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Application of ACTA2 methylation as asthma diagnosis marker

A methylation and asthma technology, applied in the field of ACTA2 methylation as a diagnostic marker for asthma, can solve problems such as inability to easily and accurately diagnose early asthma.

Active Publication Date: 2020-06-23
AFFILIATED HOSPITAL OF JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to provide a methylation site as an early diagnosis marker for asthma, so as to solve the technical problem that the markers in the prior art cannot diagnose early asthma conveniently and accurately

Method used

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  • Application of ACTA2 methylation as asthma diagnosis marker
  • Application of ACTA2 methylation as asthma diagnosis marker
  • Application of ACTA2 methylation as asthma diagnosis marker

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Asthma related methylation research

[0033] 1. Research object

[0034] The research cohort (cohort A) selected 6 adult patients with asthma who visited the Respiratory Clinic of the Affiliated Hospital of Jiangsu University from October 2017 to October 2018. The control group selected 5 cases of the same period, the same place of residence, similar age, similar sex ratio, and similar to asthma The general information of the patients who had no direct blood relationship and healthy physical examination is shown in Table 1. The verification cohort (cohort B) selected 12 adult patients with asthma who visited the Respiratory Clinic of the Affiliated Hospital of Jiangsu University from October 2018 to October 2019. The control group selected 12 cases of the same period, the same place of residence, similar age, similar sex ratio, and similar to asthma The general information of the patients without direct blood relationship is shown in Table 2. The study was app...

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Abstract

The invention discloses application of ACTA2 methylation as an asthma diagnosis marker. ACTA2 methylation loci disclosed by the invention are selected from one or more of cg19791409, cg17967429, cg09822170 and cg17133119. Compared with health comparison, a patient suffering from asthma has a remarkably increased methylation levels at the methylation loci, and the methylation loci can be used as molecular markers for diagnosing asthma according to correlation of variation of methylation of the methylation loci with asthma. The invention further discloses a kit for diagnosing asthma. The kit hasgood clinical application prospects.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the use of ACTA2 methylation as a diagnostic marker for asthma. Background technique [0002] Asthma is a common chronic respiratory disease characterized by complex respiratory symptoms and reversible airflow limitation. Asthma has a high incidence worldwide, but due to the large differences in its phenotype and pathogenesis [Mccracken J L, Veeranki S P, Ameredes B T, et al. Diagnosis and Management of Asthma in Adults: A Review [J]. JAMA, 2017,318(3):279-290], which brings certain difficulties to diagnosis and treatment, and the consequences of lost work and study caused by this have caused relatively large economic losses. Therefore, looking for more reliable and intuitive diagnostic indicators has become a hot spot in asthma research. At present, it is widely believed that asthma is a disease affected by both environment and genetics [Yang I V, Lozupone C A, Schwartz D A. The e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/136C12Q2600/154
Inventor 钱粉红张黎莎
Owner AFFILIATED HOSPITAL OF JIANGSU UNIV
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