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A kind of 11-o-monogroxime ester derivative as an antioxidant of skin care products and a kind of skin care products

A technology of skin care products and antioxidants, which is applied in the field of natural product transformation, can solve problems such as unknown effects and no 11-O-mogrosinol oxime ester derivatives, and achieve natural and harmless ingredients, improve skin aging, and protect skin. skin effect

Active Publication Date: 2021-02-05
HUNAN HUACHENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in these documents, Luo Han Guo extract is directly used as a component of skin care products, and its function is unknown, and mogroside is generally used as the main active ingredient. At present, there is no 11-O-mogrosvenosa alcohol oxime ester derivative. Related reports

Method used

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  • A kind of 11-o-monogroxime ester derivative as an antioxidant of skin care products and a kind of skin care products
  • A kind of 11-o-monogroxime ester derivative as an antioxidant of skin care products and a kind of skin care products
  • A kind of 11-o-monogroxime ester derivative as an antioxidant of skin care products and a kind of skin care products

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0039] The preparation of preparation example formula (I) compound:

[0040] (1) Oximation and post-treatment: Take 23.8g of 11-O-mogrosidenol, dissolve it in 150ml of absolute ethanol, add 3.94g of hydroxylamine phosphate (containing 0.06mol of hydroxylamine) and 11g of diethylamine, and react under reflux at 85°C for 6 hours. After the reaction was tested by silica gel TLC, concentrated under reduced pressure until the solid content of the concentrated solution was 30%, cooled the concentrated solution to a temperature of 8 ° C, stirred at a speed of 10 r / min, crystallized for 20 hours, filtered with suction, and dried to obtain 11-oxime -Mogrosanol 22.6g.

[0041] (2) Esterification and post-treatment: Take 20.2g of 11-oxime-mogrogol, dissolve it in 150ml of dichloromethane, add 8.8g of diethylamine, add 8.4g of benzoyl chloride dropwise at -10°C, and stir at 0°C for reaction 6 hour; after the silica gel TLC test reaction finished, the reaction solution was poured into ice...

Embodiment 1

[0045] The skin care product formula of embodiment 1 is as follows:

[0046]

[0047]

[0048] 1) Take the above-mentioned substances according to the above-mentioned formula;

[0049] 2) Preparation of oil phase mixture: formula (I) compound, squalene, glycerin, butylene glycol, propylene glycol, oleic acid ester, polysorbate, hydrogenated lecithin, polydimethylsiloxane, natol gum , monoglyceride laurate, and Luba gum are added to absolute ethanol, and stirred evenly at 50-60°C;

[0050] 3) Prepare the water phase mixture, add sodium alginate, dipotassium glycyrrhizinate, lavender oil, and sodium hyaluronate into the water, and stir evenly;

[0051] 4) Add the oil phase mixture obtained in step 2) to the water phase mixture obtained in step 3) at 50-60°C, stir, emulsify, and homogenize to obtain an ointment-like substance.

Embodiment 2

[0053] The skin care product formula of embodiment 2 is as follows:

[0054]

[0055]

[0056] 1) Take the above-mentioned substances according to the above-mentioned formula;

[0057] 2) Preparation of oil phase mixture: formula (I) compound, squalene, glycerin, butylene glycol, propylene glycol, glyceryl monostearate, alkyl glucoside, polydimethylsiloxane, natto gum, lauryl Add monoglyceride and isopropyl myristate to absolute ethanol, and stir evenly at 50-60°C;

[0058] 3) Prepare the water phase mixture, add potassium lauryl phosphate, sodium alginate, dipotassium glycyrrhizinate, rose essential oil, and sodium hyaluronate into the water, and stir evenly;

[0059] 4) Add the oil phase mixture obtained in step 2) to the water phase mixture obtained in step 3) at 50-60°C, stir, emulsify, and homogenize to obtain an ointment-like substance.

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Abstract

The present invention provides a 11‑O‑mogroxime alcohol oxime ester derivative represented by formula (I) as an antioxidant for skin care products and a skin care product comprising the compound of formula (I) as an antioxidant active ingredient. After compounding the compound shown in the formula (I) with squalene, as an antioxidant of skin care products, it has played a synergistic effect, and the antioxidant capacity of skin care products, especially the lasting antioxidant capacity, has been significantly improved. The skin care product containing the compound of formula (I) provided by the invention has natural and harmless ingredients, can effectively protect the skin, and can obviously improve skin aging after use.

Description

technical field [0001] The invention relates to the field of natural product transformation, in particular to a skin care product containing 11-O-monogroxime ester derivatives and squalene. Background technique [0002] Luo Han Guo is a unique medicinal and edible plant in my country. It is rich in various nutrients and bioactive substances such as flavonoids, polysaccharides, and polyphenols. Mogroside, especially mogroside V is currently the most popular sweetener to replace sucrose. It is popular in European and American markets for its high sweetness and low calorie characteristics. Some literatures have studied the biological activity of mogroside, especially the antioxidant effect, and found that mogroside V has a certain antioxidant capacity, and has a certain scavenging effect on hydroxyl and superoxide anion free radicals. It is generally believed that mogroside has antioxidant activity because the hydrogen atoms on the aglycon have certain activity and can combine...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J41/00A61K8/63A61K8/31A61Q19/08
CPCA61K8/31A61K8/63A61K2800/522A61Q19/08C07J41/0016
Inventor 李伟黄华学
Owner HUNAN HUACHENG BIOTECH
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