Quick detection and analysis method for antihistamine drugs in water body
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An analysis method and antihistamine technology are applied in the field of detection and analysis of antihistamine drugs, which can solve the problems of high cost and complicated process, and achieve the effects of high accuracy, simple method and accurate result.
Active Publication Date: 2020-08-18
SHANGHAI UNIV
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[0005] In order to solve the problems of the prior art, the purpose of the present invention is to overcome the deficiencies in the prior art and provide a rapid detection and analysis method for antihistamines in water , can pretreat the environmental water body to improve the technical problems of complex process and high cost of existing treatment methods
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Embodiment 1
[0028] In the present embodiment, a rapid detection and analysis method of antihistamines in water bodies, the recovery rate experiment of standard addition, adopts the internal standard method to detect the recovery rates of antihistamines in natural water bodies, comprising the following steps:
[0029] a. Sample pretreatment:
[0030] The water body samples were coarsely filtered three times and finely filtered three times; three groups of parallel samples were set up, each group of water samples was taken 250ml, and the concentration of 20ppb cetirizine-d8 and diphenhydramine-d3 solutions were added to each group of water samples for a total of 1mL, mix well;
[0031] b. Use a solid phase extraction column for enrichment and purification:
[0032] The specific process of passing through the column is as follows: first, activate the solid phase extraction column with 5mL of methanol, then pass the filtered 200mL water sample through the column at a speed of 2ml / min, and th...
Embodiment 2
[0044] This embodiment is basically the same as Embodiment 1, especially in that:
[0045] In this example, the concentration of antihistamines in actual samples is measured, and 5 water samples in the environment are randomly collected, pretreated using the method of step a of Example 1, and then using the solid phase extraction method of step b of Example 1 Perform purification and enrichment, and then use the high performance liquid chromatography-mass spectrometry method in step c of Example 1 to analyze and detect the actual concentration of the target substance in the sample. The specific detection process is as follows:
[0046] In the present embodiment, a rapid detection and analysis method of antihistamines in water bodies, the recovery rate experiment of standard addition, adopts the internal standard method to detect the recovery rates of antihistamines in natural water bodies, comprising the following steps:
[0047] a. Sample pretreatment:
[0048] The water bo...
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Abstract
The invention discloses a quick detection and analysis method for antihistamine drugs in a water body. The method can be used for detecting drugs for treating allergic diseases, and six antihistaminedrugs, including cimetidine, diphenhydramine, cetirizine, fexofenadine, chlorpheniramine and ranitidine, in a water body can be efficiently and quickly detected at the same time by combining a solid-phase extraction small column with a high performance liquid chromatography-mass spectrometry method. The method comprises the following steps: filtering a water sample, and adding an internal standardsubstance; extracting and purifying six statins in the sample by using a small solid-phase extraction column; and detecting the content of a target object in the water sample by using a high performance liquid chromatography-mass spectrometer. The method has the advantages of simple water sample treatment steps, convenient operation and good stability, and can quickly obtain the sample suitable for detection of the liquid chromatograph-mass spectrometer; the sample pretreatment cost is low, the detection can be completed by utilizing common consumables in a laboratory, the detection speed ishigh, the automation degree is high, the response is sensitive, and popularization and application are facilitated.
Description
technical field [0001] The invention relates to a detection method for drugs for treating allergic diseases, in particular to a detection and analysis method for antihistamine drugs, which is applied to the technical field of trace detection of organic pollutants in water bodies. Background technique [0002] With the progress and development of modern medicine, a large amount of drugs are produced and consumed worldwide every year for the prevention and treatment of human and animal diseases. These drugs enter natural water bodies and bodies of water through a variety of routes. The most common way is the discharge of industrial sewage near the pharmaceutical factory and the discharge of domestic sewage caused by the metabolism of human and animal organisms. After the relevant literature research, it has been detected that there are certain concentrations of drugs and their metabolites in the sewage and the environment. Although their concentration levels are several order...
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