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Purpose of trichosanatine to resisting pulmonary fibrosis

A kind of technology of pulmonary fibrosis and terylene alkaloid, which is applied in the field of medicine and can solve the problems such as reports on pulmonary fibrosis resistance that have not been seen

Active Publication Date: 2020-07-28
江西北正人体组织样本库有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the anti-pulmonary fibrosis of Trichophyllin

Method used

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  • Purpose of trichosanatine to resisting pulmonary fibrosis
  • Purpose of trichosanatine to resisting pulmonary fibrosis

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Experimental program
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Embodiment Construction

[0015] The substantive content of the present invention will be described in detail below in conjunction with the embodiments, but the protection scope of the present invention is not limited thereto.

[0016] 1. Experimental materials

[0017] Human embryonic lung fibroblasts HFL1 were purchased from ATCC.

[0018] Fetal bovine serum and F12K medium were purchased from Gibco, USA.

[0019] The purity of trichophyllin base is ≥98.5%.

[0020] 2. Experimental method

[0021] 1. Cell culture

[0022] Human embryonic lung fibroblasts HFL1 were incubated with F12K medium containing 10% fetal bovine serum and 1% double antibody at 37°C, 5% CO 2 Cultivate in a constant temperature incubator. After the cells cover the bottom of the culture bottle, digest and passage.

[0023] 2. MTT method to determine the effect of drugs on the proliferation of human embryonic lung fibroblasts HFL1

[0024] Human embryonic lung fibroblasts HFL1 in the logarithmic growth phase were taken and di...

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Abstract

The invention discloses purpose of trichosanatine to resisting pulmonary fibrosis. The experiment results prove that the trichosanatine can effectively restrain proliferation and migration of human embryo lung fibroblasts HFL1, has obvious dosage effects, and has prospects that the trichosanatine can be developed into medicines for treating pulmonary fibrosis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the anti-pulmonary fibrosis application of trichophyllin. Background technique [0002] Pulmonary fibrosis is the end-stage change of many chronic interstitial lung diseases, and its pathology is characterized by excessive deposition of extracellular matrix and destruction of normal lung tissue structure. Due to the aggravation of air pollution and the increase of aging population, its prevalence and incidence have increased significantly in the past few decades, and it has become a problem that cannot be ignored in lung diseases. The mechanism of pulmonary fibrosis is complex and diverse, and has not yet been fully elucidated. Currently, pathological mechanism studies are mainly focused on the cells involved in the process of pulmonary fibrosis. [0003] Human embryonic lung fibroblast HFL1 is a mature cell model that has been found to be resistant to pulmonary fibrosis. ...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61P11/00
CPCA61K31/216A61P11/00
Inventor 陈茜许泽
Owner 江西北正人体组织样本库有限公司
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