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Medical application of compound in treatment of oral cancer by inducing apoptosis of oral cancer cells

A technology for oral cancer and uses, applied in the field of medicine, can solve problems such as chalcone derivatives that have not yet been seen

Inactive Publication Date: 2020-07-07
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] There is no report that chalcone derivatives with the following chemical structure are used to prepare anti-oral cancer drugs

Method used

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  • Medical application of compound in treatment of oral cancer by inducing apoptosis of oral cancer cells
  • Medical application of compound in treatment of oral cancer by inducing apoptosis of oral cancer cells
  • Medical application of compound in treatment of oral cancer by inducing apoptosis of oral cancer cells

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Embodiment Construction

[0024] The following describes the substantive content of the present invention in detail in conjunction with the drawings and embodiments, but does not limit the protection scope of the present invention.

[0025] 1. Experimental materials

[0026] Human oral cancer KB cells were cryopreserved in liquid nitrogen and used after recovery according to conventional methods.

[0027] The brands of fetal bovine serum, RPMI1640 medium, and trypsin are Gibco.

[0028] The brands of penicillin and streptomycin are Sigma, and the PBS solution is made according to the formula. The purity of chalcone derivative 1 and chalcone derivative 2 is ≥98%, and the chemical structure is as follows figure 1 shown.

[0029] Cell culture plates were purchased from Thermo Scientific.

[0030] Transwell chamber (24 wells) was purchased from Corning Company.

[0031] CCK-8 kit was purchased from Japanese colleagues.

[0032] The brand of AnnexinV-FITC / PI Apoptosis Detection Kit is Solarbio.

[00...

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Abstract

The invention discloses medical application of a compound in treatment of oral cancer by inducing apoptosis of oral cancer cells. Two chalcone derivatives are found to inhibit growth of the oral cancer by inhibiting proliferation of the oral cancer cells and inducing apoptosis of the oral cancer cells on one hand, and inhibit migration activity of the oral cancer cells on the other hand. Therefore, the two chalcone derivatives have the prospect of being developed into drugs for resisting growth of the oral cancer and resisting metastasis of the oral cancer and are used for treating the oral cancer.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the screening and discovery of oral cancer drugs, in particular to the medical use of a compound for treating oral cancer by inducing the apoptosis of oral cancer cells. Background technique [0002] Oral cancer is a common head and neck tumor with a high incidence. In recent years, with the rapid development of the global economy and the improvement of people's living standards, the incidence of oral cancer has increased significantly, and the incidence of oral cancer tends to be younger. [0003] Surgical treatment is currently the most effective clinical treatment. However, due to the relatively insidious onset of oral cancer, it is often discovered at an advanced stage and the best time for surgical treatment is missed. In addition, chemotherapy is also an important treatment method for oral cancer. The treatment drugs include fluorouracil and cisplatin. However, the existing chemothera...

Claims

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Application Information

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IPC IPC(8): A61K31/495A61P35/00A61P35/04
CPCA61K31/495A61P35/00A61P35/04
Inventor 孙强郑宏雨李紫璇陈怡恒赵军方薛文华李光辉孙明磊
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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