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A kind of green preparation method of nitroglycerin

A technology of nitroglycerin and nitroglycerin dichloromethane, which is used in the preparation of nitrate esters, pharmaceutical formulations, instruments, etc.

Active Publication Date: 2021-04-20
启东市新晨企业管理咨询有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This hazardous property is the most important obstacle to the production of nitroglycerin

Method used

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  • A kind of green preparation method of nitroglycerin
  • A kind of green preparation method of nitroglycerin
  • A kind of green preparation method of nitroglycerin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Preparation of 10% Nitroglycerin in Dichloromethane Solution

[0074] Concentrated sulfuric acid and fuming nitric acid are mixed at a speed ratio of 1:1 through the microreactor chip (1); glycerol and methylene chloride are input into the mixer (2) at a speed ratio of 0.2:2, and the microreactor chip (1 ) mixed acid solution and the solution of the mixer (2) are input into the microreactor chip (3), (4), (5) with the speed ratio of 2:2.75, and the retention time of the reaction solution in the microreactor is 10min to 30min, the reaction solution is input from the microreactor (5) to the Zaiput liquid-liquid separator (6), the acid solution is input to the waste liquid processor, the organic phase is mixed with water to the input mixer (7), and then input to the Zaiput liquid-liquid Separator (8), the water phase is input to the waste liquid processor, the organic phase and saturated salt solution are input to the Zaiput liquid-liquid separator (9), the water phase is ...

Embodiment 2

[0076] Green granules of nitroglycerin

[0077] A 10% concentration of nitroglycerin dichloromethane solution (10 ml) was pumped into a hot-melt extruder, 9 grams of lactose granules were added, granulated in a wet granulation mode, and vacuum-dried to obtain green granules of nitroglycerin.

Embodiment 3

[0079] Green freeze-dried granules of nitroglycerin (1)

[0080] 10% nitroglycerin dichloromethane solution 20 ml, polyvinylpyrrolidone 5 grams, lactose 18 grams; add appropriate amount of water for injection, slowly add 0% nitroglycerin dichloromethane solution, polyvinylpyrrolidone, lactose, and stir until After complete mixing, stir the bag for about 2-4 hours; vacuum freeze-dry to obtain green freeze-dried granules of nitroglycerin (1).

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Abstract

The invention relates to a green preparation method of nitroglycerin. The present invention is based on the micro-reactor of Nobel Explosives Company, according to the specific process of the continuous production of raw materials and preparations of nitroglycerin, through arduous innovation, achieved unexpected achievements in the continuous production of green preparations of nitroglycerin The progress has achieved green, safe and risk-free synthesis in the preparation of key APIs, and the subsequent integrated production of combined APIs and nitroglycerin preparations. This process is the first in China and is encouraged by global regulatory authorities. It is the general trend of drug production. .

Description

technical field [0001] The invention belongs to the field of chemical synthesis, and in particular relates to a green preparation method of nitroglycerin. Background technique [0002] Angina pectoris is a clinical syndrome characterized by paroxysmal chest pain or chest discomfort caused by coronary artery insufficiency and acute temporary ischemia and hypoxia of the myocardium. Nitroglycerin can directly relax vascular smooth muscle, especially small vascular smooth muscle, dilate peripheral blood vessels, reduce peripheral resistance, reduce cardiac output, reduce cardiac load, reduce myocardial oxygen consumption, and thus relieve angina. Nitroglycerin can promote the formation of collateral circulation. Take 1 tablet sublingually, it will take effect within 2-3 minutes, and the effect will last for about 30 minutes. [0003] Nitroglycerin, also known as glyceryl trinitrate, is formed by nitration of glycerin. The reaction equation is as follows: [0004] [0005]...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C201/02C07C203/06A61K31/21A61K9/16A61K9/08A61P9/10G01N30/02G01N30/74
CPCA61K9/08A61K9/1623A61K9/1635A61K9/1652A61K31/21A61P9/10C07C201/02G01N30/02G01N30/74G01N2030/027G01N2030/884C07C203/06
Inventor 张志祥
Owner 启东市新晨企业管理咨询有限公司
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