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Method and device for compound delivery

A device and algorithm technology, applied in the fields of drug devices, therapeutic nebulizers, applications, etc., can solve problems such as slow PK, precipitation, and low-dose delivery

Inactive Publication Date: 2020-10-02
方特慕控股第一私人有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since aerosol particles with an aerodynamic particle size greater than 5 μm can collide in the oral cavity or upper airways, such particles may be too large to reach deep lungs, resulting in slower PK
Conversely, aerosol particles with a median aerodynamic particle size of less than 1 μm may be small enough to reach the deep lungs, but may be too light to settle under gravity and may be exhaled, which may result in low dose delivery

Method used

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  • Method and device for compound delivery
  • Method and device for compound delivery
  • Method and device for compound delivery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0367] Example 1: Effect of Variations in Air Flow Rate, Current, Heating Duration, and Heater Element Thickness on Particle Size of Aerosols Generated from Propylene Glycol Formulations.

[0368] This example describes how changes in certain parameters (i.e., air flow rate, current to the heater element, and thickness of the heater element) affect the size of aerosol particles generated by a test device designed to contain, for example, Components and / or parameters of the nicotine delivery devices described herein. Figure 26 shows a schematic diagram of the entire test setup, while Figures 27A-27D An alternate view of the test airway used in the test device is shown. The test stand had an air channel formed between a Delrin block (bottom) and a clear plexiglass sheet (top), the brass face of which was used to clamp and make electrical contact with the heater element. The heater element was a stainless steel foil of variable thickness (0.0005 inch (approximately 0.013 mm) or...

Embodiment 2

[0371] Example 2: Effect of Variations in Air Flow Rate, Current, Heating Duration and Heater Element Thickness on Particle Size of Aerosols Generated from Nicotine / Propylene Glycol Formulations.

[0372] This example describes how changes in certain parameters (ie, air flow rate and current to the heater element) affect the size of aerosol particles generated by the test device described in Example 1 from a 10% nicotine / propylene glycol formulation. Table 3 shows the results of varying the heater element thickness, air flow rate, current and heating duration on the particle size distribution. As shown in Table 3, when the air flow rate is changed while other parameters are kept constant, the higher the air flow rate, the smaller the average particle size (PSD).

[0373] table 3.

[0374]

[0375]

Embodiment 3

[0376] Example 3: Particle size range of aerosols generated from a test device using a heater element comprising a coil.

[0377] This example describes the use of Figure 26 and Figures 27A-27D Particle size of aerosols generated from PG formulations or 10% nicotine / PG formulations using test devices as shown and described in Example 1. In this embodiment, the heater element is a stainless steel coil comprising 3.5 turns and a 0.10 inch (approximately 2.54mm) diameter. The heater element is heated using 2.5 amps at an air flow rate of 4 liters / minute (approximately 6.7x10 -5 m 3 / s). Table 4 shows the results.

[0378] Table 4.

[0379]

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PUM

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Abstract

The invention relates to a method and device for compound delivery, and provides a method, device, system, and computer readable medium for delivering one or more compounds to a subject. The inventionalso describes a device that helps a smoker to start to smoke an electronic cigarette, a method for smoking / nicotine cessation, a device, a system, and a computer readable medium. A condensed aerosolgenerator, which is used to make a liquid preparation into condensed aerosol, comprises (a) a container filled with a liquid preparation; and (b) a channel with a heating element, an inlet, and an outlet.

Description

[0001] This application is a divisional application of the application dated November 27, 2013, the application number is 201380071459.4, and the title of the invention is "method and device for compound delivery". [0002] cross reference [0003] This application calls for 61 / 730,738 filed November 28, 2012, 61 / 794,601 filed March 15, 2013, 61 / 831,992 filed June 6, 2013, and Benefit of U.S. Provisional Application No. 61 / 887,045, filed October 4, 2013, which is hereby incorporated by reference in its entirety. Background technique [0004] There is a need for new methods and new devices for administering compounds, such as agents, to subjects. In particular, there is a need for methods and devices for delivering a compound to a subject wherein the compound is nebulized to fall within a specified particle size range. In some cases, particles within a specified size range can be efficiently delivered deep into the lung. For example, there is an urgent need for improved met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M11/04A61M15/06A61M16/00A24F40/10A24F40/485
CPCA61M15/0065A61M15/06A61M2016/0015A61M2205/3653A61M2205/8206A61M11/001A61M11/002A61M11/042A61M15/002A61M15/0066A61M15/0083A61M2205/3553A61M2205/3561A61M2205/3569A61M2205/3584A61M2205/3592A61M2205/502A61M2205/52A24B15/167Y02A90/10A24F40/10A24F40/485A61M11/041
Inventor 马丁·温斯利迈克尔·赫弗德杰弗里·威廉姆斯彼得·劳埃德
Owner 方特慕控股第一私人有限公司
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