16 results about "Photo dynamic therapy" patented technology

The invention belongs to the technical field of photosensitive materials, and particularly relates to an aggregation-induced emission type photosensitizer as well as a preparation method and application thereof. The aggregation-induced emission type photosensitizer provided by the invention has a structure as shown in any one of formulas I-III. The aggregation-induced emission (AIE) photosensitizer has large Stokes shift, can emit light in a near infrared region I (NIR-I), and is beneficial to penetrating deep biological tissues and reducing light damage to the biological tissues; meanwhile, the AIE type photosensitizer has relatively strong I type active oxygen generation capability, and is expected to be used as a photosensitizer for photodynamic therapy. Formula I, Formula II and Formula III.

The present invention relates to a composition comprising a photosensitizer use in prevention or treatment of dermatological disease in a patient, wherein the composition is used in the following order of steps: (a) topical application or subcutaneous injection of said composition to an area of the skin of said patient, (b) exposure of at least said area of the skin to light with a wavelength spectrum similar or identical to sun light for a duration of 30 min to 5 hours, and (c) exposure of at least said area of the skin to light of a wavelength spectrum comprising only one maximum in the absorbance spectrum of said photosensitizer as well as to methods of treating dermatological disease using the outlined steps and kits of parts comprising such compositions and light sources suitable to apply the respectively indicated light.

An illumination device (100) for photodynamic therapy is provided, the illumination device comprising at least one electromagnetic radiation emitting unit (10), the at least one electromagnetic radiation emitting unit having at least one electromagnetic radiation source (1), the electromagnetic radiation source configured to generate radiation for irradiating an area of ​​an irradiation target during an illumination time, the irradiation target being located at a predetermined target position (300), the predetermined target position (300) being positioned at a distance relative to a radiation output area (11) of the electromagnetic radiation emitting unit (10), and the radiation generated by the at least one electromagnetic radiation source (1) exiting the electromagnetic radiation emitting unit (10) through the radiation output area (11) during operation of the illumination device (100).

A photodynamic therapy light delivery system can comprise a light source and a light delivery catheter, including an expandable distal section, to be advanced to a treatment area in a closed state, and to be expanded to form a flow channel, and configured to have an outer compliant portion to compliantly press against the treatment area; wherein the space between the blood flow channel and outer portion of the catheter can be filled with a balloon, inflated with a fluid transparent or translucent at the treatment wavelengths; a shaft and a proximal section, together configured to advance the expandable distal section to the treatment area, and to receive the light from the light source at the proximal section and to forward the light to the expandable distal section; and side-emitting optical fibers, positioned in the expandable distal section, to receive the light and to illuminate the treatment area.

The utility model relates to the technical field of laser hair driers, and discloses a laser hair drier integrated with photodynamic therapy, which comprises an outer shell, an air outlet is arranged on the outer shell, and a battery, a semiconductor laser, an optical fiber, a radiating block, a thermoelectric refrigeration sheet, a temperature sensor, a fan and a control panel are arranged in the outer shell. The input end of the optical fiber is in coupling connection with the semiconductor laser, the output end of the optical fiber faces the air outlet, the semiconductor laser is installed on the thermoelectric refrigeration sheet, and the thermoelectric refrigeration sheet is installed on the heat dissipation block; the temperature sensor is installed on the semiconductor laser, and airflow generated by the fan blows to the heat dissipation block and is exhausted from the air outlet. The control panel is electrically connected with the battery, the semiconductor laser, the thermoelectric refrigeration sheet, the temperature sensor and the fan; the utility model has the advantages of convenient to use, reduced user burden and convenient to carry.

The present invention discloses a preparation method and application of a bromine-containing cyclopentadienyl BODIPY photosensitizer, and provides a simple preparation method and application of a bromine-containing cyclopentadienyl BODIPY photosensitizer in photodynamic therapy. The photosensitizer is a novel bromine-containing hexavalent BODIPY. Its chemical structure is shown in Formula I. The BODIPY photosensitizer has a cyclopentadienyl structure and possesses the spectral properties of classic traditional BODIPY dyes. The BODIPY photosensitizer with this structure can deeply penetrate biological tissues under irradiation with a long-wavelength monochromatic light source; has low toxic side effects; and exhibits easy interstitial electron crossover, exhibiting efficient singlet oxygen generation and fluorescence emission capabilities, and can be applied to photodynamic therapy.

The invention belongs to the technical field of biomedical engineering and drug delivery, and particularly relates to photoresponsive polydopamine-based composite nanoparticles as well as a preparation method and application thereof. Aiming at the problems of high system toxicity, poor controllability and the like of a photosensitizer in the existing photodynamic therapy, the photosensitizer is synergistically constructed by a temperature-sensitive upper critical solution temperature polymer carrier and a polydopamine core, the photosensitizer is loaded through a physical adsorption effect, and a targeted neovascularization function is realized by modifying RGD (arginine-glycine-aspartic acid), so that the final LCPN is formed. The mPDA inhibits the activity of the photosensitizer through a fluorescence quenching effect, and the non-targeted phototoxicity in the circulation process is remarkably reduced; the polymer (P (NADAm-co-NPhAm)) is subjected to temperature control phase change under the triggering of near-infrared light, so that the controllable release of PS is realized. PS released by the LCPN is excited by near-infrared light at a target part to perform photodynamic therapy so as to accurately block new vessels, and meanwhile, an mPDA kernel can remove residual active oxygen and relieve inflammation of surrounding tissues.

The invention relates to the technical field of preparation and application of tumor diagnosis and treatment probes, and discloses an orthogonal near-infrared light driven imaging / membrane targeted photodynamic therapy probe and a method thereof.The surfaces of rare earth down-conversion nanoparticles are modified with mesoporous silicon doped with photosensitizer pheophorbide A and perfluorocarbon through a sol-gel method; and mixing the meso-porous silicon modified down-conversion nanoparticles with distearoyl phosphatidyl ethanolamine-PEG (Polyethylene Glycol) to finally obtain the orthogonal near-infrared light driven imaging / membrane targeted photodynamic therapy probe. The prepared nano-probe can achieve orthogonal near-infrared light driven imaging and photodynamic therapy under 980 nm laser and 808 nm laser respectively, a reasonable orthogonal near-infrared light excitation system is formed, meanwhile, solution, cell and living body level experiments show that the nano-probe is good in biocompatibility and good in photodynamic therapy effect, and the application range of the nano-probe is widened. The pyroptosis can be efficiently induced through a membrane targeting photodynamic therapy, and excellent treatment performance is shown in vitro and in vivo.

The present disclosure provides water-soluble and low-aggregation NIR- and SWIR-active small molecule polymethine dyes with improved properties for use in optical imaging, photothermal therapy, and photodynamic therapy.

The present invention relates to a method for synthesising a photosensitive polyethylene glycol (PEG) and methyl ether-poly(d,l-lactide) (PDLLA) polymer by tosylating its organic group. The photosensitive PEG-PDLLA polymer is functionalised by opening the Lactide monomer ring by polymerising and covalently bonding with the alcohol terminal group of PEG via an esterification with the tosylated organic group. The nanopolymer obtained using the disclosed method is suitable for controlled release processes of hydrophobic and hydrophilic active ingredients with specific delivery based on photodynamic therapy. The PEG-PDLLA-based nanopolymer obtained is able to encapsulate hydrophobic and hydrophilic active ingredients, configuring a nanocarrier with amphiphilic filler with high potential for photodynamic therapy. The method in turn involves nanoprecipitation by removing the organic solvent with optimal photo response properties to UV light.

An illumination system (1) for photodynamic therapy is provided, the illumination system comprising an illumination source (2) configured to emit electromagnetic radiation (3) to illuminate a target surface (4) during operation, and an electronic control unit (5), wherein the illumination source is configured such that the intensity of the electromagnetic radiation emitted by the illumination source is variable, wherein the electronic control unit is operably connected to the illumination source and is configured to control the operation of the illumination source in accordance with an illumination protocol during an illumination session performed with the illumination system, and wherein the illumination protocol comprises instructions to operate the illumination source in a plurality of different modes during the illumination session, said modes comprising: a) a first mode, wherein in the first mode the electronic control unit controls the operation of the illumination source such that the intensity of the electromagnetic radiation emitted by the illumination source is continuously or quasi-continuously increased from a base intensity B to a target intensity T over a first mode time interval, b) a second mode, wherein in the second mode the electronic control unit controls the operation of the illumination source such that the intensity of the electromagnetic radiation emitted by the illumination source is constant or substantially constant over a second mode time interval, and c) a third mode, wherein in the third mode the electronic control unit controls the operation of the illumination source such that the illumination source is operated such that a dark phase and an illumination phase are alternated over a third mode time interval, wherein the intensity of the electromagnetic radiation emitted by the illumination source is lower in the dark phase than in the illumination phase, or wherein in the dark phase the illumination source does not emit electromagnetic radiation, while in the illumination phase the illumination source emits electromagnetic radiation. Furthermore, a computer program product and a kit for treating a disease and a method for operating an illumination source and a method for treating a skin disease are provided.

The invention belongs to the technical field of medical material preparation, and particularly relates to a photodynamic-based composite material for treating periodontitis and a preparation method and application of the photodynamic-based composite material. The method comprises the following steps: dispersing sodium dodecyl benzene sulfonate, tin chloride pentahydrate and L-cysteine into a mixed solution of water and ethylene glycol, uniformly stirring, and carrying out hydrothermal reaction to obtain nanosheets; then mixing with sulfydryl-polyethylene glycol, and carrying out ultrasonic treatment to obtain tin disulfide nanosheets; the preparation method comprises the following steps: mixing a germanium oxide solution, a chromium nitrate nonahydrate solution, zinc nitrate hexahydrate, gallium nitrate hydrate and water, stirring in a dark place, adding ammonia water, continuously stirring uniformly, and carrying out a hydrothermal reaction to obtain long-luminescent nanoparticles; and finally, dissolving the tin disulfide nanosheets and the long luminous nanoparticles in water, stirring in a dark place, adding a methylene blue solution, and continuously stirring in a dark place, thereby obtaining the long luminous nano-particles. The composite material for treating periodontitis based on photodynamic therapy prepared by the invention can effectively improve the curative effect of the photodynamic therapy in periodontitis treatment.

To provide a new rotaxane-type photosensitizer exhibiting high light stability and enabling coexistence of suitable water solubility and cell membrane permeability.SOLUTION: A photosensitizer for photodynamic therapy containing a rotaxane-type reactive oxygen species generator, wherein the rotaxane-type reactive oxygen species generator is a [3]-rotaxane formed by being included by two cyclodextrins or derivatives thereof. Also provided is the photosensitizer which is an anticancer agent.SELECTED DRAWING: None

A light emitting device is a light emitting device for use in a photodynamic therapy. The light emitting device includes: a solid-state light-emitting element that emits primary light in which an energy density is 0.5 W / mm2 or more; and a wavelength converter including a first phosphor that emits first wavelength-converted light. The first wavelength-converted light has a light component across at least a whole of a wavelength range of 700 nm or more and less than 800 nm. Energy of fluorescence emitted from the wavelength converter is 100 mW or more. A medical device includes the light emitting device.

A method of exciting an organic salt in a cell is provided. The method includes contacting the cell with a composition including the organic salt, the organic salt having a photoactive ion and a counterion. The cell uptakes the organic salt, the organic salt is substantially free of a coating within the cell, and the organic salt is non-toxic to the cell in the dark. The method also includes exposing the cell to light having a first wavelength, wherein the organic salt absorbs the light having the first wavelength and the photoactive ion becomes excited.

A light irradiation device (100) for photodynamic therapy is provided with: a flexible substrate (101); and a light source unit that is disposed on the flexible substrate (101) and includes a first LED element (103a) having a peak wavelength in a range of 400-420 nm, a second LED element (103b) having a peak wavelength in a range of 500-520 nm, and a third LED element (103c) having a peak wavelength in a range of 625-645 nm.