Method used

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  • Nauclea officinalis-mulberry eye drops, and preparation method and application thereof
  • Nauclea officinalis-mulberry eye drops, and preparation method and application thereof
  • Nauclea officinalis-mulberry eye drops, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, Dansang eye drops

[0031] Prescription: 5g of decocting liquid of gall leaves, 5g of decocting liquid of mulberry leaves, 5g of sodium hyaluronate, appropriate amount of sodium chloride (adjust the osmotic pressure to 290-310mOsmol / kg), appropriate amount of borate buffer solution (adjust the pH value to 6-7.5), supplemented with water for injection to 100g.

[0032] Preparation:

[0033] a. Weigh the decoction of gallwood leaves, decoction of mulberry leaves, and sodium hyaluronate, add 3 / 5–4 / 5 of the total amount of water for injection, stir to dissolve, and then adjust the osmotic pressure to 290-310mOsmol / kg, use The pH value regulator adjusts the pH value to 6-7.5, and then adjusts the volume to the total amount of water to obtain the liquid medicine;

[0034] b. In a grade A environment, filter the liquid medicine obtained in step a through 0.45 μm and 0.22 μm microporous membranes, fill it, and sterilize it.

Embodiment 2-5、 comparative example 6-7

[0036] prescription:

[0037] product name Example 2 Example 3 Example 4 Example 5 Comparative example 6 Comparative example 7 gallbladder leaf decoction 6g 7g 8g 9g 9g - Mulberry leaf decoction 6g 7g 8g 9g - 9g sodium hyaluronate 5g 5g 5g 5g 5g 5g Sodium chloride Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount borate buffer Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Water for Injection Add to 100g Add to 100g Add to 100g Add to 100g Add to 100g Add to 100g

[0038] Note: The appropriate amount in the table is the amount needed to adjust the osmotic pressure and pH, "-" means not added.

[0039] The preparation method is the same as Example 1.

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and discloses nauclea officinalis-mulberry eye drops, and a preparation method and application thereof. According to the invention, every 100 parts by weight of the nauclea officinalis-mulberry eye drops comprise 5-9 parts by weight of a nauclea officinalis leaf decoction, 5-9 parts by weight of a mulberry leaf decoction, 3-6 parts by weight of sodium hyaluronate and the balance of water for injection. According to the nauclea officinalis-mulberry eye drops, the nauclea officinalis leaf decoction and the mulberryleaf decoction are taken as main medicines, so that the nauclea officinalis-mulberry eye drops are safe and non-irritant, have good drug resistance, and can quickly relieve dry eye symptoms and have an obvious curative effect after directly acting on affected parts. The nauclea officinalis-mulberry eye drops are safe and non-toxic, have stable performance, can obviously increase the secretion amount of tears, prolong the rupture time of tear films, reduce the risks of dryness and infection of eyes and the like, and can be used as a medicine for treating dry eye symptoms. The preparation methodof the nauclea officinalis-mulberry eye drops has simple process, low cost, environmental friendliness and short production period, is suitable for mass industrial production, and has a great application prospect and remarkable economic benefit.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a dansang eye drop and its preparation method and application, especially the application in the preparation of medicine for treating dry eye. Background technique [0002] Dry eye syndrome (DES) is a common eye disease, also known as keratoconjunctivitis sicca. Itching, foreign body sensation, burning sensation, or photophobia, blurred vision, and vision fluctuations. Common symptoms include dry eyes, easy fatigue, itchy eyes, foreign body sensation, burning sensation, sticky secretions, fear of wind, photophobia, and sensitivity to external stimuli; sometimes the eyes are too dry, and there is basically insufficient tear fluid, which stimulates the reflex In severe cases, the eyes will be red and swollen, congested, keratinized, and the corneal epithelium is broken and there are filaments adhered. This kind of damage can cause keratoconjunct...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K9/08A61K47/02A61P27/02A61K31/728
CPCA61K9/0048A61K9/08A61K31/728A61K36/605A61K36/74A61K47/02A61P27/02A61K2300/00
Inventor 李锦云韩法河张鹏柯泽涛谢晨星
Owner HAINAN SENQI PHARMA CO LTD
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