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A Spatial Structure Model of Modularly Assembled Peptide Chains

A spatial structure and modular technology, applied in the field of teaching and scientific research equipment, can solve the problems of students who are difficult to intuitively understand, difficult to display, and simulate the spatial structure of proteins, so as to facilitate teaching and scientific research, deepen understanding and mastery, and be easy to operate Effect

Active Publication Date: 2021-12-14
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] When teachers describe the secondary structure of proteins, they only rely on textbook graphics and simple two-dimensional graphics to help students understand and master, so it is difficult for students to understand intuitively
In the existing teaching and scientific research of protein structure and function, there is no basic model that can simply and intuitively display the spatial structure of peptide chains
The existing patented technology: a modular assembly protein structure model (CN201510262260.0) device is difficult to actually display and simulate the real protein spatial structure

Method used

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  • A Spatial Structure Model of Modularly Assembled Peptide Chains
  • A Spatial Structure Model of Modularly Assembled Peptide Chains
  • A Spatial Structure Model of Modularly Assembled Peptide Chains

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Embodiment 1 Determination of the basic size data of the first basic module

[0074] According to the position of the six atoms of the peptide plane and the basic theoretical data of the corresponding bond angle and bond length, the module size and data parameters of the peptide plane teaching aid model are made, so as to determine the size of the first basic module, the bond angle remains unchanged, and the bond length can be equal. scaling.

[0075] figure 1 It is the basic theoretical data diagram of the positions of the six atoms on the peptide plane and the corresponding bond angles and bond lengths, where the distance between the C atom and the N atom is 0.132nm, the distance between the C atom and the O atom is 0.123nm, and the distance between the N atom and the The distance between the H atom is 0.101nm, the distance between the C atom and the Cα atom in the lower left corner is 0.153nm, the distance between the N atom and the Cα atom in the upper right corne...

Embodiment 2

[0077] Example 2 Using the third basic module, the fourth basic module and the fifth basic module to assemble and display peptide bonds, amino acid residues and oligopeptides such as dipeptides and tripeptides

[0078] The peptide bond is formed by the dehydration condensation of the α-amino group of one amino acid and the α-carboxyl group of another amino acid, so the third basic module (carbonyl terminal module) and the fourth basic module (imino terminal module) are used to display and Assembled, such as Figure 21 shown. The peptide chain amino acids exist in the form of residues, so the fourth basic module (imino terminal module), the fifth basic module (Cα module), and the third basic module (carbonyl terminal module) can be used in order from left to right assembled into amino acid residues, such as Figure 22 shown. The basic assembly method of oligopeptide: the fourth basic module - the fifth basic module - the third basic module - the fourth basic module - the fif...

Embodiment 3

[0079] Example 3 Using the third basic module, the seventh special module, the second special module and the third special module to assemble and display the peptide bond formed by the amino terminal of proline

[0080] Proline is an imino acid, and its residue model consists of a proline-specific peptide planar module, a proline α carbon structure module, and three proline side chain carbon structure modules. The proline-specific detachable module of the present invention can assemble and display the peptide bond structure formed by the amino terminal of proline, wherein proline can also form two kinds of trans linkage and cis linkage, respectively as Figure 23 and Figure 24 shown.

[0081] Prepare a third basic module, a seventh special module, a second special module and three third special modules, and assemble them as follows:

[0082] (1) Insert the long tube marked -NH in the second special module into the upper right hole of the seventh special module;

[0083] (2...

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Abstract

The invention provides a modular assembly peptide chain space structure model, the model includes a plurality of first basic modules and a plurality of second basic modules. The present invention replaces the traditional ball and stick model by making the peptide plane into a plane structure, and makes the imino end and the carbonyl end detachable, and makes the link point Cα of the adjacent peptide plane into a spherical model as a connecting hub, and uses a sleeve The tube connection replaces the ball-and-stick connection, which can intuitively display the relationship between each atom of the peptide plane and the adjacent chemical bonds. It can also withstand repeated rotation without loosening, and the conformation is always stable. In this way, the two dihedral angles of the peptide plane can be directly measured or obtained directly. The present invention builds a realistic model for teachers based on theoretical data, simplifies, three-dimensionalizes, realizes, and vividizes teaching, facilitates teachers' teaching, improves students' learning interest, and deepens understanding and mastering of difficult knowledge.

Description

technical field [0001] The invention relates to a modular assembly peptide chain space structure model, which belongs to the technical field of teaching and scientific research tools. Background technique [0002] Proteins, which are ubiquitous in the biological world, are the most important biomacromolecules in organisms, the basic material basis of life activities, and perform different physiological functions. Through the research on the structure and function correlation of a large number of proteins, it is found that proteins with different biological functions contain different spatial structures; the specific spatial conformations of proteins in vivo are closely related to their special physiological functions. Therefore, studying the structure of a protein is crucial to studying its function. [0003] Protein molecules are biological macromolecules formed by many amino acids connected by peptide bonds, and play important biological functions in the life activities o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G09B23/26
CPCG09B23/26
Inventor 彭亚会李冀宏惠洋常志强吕桂香王大勇
Owner HARBIN MEDICAL UNIVERSITY