Blood perfusion resin as well as preparation method and application thereof

A technology of blood perfusion and resin, applied in the field of medical polymer

Active Publication Date: 2021-09-10
SUNRESIN NEW METERIALS CO LTD XIAN +1
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Therefore, in order to solve the disadvantage that the hemoperfusion resin used for scavenging bilirubin in the prior art cannot have both good bilirubin scavenging performance and biocompatibility, the present invention provides a hemoperfusion resin and its preparation method and application , the hemoperfusion resin includes polydivinylbenzene and polyvinylpyrrolidone, the crosslinking degree of the hemoperfusion resin is ≥80%, and the weight percentage of polyvinylpyrrolidone in the hemoperfusion resin is not less than 16%, Both good bilirubin scavenging performance and excellent anti-nonspecific protein adsorption performance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Blood perfusion resin as well as preparation method and application thereof
  • Blood perfusion resin as well as preparation method and application thereof
  • Blood perfusion resin as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] This embodiment provides a hemoperfusion resin, the preparation method of which is as follows:

[0063] Add the water phase (96g of PVA aqueous solution of 10% by weight, 864g of distilled water) in a 2000ml three-necked flask, stir evenly, and heat up to 40°C. After the water phase is mixed evenly, add the oil phase prepared in advance (80g of DVB80 after deblocking, 240g of toluene, 0.8g of BPO), stir, and heat up at a speed of 5°C / 10min, first to 78°C, and keep warm for 2h; Raise the temperature to 83°C and keep it warm for 3h; finally raise the temperature to 88°C and keep it warm for 3h. After the polymerization is completed, the reaction system is cooled, the resin is packed into a column, the PVA is washed away with hot water, and then the toluene is washed away with ethanol. Put the resin into an oven and dry it at 65°C to obtain the base ball.

[0064] Add 20 g of the above-mentioned base balls into a 1000 ml three-necked flask, mix 64 g of toluene, 16 g of D...

Embodiment 2

[0066] This embodiment provides a hemoperfusion resin, the preparation method of which is as follows:

[0067] Add the water phase (96g of PVA aqueous solution of 10% by weight, 864g of distilled water) in a 2000ml three-necked flask, stir evenly, and heat up to 40°C. After the water phase is mixed evenly, add the oil phase prepared in advance (80g of DVB80 after deblocking, 240g of toluene, 0.8g of BPO), stir, and heat up at a speed of 5°C / 10min, first to 78°C, and keep warm for 2h; Raise the temperature to 83°C and keep it warm for 3h; finally raise the temperature to 88°C and keep it warm for 3h. After the polymerization is completed, the reaction system is cooled, the resin is packed into a column, the PVA is washed away with hot water, and then the toluene is washed away with ethanol. Put the resin into an oven and dry it at 65°C to obtain the base ball.

[0068] Add 20 g of the above-mentioned base balls into a 1000 ml three-necked flask, mix 64 g of toluene, 16 g of D...

Embodiment 3

[0070] This embodiment provides a hemoperfusion resin, the preparation method of which is as follows:

[0071] In a 2000ml there-necked flask, add the water phase (72g of an aqueous solution of 10% by weight of PVA, 648g of distilled water), stir evenly, and heat up to 40°C. After the water phase is mixed evenly, add the oil phase prepared by mixing in advance (DVB80 after deblocking 80g, toluene 240g, BPO 0.8g), adjust the stirring speed, stir, and heat up at a speed of 5°C / 10min, first to 78°C, Keep it warm for 2 hours; then raise the temperature to 83°C and keep it warm for 3 hours; finally raise the temperature to 88°C and keep it warm for 3 hours. After the polymerization is completed, the reaction system is cooled, the resin is packed into a column, the PVA is washed away with hot water, and then the toluene is washed away with ethanol. Put the resin into an oven and dry it at 65°C to obtain the base ball.

[0072] Add 20 g of the above-mentioned base balls into a 1000...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
specific surface areaaaaaaaaaaa
adsorption capacityaaaaaaaaaa
Login to view more

Abstract

The invention relates to the field of medical polymers, and particularly provides blood perfusion resin and a preparation method and application thereof.The blood perfusion resin comprises polydivinylbenzene and polyvinylpyrrolidone, the crosslinking degree of the blood perfusion resin is larger than or equal to 80%, and the weight percentage content of polyvinylpyrrolidone in the blood perfusion resin is not lower than 16%. Researches find that when the cross-linking degree of blood perfusion resin formed by polydivinylbenzene and polyvinylpyrrolidone is controlled to be larger than or equal to 80% and the weight percentage content of polyvinylpyrrolidone is kept to be not lower than 16%, the blood perfusion resin is high in bilirubin adsorption capacity and does not adsorb other components such as albumin in serum, or the adsorption capacity is low, and the bilirubin removal performance and the excellent non-specific protein adsorption resistance can be achieved at the same time.

Description

technical field [0001] The invention relates to the field of medical polymers, in particular to a hemoperfusion resin and its preparation method and application. Background technique [0002] Bilirubin is the metabolite of hemoglobin in aging red blood cells in the human body. It can play an effective antioxidant role in the human body at physiological concentrations. However, when excessive bilirubin is produced, or the uptake, transformation or When the excretion process is blocked, the bilirubin concentration in the blood will accumulate to a higher value, resulting in hyperbilirubinemia, which will cause a series of damage to tissues and organs. The treatment of hyperbilirubinemia currently lacks specific and effective drugs. Conventional medical treatment of hyperbilirubinemia takes a long time and is ineffective, and has a high mortality rate. The clinical mortality rate of patients with liver failure is as high as 60-80%. Hemoperfusion technology is a blood purificat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C08F112/36C08F2/20C08J9/28C08J9/40B01J20/26B01J20/30A61M1/36C08L25/02
CPCC08F112/36C08J9/28C08J9/405B01J20/261A61M1/36C08J2325/02C08J2207/10B01J2220/4812C08F2/20
Inventor 寇佐今王春红刘琼李延军刘龙侯亮来
Owner SUNRESIN NEW METERIALS CO LTD XIAN
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap