Rare earth upconversion diagnosis-and-treatment-integrated nanocomposite material as well as preparation method and application thereof

Abstract

The invention discloses a rare earth upconversion diagnosis-and-treatment-integrated nanocomposite material. The rare earth upconversion diagnosis-and-treatment-integrated nanocomposite material is acuprous oxide modified rare earth upconversion nanocomposite prepared by the following steps: using oil-soluble upconversion nanoparticles (UCNPs) as cores; and then, allowing epitaxial growth of cuprous oxide (Cu(2)O) on surfaces of the UCNPs so as to form shells, thereby obtaining the cuprous oxide modified rare earth upconversion nanocomposite grown by interface nucleation. The Cu(2)O can transfer fluorescence resonance energy with upconversion emission of the UCNPs excited by near-infrared light so as to produce sufficient active oxygen, thereby meeting needs of photodynamic therapy; and moreover, the Cu(2)O can synchronously cooperate with the oil-soluble UCNPs so as to realize integrated diagnosis and treatment. The invention further provides a preparation method of the rare earth upconversion diagnosis-and-treatment-integrated nanocomposite material. The preparation method of the rare earth upconversion diagnosis-and-treatment-integrated nanocomposite material comprises the following steps: using the oil-soluble UCNPs as cores; and then, allowing interface nucleation growth of the (Cu(2)O) on the surfaces of the UCNPs. The rare earth upconversion diagnosis-and-treatment-integrated nanocomposite material prepared by the preparation method is uniform in size, good in stability, and excellent in biocompatibility; and thus, the nanocomposite material can be used in imaging diagnosis guided photodynamic therapy so as to meet needs of clinical diagnosis and treatment integration.

Description

technical field [0001] The invention relates to the technical field of nanobiological materials, in particular to a rare earth up-conversion diagnosis and treatment integrated nanocomposite material, a preparation method and an application thereof. Background technique [0002] Cancer has become one of the major diseases that endanger human health. Traditional anti-cancer methods have some limitations, such as chemotherapy resistance, radiotherapy has serious side effects, and surgery has a high recurrence rate. [0003] Photodynamic therapy (PDT) is an emerging treatment method in recent years, which has the advantages of good controllability and small side effects. The principle is that the photosensitizer activates the surrounding oxygen molecules to generate active oxygen under the excitation of the light source, thereby damaging the important structure and function of the cell, and finally achieves the purpose of destroying the diseased tissue. [0004] Photodynamic th...

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Problems solved by technology

[0006] However, in the prior art, due to the limitations of the preparation process and the performance of material components, few photosensitizers can be directly excited by NIR light to generate enough reactive oxygen species ROS, so it cannot meet the requirements of PDT with a unique structure and is not easy to degrade photosensitizers to generate enough cytotoxic reactive oxygen species ROS to achieve the desired therapeutic effect

At the same time, there is currently no nanocomposite material that meets the needs of PDT and has the function of fluorescence imaging for the diagnosis of cancer diseases, combining the treatment together, so as to have the integrated function of diagnosis and treatment.

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