30 results about "Photo dynamic therapy" patented technology

The invention discloses a preparation method of photoresponse COFs coated CeO2 nano-enzyme, and relates to the field of nano-materials. According to the invention, FePc, TAPP and 2, 5-dihydroxy-1, 4-phthalaldehyde are used for creating a core-shell material CeO2 (at) FePC / por-COF of photoresponse peroxidase based on COFs (Covalent Organic Frameworks), and the core-shell material CeO2 (at) FePC / por-COF is used for preparing the photoresponse peroxidase based on COFs. According to the invention, the highly ordered structural characteristic of the COFs material is utilized, so that the problem of fluorescence quenching caused by aggregation of traditional micromolecule photosensitizers (such as porphyrin, phthalocyanine and the like) in the use process is effectively solved. According to the present invention, the photoresponsive peroxidase activity is significant, and the chromogenic substrate of tetramethyl benzidine (TMB) can be effectively catalyzed; fePc is integrated into a COFs structure, so that the photoresponse activity of the COFs under near-infrared 808 nm is enhanced, and the COFs have excellent reactive oxygen species (ROS) generation capacity, and have great potential in the aspects of photodynamic therapy, antibacterial treatment, cell imaging and the like in biomedical application.

An illumination system (1) for photodynamic therapy is provided, the illumination system comprising an illumination source (2), which is configured to emit an electromagnetic radiation (3) to illuminate a target surface (4) during operation, and an electronic control unit (5), wherein the illumination source is configured such that the intensity of the electromagnetic radiation emitted by the illumination source can be varied, wherein the electronic control unit is operatively connected to the illumination source and configured to control operation of the illumination source according to an illumination protocol during an illumination session performed with the illumination system, and wherein the illumination protocol comprises instructions to operate the illumination source during the illumination session in a plurality of different modes, the modes comprising: a) a first mode, wherein, in the first mode, the electronic control unit controls operation of the illumination source such that the intensity of the electromagnetic radiation emitted by the illumination source is increased continuously or quasi-continuously from a base intensity B to a target intensity T within a first mode time interval, b) a second mode, wherein, in the second mode, the electronic control unit controls operation of the illumination source such that the intensity of the electromagnetic radiation emitted by the illumination source is constant or substantially constant for a second mode time interval, and c) a third mode, wherein, in the third mode, the electronic control unit controls operation of the illumination source such that the illumination source is operated such that darker phases and illumination phases alternate for a third mode time interval, wherein the intensity of the electromagnetic radiation emitted by the illumination source is lower in the darker phases than in the illumination phases, or wherein, in the darker phases the illumination source does not emit electromagnetic radiation whereas the illumination source emits electromagnetic radiation in the illumination phases. Furthermore, a computer program product and a kit for treating a disease are provided and a method for operating an illumination source and a method for treating a skin disease.

Provided is a light diffusion device which can irradiate light in a direction inclined with respect to the axial direction of a light transmission cable, and which has excellent degree of freedom in material selection for the desire of a device user, such as bioaffinity, cost, operability, and the like. This light diffusion device (1) for photoimmunotherapy or photodynamic therapy is provided with: a light transmission cable (10) that transmits light emitted by a laser oscillator and emits the transmitted light from an emission surface (12) of a tip section (11); a reflection member (30) having a refraction surface (31) that refracts the light emitted from the emission surface (12); and a resin tubular member (20) into which the optical transmission cable (10) and the reflective member (30) are inserted. Furthermore, the refracting surface (31) is disposed so as to be inclined with respect to the axial direction (X) of the optical transmission cable (10) at a position within the tubular member (20) at a predetermined distance from the emission surface (12), and emits the laser light (L) emitted from the emission surface (12) so as to be inclined with respect to the axial direction (X) of the optical transmission cable (10) at a predetermined angle or more.

To provide an illumination system, in particular for medical technical therapeutic and / or diagnostic systems.SOLUTION: An illumination system (1) includes at least one laser light source (10) and a light guide (30) which, at a proximal end, is connectable and / or assignable to the at least one laser light source. The illumination system has, at a distal end of the light guide, a diffuser element (40) which has a substantially radial, spherical emission characteristic. The diffuser element comprises at least one diffuser main body. The diffuser main body comprises an inorganic material, in particular a glass, a glass ceramic, a glass-like material, or a composite material of these materials, and advantageously at least one scattering element. A surface of the at least one diffuser main body is pore-free and smooth. Such an illumination system can be used in photodynamic therapy (PDT), photoimmunotherapy (PIT), and ophthalmic and dental fields.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of photosensitive materials, and particularly relates to an aggregation-induced emission type photosensitizer as well as a preparation method and application thereof. The aggregation-induced emission type photosensitizer provided by the invention has a structure as shown in any one of formulas I-III. The aggregation-induced emission (AIE) photosensitizer has large Stokes shift, can emit light in a near infrared region I (NIR-I), and is beneficial to penetrating deep biological tissues and reducing light damage to the biological tissues; meanwhile, the AIE type photosensitizer has relatively strong I type active oxygen generation capability, and is expected to be used as a photosensitizer for photodynamic therapy. Formula I, Formula II and Formula III.

The present invention relates to a composition comprising a photosensitizer use in prevention or treatment of dermatological disease in a patient, wherein the composition is used in the following order of steps: (a) topical application or subcutaneous injection of said composition to an area of the skin of said patient, (b) exposure of at least said area of the skin to light with a wavelength spectrum similar or identical to sun light for a duration of 30 min to 5 hours, and (c) exposure of at least said area of the skin to light of a wavelength spectrum comprising only one maximum in the absorbance spectrum of said photosensitizer as well as to methods of treating dermatological disease using the outlined steps and kits of parts comprising such compositions and light sources suitable to apply the respectively indicated light.

An illumination device (100) for photodynamic therapy is provided, the illumination device comprising at least one electromagnetic radiation emitting unit (10), the at least one electromagnetic radiation emitting unit having at least one electromagnetic radiation source (1), the electromagnetic radiation source configured to generate radiation for irradiating an area of ​​an irradiation target during an illumination time, the irradiation target being located at a predetermined target position (300), the predetermined target position (300) being positioned at a distance relative to a radiation output area (11) of the electromagnetic radiation emitting unit (10), and the radiation generated by the at least one electromagnetic radiation source (1) exiting the electromagnetic radiation emitting unit (10) through the radiation output area (11) during operation of the illumination device (100).

A photodynamic therapy light delivery system can comprise a light source and a light delivery catheter, including an expandable distal section, to be advanced to a treatment area in a closed state, and to be expanded to form a flow channel, and configured to have an outer compliant portion to compliantly press against the treatment area; wherein the space between the blood flow channel and outer portion of the catheter can be filled with a balloon, inflated with a fluid transparent or translucent at the treatment wavelengths; a shaft and a proximal section, together configured to advance the expandable distal section to the treatment area, and to receive the light from the light source at the proximal section and to forward the light to the expandable distal section; and side-emitting optical fibers, positioned in the expandable distal section, to receive the light and to illuminate the treatment area.

An optical diffusion device for photoimmunotherapy or photodynamic therapy comprises: a light transmission cable which transmits light emitted from a laser oscillator and which outputs the transmitted light from an output surface of a tip end part; a reflection member which has a refraction surface that refracts light output from the output surface; and a resin tube-shaped member into which the light transmission cable and the reflection member are inserted. The refraction surface is disposed in the tube-shaped member at a position which is a prescribed distance from the output surface, is inclined with respect to the axial direction X of the light transmission cable, causes laser light output from the output surface to be inclined by a prescribed angle or greater with respect to the axial direction of the light transmission cable, and outputs the laser light.

The present invention discloses a quantitative detection device and method for the spatial distribution of blood oxygen saturation in photodynamic therapy. White light emitted by a white light LED generates a fringe image with a specific spatial frequency after passing through a digital micromirror device. The fringe image is projected onto a biological tissue to be measured through a projection lens and a first polarizer. The biological tissue generates a diffuse reflection light signal under this illumination. The diffuse reflection light signal passes through a second polarizer and a liquid crystal tunable filter. The liquid crystal tunable filter only allows the diffuse reflection light signal with a specific wavelength to pass through under computer control. The diffuse reflection light signal passing through the liquid crystal tunable filter is incident on the target surface of a CMOS camera after passing through an imaging lens. The CMOS camera transmits the collected image information into a computer to complete the acquisition of image information. The present invention can obtain the spatial distribution and its changes of tissue oxygen content during the photodynamic reaction, providing a reference basis for evaluating the degree of photodynamic reaction and further optimizing and regulating photodynamic therapy parameters to improve the efficacy of PDT.

The utility model relates to the technical field of laser hair driers, and discloses a laser hair drier integrated with photodynamic therapy, which comprises an outer shell, an air outlet is arranged on the outer shell, and a battery, a semiconductor laser, an optical fiber, a radiating block, a thermoelectric refrigeration sheet, a temperature sensor, a fan and a control panel are arranged in the outer shell. The input end of the optical fiber is in coupling connection with the semiconductor laser, the output end of the optical fiber faces the air outlet, the semiconductor laser is installed on the thermoelectric refrigeration sheet, and the thermoelectric refrigeration sheet is installed on the heat dissipation block; the temperature sensor is installed on the semiconductor laser, and airflow generated by the fan blows to the heat dissipation block and is exhausted from the air outlet. The control panel is electrically connected with the battery, the semiconductor laser, the thermoelectric refrigeration sheet, the temperature sensor and the fan; the utility model has the advantages of convenient to use, reduced user burden and convenient to carry.

The present invention discloses a preparation method and application of a bromine-containing cyclopentadienyl BODIPY photosensitizer, and provides a simple preparation method and application of a bromine-containing cyclopentadienyl BODIPY photosensitizer in photodynamic therapy. The photosensitizer is a novel bromine-containing hexavalent BODIPY. Its chemical structure is shown in Formula I. The BODIPY photosensitizer has a cyclopentadienyl structure and possesses the spectral properties of classic traditional BODIPY dyes. The BODIPY photosensitizer with this structure can deeply penetrate biological tissues under irradiation with a long-wavelength monochromatic light source; has low toxic side effects; and exhibits easy interstitial electron crossover, exhibiting efficient singlet oxygen generation and fluorescence emission capabilities, and can be applied to photodynamic therapy.

The invention belongs to the technical field of biomedical engineering and drug delivery, and particularly relates to photoresponsive polydopamine-based composite nanoparticles as well as a preparation method and application thereof. Aiming at the problems of high system toxicity, poor controllability and the like of a photosensitizer in the existing photodynamic therapy, the photosensitizer is synergistically constructed by a temperature-sensitive upper critical solution temperature polymer carrier and a polydopamine core, the photosensitizer is loaded through a physical adsorption effect, and a targeted neovascularization function is realized by modifying RGD (arginine-glycine-aspartic acid), so that the final LCPN is formed. The mPDA inhibits the activity of the photosensitizer through a fluorescence quenching effect, and the non-targeted phototoxicity in the circulation process is remarkably reduced; the polymer (P (NADAm-co-NPhAm)) is subjected to temperature control phase change under the triggering of near-infrared light, so that the controllable release of PS is realized. PS released by the LCPN is excited by near-infrared light at a target part to perform photodynamic therapy so as to accurately block new vessels, and meanwhile, an mPDA kernel can remove residual active oxygen and relieve inflammation of surrounding tissues.

Illumination device for photodynamic therapy, the illumination device comprising at least one electromagnetic radiation emitting unit the at least one electromagnetic radiation emitting unit comprising at least one electromagnetic radiation source, the electromagnetic radiation source being configured to generate radiation for the irradiation of a region of an irradiation object in an illumination session, wherein the irradiation object is to be arranged at an object location, wherein the object location is arranged at a distance relative to a radiation output region of the radiation emitting units through which the radiation generated by the at least one electromagnetic radiation source exits the radiation emitting units during operation of the illumination device; and optionally further comprising at least one electronic control unit.

The invention relates to the technical field of preparation and application of tumor diagnosis and treatment probes, and discloses an orthogonal near-infrared light driven imaging / membrane targeted photodynamic therapy probe and a method thereof.The surfaces of rare earth down-conversion nanoparticles are modified with mesoporous silicon doped with photosensitizer pheophorbide A and perfluorocarbon through a sol-gel method; and mixing the meso-porous silicon modified down-conversion nanoparticles with distearoyl phosphatidyl ethanolamine-PEG (Polyethylene Glycol) to finally obtain the orthogonal near-infrared light driven imaging / membrane targeted photodynamic therapy probe. The prepared nano-probe can achieve orthogonal near-infrared light driven imaging and photodynamic therapy under 980 nm laser and 808 nm laser respectively, a reasonable orthogonal near-infrared light excitation system is formed, meanwhile, solution, cell and living body level experiments show that the nano-probe is good in biocompatibility and good in photodynamic therapy effect, and the application range of the nano-probe is widened. The pyroptosis can be efficiently induced through a membrane targeting photodynamic therapy, and excellent treatment performance is shown in vitro and in vivo.

The invention discloses a two-photon absorption G-quadruplex targeting metal ruthenium complex and application thereof in photodynamic therapy. A photosensitizer plays a crucial role in the photodynamic therapy; the small molecule photosensitizer shows relatively poor light stability and photobleaching property; on the other hand, the transition metal complexes have very strong stability and are not prone to photobleaching, but the absorption wavelength of the transition metal complexes is 405 nm, so that the tissue penetrability is poor, and most transition metal complexes are insoluble in water; along with the development of photodynamic therapy, a photosensitizer with good water solubility, high light stability and strong tissue penetrability needs to be developed urgently, and therefore, the ruthenium (II) complex is provided and can generate strong two-photon absorption at 750nm, so that the light damage effect is reduced, and the tissue penetrability is enhanced; in addition, the ruthenium (II) complex shows good water solubility, has specific targeting to G-quadruplex DNA, and can quickly generate a large amount of singlet oxygen.

A lighting device for photodynamic therapy, the lighting device comprising at least two electromagnetic radiation emitting units, the at least two electromagnetic radiation emitting units comprising at least one electromagnetic radiation source configured to generate radiation for irradiating an area of an irradiated object in a lighting session, the irradiation object is to be arranged at an object location, where the object location is arranged at a distance from a radiation output region of the radiation emitting unit through which radiation generated by the at least one electromagnetic radiation source exits the radiation emitting unit during operation of the lighting device.

The present disclosure provides water-soluble and low-aggregation NIR- and SWIR-active small molecule polymethine dyes with improved properties for use in optical imaging, photothermal therapy, and photodynamic therapy.

The present invention relates to a method for synthesising a photosensitive polyethylene glycol (PEG) and methyl ether-poly(d,l-lactide) (PDLLA) polymer by tosylating its organic group. The photosensitive PEG-PDLLA polymer is functionalised by opening the Lactide monomer ring by polymerising and covalently bonding with the alcohol terminal group of PEG via an esterification with the tosylated organic group. The nanopolymer obtained using the disclosed method is suitable for controlled release processes of hydrophobic and hydrophilic active ingredients with specific delivery based on photodynamic therapy. The PEG-PDLLA-based nanopolymer obtained is able to encapsulate hydrophobic and hydrophilic active ingredients, configuring a nanocarrier with amphiphilic filler with high potential for photodynamic therapy. The method in turn involves nanoprecipitation by removing the organic solvent with optimal photo response properties to UV light.

An illumination system (1) for photodynamic therapy is provided, the illumination system comprising an illumination source (2) configured to emit electromagnetic radiation (3) to illuminate a target surface (4) during operation, and an electronic control unit (5), wherein the illumination source is configured such that the intensity of the electromagnetic radiation emitted by the illumination source is variable, wherein the electronic control unit is operably connected to the illumination source and is configured to control the operation of the illumination source in accordance with an illumination protocol during an illumination session performed with the illumination system, and wherein the illumination protocol comprises instructions to operate the illumination source in a plurality of different modes during the illumination session, said modes comprising: a) a first mode, wherein in the first mode the electronic control unit controls the operation of the illumination source such that the intensity of the electromagnetic radiation emitted by the illumination source is continuously or quasi-continuously increased from a base intensity B to a target intensity T over a first mode time interval, b) a second mode, wherein in the second mode the electronic control unit controls the operation of the illumination source such that the intensity of the electromagnetic radiation emitted by the illumination source is constant or substantially constant over a second mode time interval, and c) a third mode, wherein in the third mode the electronic control unit controls the operation of the illumination source such that the illumination source is operated such that a dark phase and an illumination phase are alternated over a third mode time interval, wherein the intensity of the electromagnetic radiation emitted by the illumination source is lower in the dark phase than in the illumination phase, or wherein in the dark phase the illumination source does not emit electromagnetic radiation, while in the illumination phase the illumination source emits electromagnetic radiation. Furthermore, a computer program product and a kit for treating a disease and a method for operating an illumination source and a method for treating a skin disease are provided.

The invention belongs to the technical field of medical material preparation, and particularly relates to a photodynamic-based composite material for treating periodontitis and a preparation method and application of the photodynamic-based composite material. The method comprises the following steps: dispersing sodium dodecyl benzene sulfonate, tin chloride pentahydrate and L-cysteine into a mixed solution of water and ethylene glycol, uniformly stirring, and carrying out hydrothermal reaction to obtain nanosheets; then mixing with sulfydryl-polyethylene glycol, and carrying out ultrasonic treatment to obtain tin disulfide nanosheets; the preparation method comprises the following steps: mixing a germanium oxide solution, a chromium nitrate nonahydrate solution, zinc nitrate hexahydrate, gallium nitrate hydrate and water, stirring in a dark place, adding ammonia water, continuously stirring uniformly, and carrying out a hydrothermal reaction to obtain long-luminescent nanoparticles; and finally, dissolving the tin disulfide nanosheets and the long luminous nanoparticles in water, stirring in a dark place, adding a methylene blue solution, and continuously stirring in a dark place, thereby obtaining the long luminous nano-particles. The composite material for treating periodontitis based on photodynamic therapy prepared by the invention can effectively improve the curative effect of the photodynamic therapy in periodontitis treatment.

A ruthenium (II) coordination compound: (III) wherein n is 0 or 2 and R is selected from the group consisting of methyl; phenyl; -CH2NH2,-CH2NH2; -CH2OH,-CH2OH; -COOH,-COOH; the present invention relates to a coordination compound comprising an ester group-COOR1, an amide group-CONR2R3, which coordination compound is useful as a photosensitizer in photodynamic therapy for the treatment of tumors. In particular, the light-sensitive drug comprises a compound (III) incorporated into a liquid lipid nanoparticle-layered and / or non-layered crystal, in particular cubic liquid crystal nanoparticles. The process of obtaining the compound (III) involves three reaction steps (IV). # imgabs0 #

To provide a new rotaxane-type photosensitizer exhibiting high light stability and enabling coexistence of suitable water solubility and cell membrane permeability.SOLUTION: A photosensitizer for photodynamic therapy containing a rotaxane-type reactive oxygen species generator, wherein the rotaxane-type reactive oxygen species generator is a [3]-rotaxane formed by being included by two cyclodextrins or derivatives thereof. Also provided is the photosensitizer which is an anticancer agent.SELECTED DRAWING: None

The invention belongs to the technical field of nano biological materials, and provides a nano composite material based on a UCNPs-photosensitizer and a preparation method and application of the nano composite material based on the UCNPs-photosensitizer, and the method comprises the following steps: 1, preparing TK-DOX through an amide reaction; 2, preparing an OA-UCNPs solution by a thermal coprecipitation method; 3, removing oleic acid by a hydrochloric acid method to prepare UCNPs; and 4, preparing the UCNPs-photosensitizer / TK-DOX by a coordination loading method. The nano composite material disclosed by the invention can realize high sensitization efficiency under low-power excitation, so that singlet oxygen is generated to realize cascade drug release, and synergistic treatment of photodynamic therapy and chemotherapy is realized by utilizing an EPR effect.

A method for photographing at least a portion of a subject is disclosed, the method comprising: generating a photography scheme, the photography scheme comprising a set of photography control points, each of the photography control points comprising: a location of the platform relative to the subject; an orientation of the platform relative to the subject; and one or more photography parameters; determining a location and an orientation of the platform carrying the imaging system; navigating the platform to each of the photography control points and operating the imaging system to capture an image of the subject at each of the photography control points according to the associated photography parameters. A method of administering photodynamic therapy to a subject is also disclosed.

A light emitting device is a light emitting device for use in a photodynamic therapy. The light emitting device includes: a solid-state light-emitting element that emits primary light in which an energy density is 0.5 W / mm2 or more; and a wavelength converter including a first phosphor that emits first wavelength-converted light. The first wavelength-converted light has a light component across at least a whole of a wavelength range of 700 nm or more and less than 800 nm. Energy of fluorescence emitted from the wavelength converter is 100 mW or more. A medical device includes the light emitting device.

A photodynamic therapy and photoacoustic measurement coexistence system includes a pulsed light source configured to emit a pulsed light; a light-splitting unit, disposed on an optical path of the pulsed light, and configured to split the pulsed light into a first split light and a second split light; a reflecting unit, disposed on an optical path of the first split light, and configured to reflect the first split light into a reflected light; a first lens, disposed on an optical path of the reflected light, and configured to refract the reflected light to an irradiated surface to form a first light spot; and a second lens, disposed on an optical path of the second split light, and configured to refract the second split light to the irradiated surface to form a second light spot.

A method of exciting an organic salt in a cell is provided. The method includes contacting the cell with a composition including the organic salt, the organic salt having a photoactive ion and a counterion. The cell uptakes the organic salt, the organic salt is substantially free of a coating within the cell, and the organic salt is non-toxic to the cell in the dark. The method also includes exposing the cell to light having a first wavelength, wherein the organic salt absorbs the light having the first wavelength and the photoactive ion becomes excited.

A light irradiation device (100) for photodynamic therapy is provided with: a flexible substrate (101); and a light source unit that is disposed on the flexible substrate (101) and includes a first LED element (103a) having a peak wavelength in a range of 400-420 nm, a second LED element (103b) having a peak wavelength in a range of 500-520 nm, and a third LED element (103c) having a peak wavelength in a range of 625-645 nm.

A method for photographing at least a portion of a subject is disclosed, the method comprising: generating a photography scheme, the photography scheme comprising a set of photography control points, each of the photography control points comprising: a location of the platform relative to the subject; an orientation of the platform relative to the subject; and one or more photography parameters; determining a location and an orientation of the platform carrying the imaging system; navigating the platform to each of the photography control points and operating the imaging system to capture an image of the subject at each of the photography control points according to the associated photography parameters. A method of administering photodynamic therapy to a subject is also disclosed.