Method for preparing 4- (2 '-indolyl)-1, 3-eneyne derivative

Abstract

The invention relates to a method for preparing a 4- (2 '-indolyl)-1, 3-enyne derivative. Specifically, 4-ethynyl-1, 4-dihydro-2H-benzo [d] [1, 3]-oxahexane-2-one is used as a raw material under the action of an alkali, and the 4- (2 '-indolyl)-1, 3-enyne derivative is constructed in one step through a two-molecule reaction catalyzed by a transition metal. The method has the advantages of cheap and easily available reagent, simple operation, wide substrate application range and the like.

Description

technical field [0001] The present invention relates to a method for preparing 4-(2'-indolyl)-1,3-enyne derivatives. Background technique [0002] In recent years, 4-ethynyl-1,4-dihydro-2H-benzo[d][1,3]-nitroxane-2-one compounds are often used in organic synthesis in copper-catalyzed systems , is an efficient synthon. However, the substrate has many reaction sites, and it is easy to undergo intramolecular cyclization or intermolecular cyclization under acid-base or metal catalysis, so it is difficult to control the regioselectivity of the reaction. This reaction provides a method for the selective synthesis of unsymmetrical enynes. Contents of the invention [0003] The object of the present invention is to provide a method for synthesizing 4-(2'-indolyl)-1,3-enynes. [0004] [0005] The specific operation steps are as follows: [0006] React in the reactor, add 4-ethynyl-1,4-dihydro-2H-benzo[d][1,3]-nitroxane-2-one (1), then add catalyst, compound Body, base and ...

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Problems solved by technology

However, the substrate has many reaction sites, and it is easy to undergo intramolecular or intermolecular cycl

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