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Photodynamic therapy devices, systems and methods

A technology of photodynamic therapy and lighting device, which can be used in phototherapy, radiotherapy, circuit devices, etc., and can solve problems such as long-term implantation incompatibility

Active Publication Date: 2020-10-02
NAT UNIV OF SINGAPORE
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  • Abstract
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Problems solved by technology

However, the clinical application of PDT is hampered by the low penetration of light through biological tissue, even at near-infrared wavelengths, which limits the treatment depth to less than 1 cm.
Currently, delivering light to deeper tissue regions relies on optical fibers inserted surgically or endoscopically, but their incompatibility with long-term implantation makes it possible to deliver only a single light dose

Method used

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  • Photodynamic therapy devices, systems and methods
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  • Photodynamic therapy devices, systems and methods

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Embodiment Construction

[0063] The present disclosure relates to a wireless photonic method for photodynamic therapy (PDT) that may enable on-demand photoactivation of photosensitizers deep within the body. A system including an implantable photonic device and a wireless power delivery system delivers therapeutic doses of light into tissue inaccessible to direct illumination. Miniaturized size (30mg, 15mm 3 ) device allows it to be implanted directly at the target site, where a specialized radiofrequency system wirelessly powers the device and monitors the light dose rate.

[0064] figure 1 A schematic diagram of the PDT method for treating a lesion is shown. First, implantable illumination device 110 is inserted into skin 102 of patient 104 proximate to target lesion 106 . Due to the small size of the implantable illuminator, the implantable illuminator 110 is compatible with minimally invasive implantation during standard clinical procedures such as open biopsy or during surgical tumor resection...

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Abstract

Wirelessly powered photodynamic therapy devices are disclosed and systems and methods using such devices are also disclosed. In an embodiment, a photodynamic therapy system comprises: an implantable illumination device comprising a light source configured to emit light having a spectrum which overlaps with an absorption peak of an absorption target and a receiver antenna coupled to the light source and configured to extract power from a radiofrequency power signal incident on the implantable illumination device; and a transmitter comprising an antenna, a powering module configured to generatea drive signal which causes the antenna to generate the radiofrequency power signal, and a dosimetry module coupled to the antenna and configured to detect a radiofrequency signal backscattered from the implantable illumination device and determine an indication of the power extracted by the implantable illumination device from the radiofrequency signal backscattered from the implantable illumination device.

Description

technical field [0001] The present disclosure relates to photodynamic therapy, and more particularly to photodynamic therapy devices, systems, and methods for wirelessly transmitting power to implantable lighting devices. Background technique [0002] Advances in understanding and engineering light-tissue interactions have enabled a class of targeted therapies with unparalleled spatiotemporal resolution. Photodynamic therapy (PDT) is a clinical example in which photosensitizing drugs known as photosensitizers are selectively activated by light to generate reactive oxygen species (ROS) that can be used to kill malignant cells. Other emerging treatments include photothermal therapy and photobiomodulation. However, the clinical application of PDT is hampered by the low penetration of light through biological tissue, even at near-infrared wavelengths, which limits the treatment depth to less than 1 cm. Currently, delivering light to deeper tissue regions relies on optical fibe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/06
CPCA61N5/062A61N2005/0612A61N5/0601A61N2005/0626H02J50/20H02J2310/23
Inventor 何思远张勇A·班萨尔杨丰瑗田曦
Owner NAT UNIV OF SINGAPORE
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