Compound vegetable oil vaccine adjuvant and its application

Abstract

The invention discloses a compound vegetable oil vaccine adjuvant, which is prepared according to the following method: 1), the compound vegetable oil adjuvant is composed of the following components in volume content: 1.50%-3.5% oleic acid, 9.5%-12.5% ​​Span- 85. 2.50%-3.50% polyglycerol ricinoleate, and the balance is vegetable oil; 2), according to the dosage ratio of 2-8mg ginsenoside / 100ml compound vegetable oil adjuvant, add ginsenoside solution to the compound vegetable oil adjuvant, A compound vegetable oil vaccine adjuvant was obtained. The vaccine prepared with the adjuvant of the present invention is easily absorbed by the body after being injected into animals, is not easy to form vaccine residues at the injection site, can prolong the duration of antibodies, and can better protect immunized animals.

Description

technical field [0001] The invention relates to the technical field of vaccine adjuvants, in particular to a ginsenoside-containing vegetable oil vaccine adjuvant and its preparation method and application. Background technique [0002] The livestock and poultry breeding industry provides an important protein source for human beings and is an indispensable and important industry for human beings. In large-scale farms, due to the high density of animals, the frequent contact between animals makes it easier for diseases to spread among animals. Injecting animals with vaccines can cause animals to produce specific immune responses, improve animal resistance to epidemic diseases, reduce the occurrence of epidemic diseases, and reduce the economic losses caused by epidemic diseases to farmers. It is an important measure to prevent animal epidemics. In order to improve the immune effect of the vaccine, it is necessary to add an adjuvant to the vaccine to enhance the intensity of ...

AI Technical Summary

Problems solved by technology

[0005] 1. The residual polycyclic aromatic hydrocarbons in mineral oil adjuvants have carcinogenic effects, and the adjuvants can pose a potential threat to food safety after being made into vaccines to immunize animals;

[0006] 2. Traditional mineral oil adjuvants are not easily absorbed and metabolized in animals, which affects the quality of animal products;

[0007] 3. The flash point of traditional mineral oil adjuvants is relatively low, easy to burn, and unsafe to store

[0023] The vegetable oil adjuvant obtained by the above two patents prepares the vaccine, which is an oil-in-water (O / W) emulsion, and the adjuvant effect is weak

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