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Eye drops and preparation method thereof

A technology of eye drops and chitosan derivatives, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of affecting the balance of eye flora and aggravating eye health Effects, eye drop dependence and other problems, to achieve the effect of assisting in maintaining ocular surface health, promoting wound healing, and relieving pain

Active Publication Date: 2022-08-05
青岛博益特生物材料股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, for people who have undergone myopia surgery, eye fatigue and eye dryness are more serious than ordinary people when they look at computers or mobile phones. At present, most eye drops on the market have a short action time and can only temporarily relax the eyes. People who have undergone myopia surgery sometimes even need to drop eye drops once in half an hour or an hour. Frequent instillation of eye drops containing antibiotics or bacteriostatic agents can easily cause people to be overly sensitive to eye drops. Dependence, and the more times you add eye drops, the easier it is to affect the balance of eye flora, which will aggravate the impact on eye health

Method used

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  • Eye drops and preparation method thereof
  • Eye drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: An eye drop:

[0042] Chitosan derivative 0.25kg, hydroxypropyl methylcellulose 0.25kg, sodium hyaluronate 0.3kg, osmotic pressure regulator 0.9kg, chelating agent 0.25kg, bacteriostatic agent 0.008kg, sodium perborate tetrahydrate 0.005 kg, propylene glycol 0.5kg, boric acid 3kg, water 95kg; chitosan derivative is carboxymethyl chitosan; osmotic pressure regulator is composed of NaCl and KCl with a weight ratio of 1:2; bacteriostatic agent is composed of a weight ratio of 1 : 1 phenoxyethanol and ethyl hydroxyphenyl are formed; the chelating agent is EDTA-2Na;

[0043] The preparation method is as follows:

[0044] S1, weigh sodium perborate tetrahydrate, boric acid and mix and stir to obtain a premix;

[0045] S2. Weigh water and heat it to 85°C, then add hydroxypropyl methylcellulose and stir to dissolve, and then let stand at 35°C to obtain a primary mixture;

[0046] S3. Weigh the chitosan derivative and add it to the initial mixture and stir it evenl...

Embodiment 2

[0048] Embodiment 2: The difference between this embodiment and Embodiment 1 is:

[0049] Chitosan derivative 0.01kg, hydroxypropyl methylcellulose 0.01kg, sodium hyaluronate 0.01kg, osmotic pressure regulator 0.5kg, chelating agent 0.01kg, bacteriostatic agent 0.005kg, sodium perborate tetrahydrate 0.002 kg, propylene glycol 0.1kg, boric acid 0.1kg, water 85kg; the chitosan derivative is hydroxyethyl chitosan; the osmotic pressure regulator is composed of NaCl and KCl with a weight ratio of 1:1; the bacteriostatic agent is composed of a weight ratio of 1:0.6 composition of phenoxyethanol and ethyl hydroxyphenyl; chelating agent is EDTA-2Na;

[0050] During preparation:

[0051] S2. Weigh the water and heat it to 80°C, then add hydroxypropyl methylcellulose and stir to dissolve, and then let stand to 30°C to obtain the initial mixture;

Embodiment 3

[0052] Embodiment 3: The difference between this embodiment and Embodiment 1 is:

[0053] Chitosan derivative 0.5kg, hydroxypropyl methylcellulose 0.5kg, sodium hyaluronate 0.5kg, osmotic pressure regulator 1.5kg, chelating agent 0.5kg, bacteriostatic agent 0.01kg, sodium perborate tetrahydrate 0.01 kg, propylene glycol 2kg, boric acid 5kg, water 100kg; the chitosan derivative is succinyl chitosan; the osmotic pressure regulator is composed of NaCl and KCl with a weight ratio of 1:3; the bacteriostatic agent is composed of a weight ratio of 1:1.5 The composition of phenoxyethanol and ethyl paraben; the chelating agent is EDTA-2Na.

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Abstract

The invention relates to the field of preparation of medical supplies, and particularly discloses eye drops and a preparation method thereof. The eye drops are prepared from the following raw materials in parts by weight: a chitosan derivative, hydroxypropyl methyl cellulose, sodium hyaluronate, an osmotic pressure regulator, a chelating agent, a bacteriostatic agent, sodium perborate tetrahydrate, propylene glycol, boric acid and water. The preparation method comprises the following steps: mixing sodium perborate tetrahydrate and boric acid to obtain a premix; the preparation method comprises the following steps: heating water to 80-95 DEG C, then adding hydroxypropyl methyl cellulose, stirring and dissolving, and then standing to 30-40 DEG C to prepare a primary mixture; weighing a chitosan derivative, adding the chitosan derivative into the primary mixture, uniformly stirring, then adding the premix, and uniformly mixing and stirring to obtain a mixture; and weighing sodium hyaluronate and propylene glycol, adding the sodium hyaluronate and propylene glycol into the mixture, uniformly stirring, finally adding the osmotic pressure regulator, the chelating agent and the bacteriostatic agent, and continuously uniformly stirring to obtain a finished product. The eye drops have the effects of keeping eyes moist for a long time and relieving dry eye symptoms for a long time.

Description

technical field [0001] The present application relates to the field of medical device preparation, and more particularly, to an eye drop and a preparation method thereof. Background technique [0002] With the change of people's life style and work style, more and more time is spent with eyes, such as long-term viewing of computers, watching TV, playing mobile phones, playing video games, etc., which can easily lead to eye fatigue and dry eyes; Eye drops have gradually attracted people's attention. Eye drops have the effect of relieving eye fatigue and dry eyes. [0003] However, for people who have undergone myopia surgery, their eye fatigue and dry eyes are more serious than ordinary people when they look at computers or mobile phones every day. At present, most eye drops on the market have a short action time and can only relax the eyes for a short time. It has poor persistence, and people who have had myopia surgery sometimes even need to drop eye drops every half an ho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/22A61K33/14A61K31/722A61K31/717A61K31/728A61K31/047A61K31/235A61K31/085A61K47/42A61K47/24A61K9/08A61P27/02
CPCA61K33/22A61K33/14A61K31/722A61K31/717A61K31/728A61K31/047A61K31/235A61K31/085A61K47/42A61K47/24A61K9/08A61K9/0048A61P27/02A61K2300/00Y02A50/30
Inventor 姜惠萍孙雪燕李怀生石杰冯伊琳
Owner 青岛博益特生物材料股份有限公司
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