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Automatic typing method based on human intestinal flora

A technology of intestinal flora and typing methods, applied in biostatistics, bioinformatics, instruments, etc., can solve the problems of incomplete display of results, too simple analysis results, lack of corresponding visual display content of data, etc.

Pending Publication Date: 2020-08-11
SHANGHAI OE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (1) Enterotype identification is not clear: the enterotype identification method for each clustering result is not clear;
[0006] (2) The result display is incomplete: the analysis result is too simple, the data mining is not deep enough, and there is a lack of visual display content corresponding to the data

Method used

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  • Automatic typing method based on human intestinal flora
  • Automatic typing method based on human intestinal flora
  • Automatic typing method based on human intestinal flora

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Embodiment

[0059] In order to demonstrate the practicability of the technical solution claimed in the present invention, the following uses the application of human intestinal bacterial metagenomic data in different countries as an example to further illustrate the practical application of the present invention. It should be noted that this embodiment is only for More clearly embodying the spirit of the technical solution of the present invention does not represent a limitation of the technical solution of the present invention, and all technical solutions that conform to the spirit of the present invention are within the scope of protection of this patent.

[0060] Take the application of human intestinal bacterial metagenomic data in different countries as an example:

[0061] Download the initial data set containing 33 samples, download address: https: / / enterotype.embl.de / MetaHIT_SangerSamples.genus.txt. This dataset contains the genus-level abundance tables of human gut microbes in d...

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Abstract

The invention discloses an automatic typing method based on human intestinal flora. According to the invention, clustering results are grouped by adopting a LEfSe mode, Biomarker screening is conducted, and then specific intestine types are determined; obtained results are comprehensive and comprise involved clustering graphs, Biomarker screening and intestinal type boxplot graph display; all theanalysis results can be automatically sorted out, summarizing and statistics are automatically conducted on the results after each step of analysis is completed, and visualization is realized; and alloperation steps can be traced back, so error query is facilitated, and if errors are analyzed and reported, corresponding error reporting log information can be obtained.

Description

technical field [0001] The invention relates to the field of high-throughput microbial sequencing, in particular to an automatic typing method based on human intestinal flora. Background technique [0002] In 2011, a European scientific research institution analyzed the composition of intestinal microbes of 22 Europeans by using the difference of a bacterial gene, and identified the different composition of the microbial ecosystem between each individual and the same individual. Moreover, they compared the microbial ecosystem composition patterns of these Europeans with previously discovered patterns of microbial ecosystem composition in Japanese and Americans. It turns out that these microbial ecogroups are not randomly combined. The microbial ecogroups can be roughly divided into three types in all the tested populations, also known as enterotypes. Scientists divide them into three types: Bacteroides, Prevotella and Ruminococcus mean that they contain more Bacteroides, Pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B40/30
CPCG16B40/30
Inventor 王树伟肖云平史贤俊林博张建明
Owner SHANGHAI OE BIOTECH CO LTD
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