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Systems and methods for preventing, mitigating, and/or treating dementia

A technology for dementia, visual stimulation, used in therapy, light therapy, physical therapy, etc.

Inactive Publication Date: 2020-08-21
MASSACHUSETTS INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even existing drugs like acetylcholinesterase inhibitors (eg, donepezil and rivastigmine) and N-methyl-D-aspartate (NMDA)-receptor antagonists (eg, memantine) also showed only a slight cognitive benefit

Method used

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  • Systems and methods for preventing, mitigating, and/or treating dementia
  • Systems and methods for preventing, mitigating, and/or treating dementia
  • Systems and methods for preventing, mitigating, and/or treating dementia

Examples

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Embodiment Construction

[0044] Auditory and visual gamma entrainment (GENUS) using a combination of sensory stimuli unexpectedly generated positive physiological and behavioral changes not observed with visual or auditory GENUS alone. The positive effects on the brain were not limited to the auditory cortex (AC) and hippocampus (HPC), but extended to eliciting microglial cluster responses in the medial prefrontal cortex (mPFC) and reducing amyloid load throughout the neocortex . Furthermore, the effects of the combined auditory and visual GENUS were observed on a shorter time scale (on the order of weeks). Combined auditory and visual GENUS for about a week improves Alzheimer's disease (AD) lesions in brain regions spanning large circuit networks. In particular, combined auditory and visual GENUS significantly reduced amyloid burden in the AC, visual cortex (VC), hippocampal subregion CA1, and mPFC. Combined auditory and visual GENUS produces microglial cluster responses and reduced amyloid in the ...

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Abstract

Devices, systems, and methods for a treating dementia or Alzheimer's disease in a subject in need thereof. In one example, combined auditory and visual stimuli having a frequency of about 20 Hz to about 60 Hz, and more specifically about 40 Hz, are non-invasively delivered to the subject to induce synchronized gamma oscillations in at least one brain region of the subject. In particular, pursuantto various treatment and exposure protocols, combined auditory and visual stimulation (as opposed to auditory or visual stimulation alone) promotes a microglia response in the medial prefrontal cortex(mPFC). More generally, combined auditory and visual stimulation induces an extended microglia clustering response in the auditory cortex, the visual cortex, and the mPFC.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority from each of the following U.S. Provisional Applications: Serial No. 62 / 570,250, filed October 10, 2017, and entitled "NEUROPROTECTIVE EFFECTS OF COMBINED SENSORY STIMULATION" (Attorney Docket No. MITX-9699 / 00US) and, Serial No. 62 / 570,929, filed October 11, 2017, and entitled "GAMMAENTRAINMENT BINDS HIGHER ORDER BRAIN REGIONS AND OFFERS NEUROPROTECTION" (Attorney Docket No. MITX-0070 / 00US). Each of these provisional applications is hereby incorporated by reference in its entirety. [0003] Statement of Government Support [0004] This invention was made with US Government support under Grant No. RF1 AG047661 awarded by the National Institutes of Health. The US Government has certain rights in this invention. Background technique [0005] Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by declines in memory, orientation, and reasoning. ...

Claims

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Application Information

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IPC IPC(8): A61H23/00A61M21/00A61N5/06
CPCA61N5/0618A61N5/062A61N5/0622A61N2005/0651A61N2005/063A61N2005/0647A61N2005/0667A61M21/00A61M2021/0022A61M2021/0027A61M2021/0044A61M2210/0693A61N2005/0648A61M2205/42A61M2205/05A61N2005/0626
Inventor L-H·蔡A·J·马托雷尔H-J·苏E·博伊登
Owner MASSACHUSETTS INST OF TECH
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