Testing method for treating AIS patients by virtue of melatonin passage regulating factors
A technology of regulating factors and testing methods, which is applied in the determination/testing of microorganisms, biochemical equipment and methods, etc.
Pending Publication Date: 2020-08-25
孙欣
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[0006] The purpose of the present invention is to solve the defects existing in the existing technical field of juvenile healthy development research, and to study the temporal correlation between melatonin receptor expression and bone density change in bone marrow mesenchymal stem cells of juvenile idiopathic scoliosis patients. In order to further clarify the occurrence regularity of bone mineral density changes in the course of AIS patients, provide a diagnosis and treatment basis for clinical treatment of AIS bone mineral density changes, and provide reliable evidence for understanding the pathogenesis of AIS, a melatonin pathway regulator is proposed. Test method for treating AIS patients
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[0026] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention.
[0027] as attached figure 1 Shown, a kind of testing method of melatonin pathway regulation factor treatment AIS patient, specifically comprises the following steps:
[0028] S1, the pre-collected test data of different periods of non-AIS patients were used as controls;
[0029]In S1, the collected test data of non-AIS patients in different periods adopts the sampling method, and collects the average value of the diversified test data as the control data to eliminate the influence of special data, and selects patients who meet the diagnostic criteria of AIS. Informed consent, the average age of the patients and the average Cobb angle of scoliosis were calculated. Th...
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The invention discloses a testing method for treating AIS patients by virtue of melatonin passage regulating factors in the technical field of research of health development of adolescents. The methodcomprises the following steps: firstly, collecting test data of non-AIS patients in different time periods as a control in advance; secondly, carrying out grouping according to conditions of the AISpatients, collecting clinical experiment data of the grouped AIS patients, separating human mesenchymal stem cells of the AIS patients in different time periods, and carrying out in-vitro culture according to preceding grouping; and finally, testing mRNA expression of receptors MI1 and MT2 extracted from each group of the human mesenchymal stem cells cultured in vitro. By virtue of the testing method for treating the AIS patients by virtue of the melatonin passage regulating factors, a novel clinical preventing-treating scheme is provided for treating the AIS patients by virtue of melatonin receptor stimulants and relevant melatonin passage regulating factors.
Description
technical field [0001] The invention belongs to the technical field of adolescent health development research, and in particular relates to a test method for treating AIS patients with melatonin pathway regulation factors. Background technique [0002] Adolescent idiopathic scoliosis (adolescentidiopathic scoliosis, AIS) is a complex three-dimensional spinal deformity, mostly occurs in adolescent girls, its incidence rate is about 2% to 4%, the etiology is still unclear. AIS is one of the most common spinal deformities in adolescents. At present, the damage of AIS to patients' quality of life and mental health, as well as the impact of this damage on clinical efficacy, are one of the focuses of colleagues in various countries. Melatonin is a neuroendocrine hormone secreted by the pineal gland. The relationship between melatonin and its receptors and idiopathic scoliosis is a hotspot in the etiology research of AIS. Studies have found that the melatonin signaling pathway is ...
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IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/158C12Q2600/106
Inventor 孙欣王朝军魏波彭智恒傅青龙
Owner 孙欣