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Vaccine composition for porcine circovirus and porcine mycoplasma pneumonia and preparation method of vaccine composition

A technology for Mycoplasma suis pneumonia and porcine circovirus, which is applied in the directions of viral antigen components, viruses/phages, biochemical equipment and methods, etc., can solve the problems of heavy workload and time-consuming, and achieves reduction of workload and simplification of epidemic prevention procedures. Avoid the effects of most injection treatments

Pending Publication Date: 2020-09-15
JIANGSU ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The outbreak of porcine circovirus and porcine mycoplasma pneumonia in my country has brought huge economic losses to China's pig industry every year. However, a single vaccine needs to be injected in batches, which takes a lot of time and a lot of work. The vaccine combination has important significance for the prevention and control of two kinds of porcine viral diseases, and for these problems, here we propose a kind of vaccine combination of porcine circovirus and swine mycoplasma pneumonia and its preparation method

Method used

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  • Vaccine composition for porcine circovirus and porcine mycoplasma pneumonia and preparation method of vaccine composition
  • Vaccine composition for porcine circovirus and porcine mycoplasma pneumonia and preparation method of vaccine composition
  • Vaccine composition for porcine circovirus and porcine mycoplasma pneumonia and preparation method of vaccine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The proportion of the total amount of the inactivated porcine circovirus type 1 antigen is set to 15%, the proportion of the total amount of the inactivated Mycoplasma hyopneumoniae is set to 25%, and the total amount of acceptable carrier on the pig is The proportion of the amount is set to 42%, the proportion of the total amount of the vaccine adjuvant is set to 10%, and the proportion of the total amount of the serum is set to 8%.

[0035] First extract inactivated porcine circovirus type 1 antigen and inactivated mycoplasma hyopneumoniae;

[0036] adding the prepared inactivated porcine circovirus type 1 antigen and inactivated mycoplasma hyopneumoniae to acceptable carriers on pigs;

[0037] Then add the serum according to the proportion for mixing, and use ultrasonic wave for auxiliary vibration mixing;

[0038] Finally, add the vaccine adjuvant, oscillate and mix, and then perform disinfection treatment. After the treatment is completed, let it stand for 20 minu...

Embodiment 2

[0042] The proportion of the total amount of the inactivated porcine circovirus type 1 antigen is set to 15%, the proportion of the total amount of the inactivated Mycoplasma hyopneumoniae is set to 20%, and the total amount of acceptable carrier on the pig is The proportion of the amount is set to 45%, the proportion of the total amount of the vaccine adjuvant is set to 5%, and the proportion of the total amount of the serum is set to 10%.

[0043] First extract inactivated porcine circovirus type 1 antigen and inactivated mycoplasma hyopneumoniae;

[0044] adding the prepared inactivated porcine circovirus type 1 antigen and inactivated mycoplasma hyopneumoniae to acceptable carriers on pigs;

[0045] Then add the serum according to the proportion for mixing, and use ultrasonic wave for auxiliary vibration mixing;

[0046] Finally, add the vaccine adjuvant, oscillate and mix, and then perform disinfection treatment. After the treatment is completed, let it stand for 20 minu...

Embodiment 3

[0050]The proportion of the total amount of the inactivated porcine circovirus type 1 antigen is set to 10%, the proportion of the total amount of the inactivated Mycoplasma hyopneumoniae is set to 20%, and the total amount of acceptable carrier on the pig is The proportion of the amount is set to 50%, the proportion of the total amount of the vaccine adjuvant is set to 10%, and the proportion of the total amount of the serum is set to 10%.

[0051] First extract inactivated porcine circovirus type 1 antigen and inactivated mycoplasma hyopneumoniae;

[0052] adding the prepared inactivated porcine circovirus type 1 antigen and inactivated mycoplasma hyopneumoniae to acceptable carriers on pigs;

[0053] Then add the serum according to the proportion for mixing, and use ultrasonic wave for auxiliary vibration mixing;

[0054] Finally, add the vaccine adjuvant, oscillate and mix, and then perform disinfection treatment. After the treatment is completed, let it stand for 20 minu...

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Abstract

The invention discloses a vaccine combination of porcine circovirus and porcine mycoplasma pneumonia. The vaccine comprises an inactivated porcine circovirus type 1 antigen, inactivated mycoplasma hyopneumoniae, an acceptable carrier on a pig body, a vaccine adjuvant and serum, wherein the total amount of the inactivated porcine circovirus type 1 antigen accounts for 5-15%; the total amount of theinactivated mycoplasma hyopneumoniae accounts for 10-25%, the total amount of the acceptable carrier on the pig body accounts for 25-50%, the total amount of the vaccine adjuvant accounts for 5-10%,and the total amount of the serum accounts for 5-10%. By combining the two antigens, the porcine circovirus and mycoplasma hyopneumoniae can be treated at the same time, most injection treatment is avoided, the epidemic prevention procedure is simplified, and meanwhile the workload is reduced.

Description

technical field [0001] The invention relates to the technical field of veterinary vaccines, in particular to a vaccine combination of porcine circovirus and porcine mycoplasma pneumonia and a preparation method thereof. Background technique [0002] Porcine circovirus (porcine circovirus, PCV) belongs to the genus Circovirus in the family Circoviridae in taxonomy, and is one of the smallest known animal viruses. Virus particles have a diameter of 14-17nm, a 20-sided symmetrical structure, no envelope, and contain a covalently closed single-strand circular negative-strand DNA. The genome size is about 1.76kb. PCV is quite resistant to external physical and chemical factors. [0003] Mycoplasma pneumonia in swine is a chronic pneumonia caused by Mycoplasma hyopneumoniae, also known as porcine endemic pneumonia. , and tested to reproduce the disease, the pathogen was named M.hyopneumoniae after the report. [0004] The outbreak of porcine circovirus and porcine mycoplasma pn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/12A61P31/20A61K39/02A61P31/04
CPCA61K39/0241A61K39/12A61K2039/521A61K2039/5252A61K2039/54A61K2039/552A61K2039/70A61P31/04A61P31/20C12N2750/10034
Inventor 常晨
Owner JIANGSU ACAD OF AGRI SCI
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