Application of dehydrodeacetoxychamomile or deacetylchamomile ketone in preparation of hypoglycemic and hypolipidemic drugs

A technology of acetoxymamethrin and acetylmamethrin, which is applied in the field of medicine and can solve problems such as no reports on the activity of dehydrodesacetoxymamethrin or deacetylmatricone

Inactive Publication Date: 2020-09-01
HEBEI UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Dehydrodesacetoxymamethrin or desacetylmamethrin are two compounds isolated from Artemisia argyi (Artemisia Artemisiae Chemical Constituents Research, Chinese Herbal Medicine, Vol. 50, No. 8, April 2019), which have not been seen so far. Report on the Activity of Dehydrodesacetoxymamethrin or Desacetylmamethrin in Lowering Blood Sugar and Blood Lipid

Method used

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  • Application of dehydrodeacetoxychamomile or deacetylchamomile ketone in preparation of hypoglycemic and hypolipidemic drugs
  • Application of dehydrodeacetoxychamomile or deacetylchamomile ketone in preparation of hypoglycemic and hypolipidemic drugs
  • Application of dehydrodeacetoxychamomile or deacetylchamomile ketone in preparation of hypoglycemic and hypolipidemic drugs

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Embodiment Construction

[0015] The following describes the substantive content of the present invention in detail in conjunction with the drawings and embodiments, but does not limit the protection scope of the present invention.

[0016] 1. Experimental materials

[0017] 1. Reagents

[0018] Orlistat (CAS: 96829-58-2), 4-methylumbelliferyl oleate (CAS: 18323-58-5), pancreatic lipase (CAS: 9001-62-1), acarbose Sugar (CAS: 56180-94-0), α-glucosidase (CAS: 9001-42-7), p-nitrophenyl-α-D-glucopyranoside (CAS: 3767-28-0) were purchased from Sigma-Aldrich Company; ultrapure water was prepared by Milli-Q system; other chemicals were of analytical grade. The purity of the compounds Artemisia ketone A, dehydrodeacetylmamethrin and deacetylmamethrin is not less than 98%.

[0019] 2. Instrument

[0020] VICTOR Nivo microplate reader (PerkinElmer Instrument Co., Ltd.); XS205 DU electronic analytical balance (Mettler-Toledo Instrument Co., Ltd.); high-speed centrifuge (German Eppendorf AG); dry nitrogen blow...

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Abstract

The invention discloses an application of dehydrodeacetoxychamomile or deacetylchamomile ketone in preparation of hypoglycemic and hypolipidemic drugs. Blood sugar and blood fat serve as two importantindexes reflecting the health level of the human body and have important reference significance in disease treatment and health care. Therefore, keeping blood sugar and blood fat indexes stable becomes an important research direction for treating related diseases. It is found that the dehydrodeacetoxychamomile and the deacetylchamomile ketone have excellent alpha-glucosidase inhibitory activity and pancreatic lipase inhibitory activity, and therefore the dehydrodeacetoxychamomile and the deacetylchamomile ketone have the prospect of being developed into the hypoglycemic and lipid-lowering medicine.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the new application of the known compound dehydrodeacetylmamethrin or deacetylmamethrin, in particular to the preparation of dehydrodeacetylmamethrin or deacetylmamethrin in the preparation of hypoglycemic Application of lipid-lowering drugs. Background technique [0002] Blood sugar and blood lipids, as two important indicators reflecting the health level of the human body, have important reference significance in disease treatment and health care. Therefore, maintaining the stability of blood sugar and blood lipid indicators has become an important research direction for the treatment of related diseases. [0003] Dehydrodesacetoxymamethrin or desacetylmamethrin are two compounds isolated from Artemisia argyi (Artemisia Artemisiae Chemical Constituents Research, Chinese Herbal Medicine, Vol. 50, No. 8, April 2019), which have not been seen so far. Report on the activity of dehydrodeacet...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P3/10A61P3/06
CPCA61K31/365A61P3/06A61P3/10
Inventor 郭龙张丹王蕾侯芳洁景松松常雅晴杨贵雅
Owner HEBEI UNIV OF CHINESE MEDICINE
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