Normal-temperature mechanical organ perfusate and application thereof

Abstract

The invention relates to a normal-temperature mechanical organ perfusate and an application thereof, and concretely provides an application of an isolated organ perfusate in the preparation of a medicine for preserving an isolated organ for transplantation. Per 1000 mL of the isolated organ perfusate comprises 10 g of macromolecular polymerized hemoglobin, 2.5-4 g of glucose, 7500-10000 u of heparin sodium, 2-3 g of sodium chloride, 0.5-0.75 g of cefoxitin sodium, 0.37-0.5 g of sodium bicarbonate, 15-20 mL of a 10% compound amino acid injection, 0.05-0.08 mL of 12-vitamin compound for injection, 50-80 u of insulin, and the balance of water. The perfusate can play a role in carrying and releasing oxygen for a long time, so that the perfusion preservation time of isolated organs is remarkably prolonged.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a normal-temperature mechanical organ perfusate and its application. Background technique [0002] Many human diseases come from the necrosis of cells, tissues, and organs, resulting in loss of function, disability, and even death. With the development of modern medicine, organ transplantation technology is becoming more and more mature. From the perspective of surgery: organ transplantation technology is perfect , head replacement surgery is not a big problem. In fact, organ transplantation still faces various difficulties, and the preservation of isolated organs is one of them. Organ transplantation requires the transplantation of living organs. Therefore, from the time when the organ for transplantation is cut off from the donor to the time when its main blood vessels are connected to the recipient's blood vessels, it always maintains a complete anatomical structure and activit...

AI Technical Summary

Problems solved by technology

In the company's previous patent (201910846580.9), highly active oxygen-carrying hemoglobin was obtained through glutaraldehyde polymerization, and added to the organ perfusion fluid to meet the oxygen required by the normal temperature metabolism of the organ, which solved the problem of organ hypoxia. The problem of long-term storage at room temperature has increased the storage time of organs at room temperature, but sometimes it cannot meet the actual clinical storage time needs. If the time is inconsistent, the organ may not be used for transplantation due to inactivation. This time limit has become a major cause of the donor organ shortage crisis, making it difficult for many patients to wait for transplantation

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