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Compositions, devices, and methods for organ sustained maintenance

A technology of isolated organs and containers, applied in the field of medical devices, to achieve the effect of prolonging the storage time

Active Publication Date: 2020-07-14
REDPHARM BEIJING BIOPHARMACEUTICAL INST CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, there is an unmet need for safe hemoglobin-based compositions and systems, devices and methods used in conjunction therewith, e.g. for human therapy, organ sustainability or storage

Method used

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  • Compositions, devices, and methods for organ sustained maintenance
  • Compositions, devices, and methods for organ sustained maintenance
  • Compositions, devices, and methods for organ sustained maintenance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[1016] figure 1 It is a schematic structural diagram of the organ mechanical perfusion device in Example 1. In this embodiment, the organ mechanical perfusion device includes a container 1 , a pumping unit 2 , an oxygenator 3 and an ultrafiltration unit 4 . A holder 11 is arranged inside the container 1 , and a cover 12 is arranged on the top of the container 1 . The pumping unit 2 and the oxygenator 3 are arranged in series in the pipeline between the outlet and the inlet of the container 1, wherein the pumping unit 2 is used to drive the perfusate in the whole device to flow to form a continuous perfusion flow, oxygenation The device 3 is used for extracorporeal oxygenation and carbon dioxide discharge of the flowing perfusate, increasing the oxygen content of hemoglobin in the perfusate flowing back into the container 1 and the ultrafiltration effect on the loose R-state hemoglobin. The ultrafiltration unit 4 is connected with the perfusate bag in the pumping unit 2 and ...

Embodiment 2

[1027] figure 2 It is a schematic structural diagram of the organ mechanical perfusion device in Example 2. The difference between the organ mechanical perfusion device in this embodiment and the organ mechanical perfusion device in Embodiment 1 is that there is also a perfusion organ return pipe 13 between the outlet of the container 1 and the inlet of the pumping unit 2, and the outlet of the pumping unit 2 A perfusion organ liquid inlet pipe 21 is also provided between the inlet of the container 1, thereby forming a double-pipeline perfusion structure for the organ. In this way, for the perfusion operation of some organs, such as the perfusion operation of the liver, the double-line perfusion with portal vein and aorta can be realized, thereby improving the perfusion application of the device to different organs, expanding the scope of use of the device, and improving its use. efficiency.

Embodiment 3

[1029] image 3 It is a schematic structural diagram of the organ mechanical perfusion device in Example 3. The difference between the organ mechanical perfusion device in this embodiment and the organ mechanical perfusion device in Embodiment 1 is that two sets of independent pumping units 2, oxygenators 3 and ultrafiltration units 4 are provided to form a double set of containers 1. Parallel perfusate circulation. In this way, a double perfusate circulation for the organs in the container can be formed, which can not only improve the efficiency and stability of the perfusion treatment of the organs, but also realize the setting of a separate circulation system such as pressure and flow to meet more complex requirements. Perfusion needs. Similarly, in other embodiments, the number of pumping units, oxygenators, and ultrafiltration units can also be adjusted according to the perfusion and preservation conditions of the organ, so as to meet the requirements of perfusion and p...

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Abstract

The invention relates to the field of medical instruments, in particular to compositions, a device and method for organ sustained maintenance. The invention provides an isolated organ perfusate, a method for preserving an isolated organ and an isolated organ perfusion device. According to the isolated organ perfusate and the method for storing the isolated organ by using the isolated organ perfusate and the isolated organ perfusion device, the oxygen carrying and releasing functions can be played for a longer time, so that the perfusion storage time of the isolated organ is remarkably prolonged.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to components, devices and methods for organ continuous maintenance. Background technique [0002] In humans and mammals, hemoglobin is the iron-containing oxygen-transport metalloprotein in red blood cells that transports oxygen from the lungs to the rest of the body (i.e., tissues). There, it releases oxygen that enables aerobic respiration to provide the energy that powers the organism's functions during metabolism. Healthy people contain 12 to 20 grams of hemoglobin per 100 milliliters of blood. The oxygen binding capacity of hemoglobin is 1.34 milliliters of oxygen per gram, compared with the dissolved oxygen in the blood, the total blood oxygen capacity has increased by 70 times. Mammalian hemoglobin molecules can bind four oxygen molecules. In most vertebrates, the hemoglobin molecule is composed of four globular protein subunits. Each subunit consists of a protein chain ti...

Claims

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Application Information

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IPC IPC(8): A01N1/02
CPCA01N1/0247
Inventor 游可为史国营陈浩源
Owner REDPHARM BEIJING BIOPHARMACEUTICAL INST CO LTD
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