52 results about "Photo dynamic therapy" patented technology

A light source apparatus including light spectrum-converting materials that emit light primarily over large portions of the 360 nm-480 nm and the 590-860 nm spectral range is provided. This apparatus provides a cooled, high-luminance, high-efficiency light source that can provide a broader spectrum of light within these spectral ranges than has been cost-practical by using many different dominant peak emission LEDs. Up to 15% of the output radiant power may be in the spectral range 350-480 nm in one embodiment of this device, unless a specific separate source and lamp operating mode is provided for the violet and UV. Control methods for light exposure dose based on monitoring and controlling reflected or backscattered light from the illuminated surface and new heat management methods are also provided. This flexible or rigid light source may be designed into a wide range of sizes or shapes that can be adjusted to fit over or around portions of the bodies of humans or animals being treated, or mounted in such a way as to provide the special spectrum light to other materials or biological processes. This new light source can be designed to provide a cost-effective therapeutic light source for photodynamic therapy, intense pulsed light, for low light level therapy, diagnostics, medical and other biological applications as well as certain non-organic applications.

The present invention relates to a photodynamic therapy method and uses thereof for treating an individual in need thereof, comprising administering a photosensitizer to an individual and activating the photosensitizer with a chemiluminescent light source, and/or a light-emitting diode light source, wherein the light source is in dermal contact with the individual. The present invention also relates to a device for photodynamic therapy comprising a permeable reservoir, for containing a photosensitizer formulation for skin application, the device is adapted to deliver the photosensitizer to the individual. The present invention also relates to a device for photodynamic therapy, comprising a permeable reservoir for containing a photosensitizer formulation for skin application and a light source. The light source is a chemiluminescent light source or a light-emitting diode light source and the device is adapted to deliver the photosensitizer to the individual and to irradiate a part of an individual to activate the photosensitizer.

An apparatus and method to apply photo-stimulation, photo-dynamic therapy and/or ablation laser treatment to biological tissue. The apparatus includes a plurality of radiation energy sources, preferably laser beams. Additionally, the apparatus allows either a single wavelength or a combination of various wavelengths, either coincidentally or adjacently, to be utilized to achieve a desired treatment effect. Laser beams are transmitted to the treatment area by one or more fiber optic cables which terminate at an assembly structured to collimate the emitted radiation prior to application to the tissue. In addition, the apparatus includes a focal length setting mechanism which assures that a constant, fixed distance exists between the point of discharge of the laser beam and the biological tissue, thus assuring a constant energy density at the point of application. A method is presented for applying photo-stimulation, photocollagen stimulation and/or ablation laser treatment utilizing the above apparatus.

An instrument for photodynamic therapy applies treatment light from a dye laser, white light, and ultraviolet fluorescence excitation light from an LED onto a lesion and surrounding areas in a time-multiplexed manner. The reflected white light is analyzed in a spectrometer to determine a correction for the dynamic optical spectral properties of the patient's tissue. Light emitted by fluorescence from the lesion and the surrounding areas is analyzed in another spectrometer, and the results are corrected in a computer, using the correction. An optical switch has been developed for the instrument, using a bistable solenoid and a sled.

An apparatus and method to apply photo-stimulation, photo-dynamic therapy and/or ablation laser treatment to biological tissue. The apparatus includes a plurality of radiation energy sources, preferably laser beams. Additionally, the apparatus allows either a single wavelength or a combination of various wavelengths, either coincidentally or adjacently, to be utilized to achieve a desired treatment effect. Laser beams are transmitted to the treatment area by one or more fiber optic cables which terminate at an assembly structured to collimate the emitted radiation prior to application to the tissue. In addition, the apparatus includes a focal length setting mechanism which assures that a constant, fixed distance exists between the point of discharge of the laser beam and the biological tissue, thus assuring a constant energy density at the point of application. A method is presented for applying photo-stimulation, photocollagen stimulation and/or ablation laser treatment utilizing the above apparatus.

A light emitting apparatus is disclosed for medical applications including photo-dynamic-therapy (PDT), photobiostimulation (photobiomodulation), photo-sterilization, and photo-curing. The light emitting apparatus comprises a plurality of semiconductor light emitting elements, preferably light emitting diodes (LEDs) to produce a high intensity light beam, and a liquid light guide for delivering the light beam from the light source to the treatment site.

Method to apply photo-stimulation, photo-dynamic therapy and/or ablation laser treatment to biological tissue including directing radiation from at least one radiation energy source for supplying a treatment radiation; adjusting a collimator assembly for directing radiation from the at least one radiation energy source to the treatment site; collecting radiation not absorbed at the treatment site and reflecting the radiation back to the treatment site, while a contact surface of the collector is engaged with the surface of the biomass; maintaining a set distance between the adjustable collimator assembly and the contact surface; and moving a lens relative to an outlet aperture of the adjustable collimator assembly when the collector is adjusted to thereby produce a given spot size, shape or energy density of the treatment radiation emitted from the adjustable head assembly.

A cancer screening method is provided, wherein the method is characterized by administering a compound to a patient, the compound being a complex of a fluorescent marker and a radioactive marker, in a dose emitting between 5 Gy and 20 Gy radiation. Cells are then collected preferably through non-invasive or minimally invasive means. If fluorescence is observed in the exfoliated cells, tomographic scanning is conducted to further locate and/or confirm suspected malignant areas or metastatic areas. Further observation or treatment may be conducted either through fluorescence guided endoscopy, photo-dynamic therapy, and/or radiation treatment.

The invention provides a preparation method of a nano carrier for tumor photo-dynamics therapy (PDT). According to the preparation method, Fe<3+> salts are dissolved in DMF, then a photo-sensitizer (TCPP) is added to obtain particles (NMOFs); then the particles are dispersed in water under the assistance of ultrasonic waves; crosslinking agents (EDC and NHS) are added; after the reactions betweenBSA and sulfadiazine (SDs) finish completely, dialysis is performed to obtain particles (NMOFs@BSA/SDs); then the particles are dispersed in distilled water, then Mn<2+> salts are added, the pH is adjusted, and finally dialysis is performed to obtain a carrier (NMOFs@BSA/SDs@MnO2). Nano metal organic framework particles are taken as the basis and coated by protein (BSA) and sulfadiazine (SDs); finally the particles are in-situ mineralized to obtain required particles; SDs can specifically recognize carbonic anhydrase of tumors and is capable of actively targeting the oxygen-deficient parts oftumors; MnO2 generated in mineralization can catalyze the H2O2 decomposition to increase the oxygen content of tumors; and the PDT efficiency is improved.

The invention discloses a ruthenium-anthraquinone conjugate, the preparation process thereof and the application as a photo-dynamic therapy photosensitizer. The general formula of the ruthenium-anthraquinone conjugate of the invention is [Ru(L)2HAIP].(PF6)2, the general formula of the HAIP is 1,8- dihydroxy -9,10- anthraquinoneimidazole [4,5-f][1,10] phenanthroline, the general of the L is bpy or phen. The preparation process for the ruthenium-anthraquinone conjugate comprises the following procedures: 1. the synthesis of the HAIP: 1,8- dihydroxy -9,10- anthraquinone-3-aldehyde is reacted with the phenanthroline5,6-diketone to produce the HAIP; 2. Ru(L)2Cl2 is reacted with HAIP and NH4PF6 to produce the [Ru(L)2HAIP].(PF6)2. The invention takes the aloe-emodin as the raw material and the ruthenium polypyridyl complex has single chemical composition; the synthesis route is simple and the yields are higher; during the experiment, the compound shows the light suppression to the growth of cancer cells.

Photodynamic therapy (PDT) is used in the case of bone. A photosensitizing drug is administered to a mammal. A bone insertion member is secured into bone. A fiber optic cable sheath extends from within the bone insertion member and is accessible. A fiber optic cable is inserted in the fiber optic cable sheath to deliver light to the bone. A locking member is then attached to the insertion member. Non-thermal light at a specific wavelength is then delivered to activate the drug. The insertion member and the fiber optic cable sheath may remain inside the mammal for further photodynamic therapy.

A laser apparatus is provided for medical applications or procedures, which include laser surgery, photo dynamic therapy, photo bio-modulation, etc. The output wavelength of the laser matches with the absorption band of oxygen molecule to produce highly reactive singlet oxygen from air or an oxygen enriched environment. The singlet oxygen is used as a strong oxidizer to kill bacteria. The properties of the laser such as power intensity, beam divergence, spectral linewidth, etc. are optimized for effective photo treatment of biological tissue as well as for efficient singlet oxygen generation.

A polymer-surfactant nanoparticle formulation, using the anionic surfactant aerosol OT (AOT) and polysaccharide polymer alginate, is used for sustained release of water-soluble drugs. The AOT-alginate nanoparticles are suitable for encapsulating doxorubicin, verapamil and clonidine, as well as therapeutic agents effective against dermal conditions such as psoriasis. The nanoparticles are also suitable for encapsulating photo-activated compounds such as methylene blue for use in photo-dynamic therapy of cancer and other diseases, and for treating tumor cells that exhibit resistance to at least one chemotherapeutic drug.

The invention discloses a rare earth upconversion diagnosis-and-treatment-integrated nanocomposite material. The rare earth upconversion diagnosis-and-treatment-integrated nanocomposite material is acuprous oxide modified rare earth upconversion nanocomposite prepared by the following steps: using oil-soluble upconversion nanoparticles (UCNPs) as cores; and then, allowing epitaxial growth of cuprous oxide (Cu(2)O) on surfaces of the UCNPs so as to form shells, thereby obtaining the cuprous oxide modified rare earth upconversion nanocomposite grown by interface nucleation. The Cu(2)O can transfer fluorescence resonance energy with upconversion emission of the UCNPs excited by near-infrared light so as to produce sufficient active oxygen, thereby meeting needs of photodynamic therapy; and moreover, the Cu(2)O can synchronously cooperate with the oil-soluble UCNPs so as to realize integrated diagnosis and treatment. The invention further provides a preparation method of the rare earth upconversion diagnosis-and-treatment-integrated nanocomposite material. The preparation method of the rare earth upconversion diagnosis-and-treatment-integrated nanocomposite material comprises the following steps: using the oil-soluble UCNPs as cores; and then, allowing interface nucleation growth of the (Cu(2)O) on the surfaces of the UCNPs. The rare earth upconversion diagnosis-and-treatment-integrated nanocomposite material prepared by the preparation method is uniform in size, good in stability, and excellent in biocompatibility; and thus, the nanocomposite material can be used in imaging diagnosis guided photodynamic therapy so as to meet needs of clinical diagnosis and treatment integration.

The invention belongs to the technical field of medical materials, and discloses an application of a photosensitizer based on aggregation-induced emission in cell imaging and photodynamic therapy. The applicaiton is characterized in that an aggregation-induced emission compound is covalently or non-covalently introduced into a polydiacetylene supramolecular system, and is spontaneously assembled and polymerized under the hydrophilic and hydrophobic action among molecules to obtain nanoparticles. According to the invention, AIE micromolecules are covalently/non-covalently introduced into a polydiacetylene supramolecular system by utilizing the excellent performance of diacetylene in the aspect of self-assembly, and the aggregation-induced emission supramolecular polymer is spontaneously assembled under the hydrophilic and hydrophobic action among molecules. The problem of aggregation fluorescence quenching is solved, and good water solubility is achieved. In addition, polymerization of diacetylene enables the aggregate structure to be rigidified, and leakage of the fluorescent dye can be prevented, so that a novel nanostructure with a clear structure is developed. The invention discusses the application of the supramolecular luminescent nano material in cell imaging and photodynamic therapy for the first time, and realizes integration of diagnosis and treatment.

The invention discloses an all-solid-state Raman frequency multiplication dark red laser and a laser generation method. The laser includes a pumping unit, an input endoscope (4), a laser crystal (5),a polarizing film (7), a first insertion lens (8), a Raman crystal (9), a second insertion lens (10), a nonlinear optical crystal (11) and an output endoscope (12), the input endoscope (4) and the output endoscope (12) form a fundamental frequency light resonant cavity, and the first insertion lens (8) and the output endoscope (12) form a Raman light resonant cavity; the dark red laser has the advantages of being high in output power, good in light beam quality, simple in structure, stable in performance, low in cost and the like, and has important application in the fields of laser display, biophotonics, fluorescence imaging, photodynamic therapy and the like.

The present application provides an organosilica nanoparticle comprising: (a) a photosensitizer for photodynamic therapy covalently incorporated therein; and (b) optionally, at least one agent encapsulated therein, as well as a pharmaceutical composition comprising said organosilica nanoparticle. Also provided herein are said organosilica nanoparticle or pharmaceutical composition for use as a medicament or in the treatment of a disease, disorder, or condition. More specifically, provided is a method for treating a disease, disorder, or condition in a subject using said aid organosilica nanoparticle or pharmaceutical composition.

Provided are nanoparticles surface functionalized with PEG groups and having one or more photosensitizer group. The PEG groups may be functionalized. The nanoparticles may also include therapeutic groups and/or targeting groups. The nanoparticles may be made by hydrolysis of a silica precursor and, optionally, an alumina precursor, in various aqueous reaction mediums. The nanoparticles may be used in photodynamic therapy methods. The methods may also include imaging of an individual.