Application of protein CbAE with broad-spectrum antiviral function

Abstract

The invention discloses an application of a protein CbAE with a broad-spectrum antiviral function. The protein CbAE sequentially comprises a segment 1-segment 12, wherein the amino acid sequences of the segment 1 to the segment 12 are respectively as shown in the 72nd to 82nd positions, the 98th to 107th positions, the 109th to 114th positions, the 184th to 190th positions, the 218th to 242nd positions, the 232nd to 238th positions, the 273th to 283th positions, the 315 to 319 th positions, the 339 to 344 th positions, the 389 to 393 th positions, the 419 to 423 th positions, and the 425 to 429 th positions from the N end of SEQ ID NO: 2. Experiments prove that the fusion protein CbAE-1 and the fusion protein CbAE-2 can significantly inhibit novel coronavirus pseudo, novel coronavirus, HIVpseudo, DENV-2, ZIKV and HSV-1. The method has an important application value.

Description

technical field

[0001] The invention belongs to the field of biotechnology, and in particular relates to the application of a protein CbAE with broad-spectrum antiviral function. Background technique

[0002] Coronaviruses are a type of enveloped, single-stranded positive-sense RNA virus, named for the crown-like shape of virus particles under an electron microscope. The host range of coronaviruses mainly includes birds and mammals. So far, seven coronaviruses that can infect humans have been identified, including SARS virus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and the new The emergence of coronavirus (SARS-CoV-2) has posed a great threat to the world's economic health. The novel coronavirus belongs to the family Coronaviridae and belongs to the genus Coronavirus. After infecting humans, it can cause symptoms of varying degrees, with fever, fatigue, and dry cough as the main manifestations. In severe cases, pneumonia, acute respiratory distres...

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