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Antibacterial healing-promoting wound dressing and preparation method thereof

A wound and extract technology, which is applied in medical formula, medical science, drug delivery, etc., can solve the problems of single antibacterial agent, large amount of antibacterial agent, and shorten wound healing time, so as to achieve convenient use and satisfy wound disinfection and protection, the effect of using a small dose

Active Publication Date: 2020-10-09
HARBIN QIANBAINA BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The purpose of the present invention is to provide an antibacterial and healing-promoting wound dressing and a preparation method thereof, which can form an isolated bacterial film on the surface of the wound, which can not only inhibit bacteria and stop bleeding, and can be used well, but also can reduce wound healing time and solve the problem of existing dressing antibacterial agents. Single use, excessive use of antibacterial agent, weak antibacterial performance and inability to promote wound healing, etc.

Method used

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  • Antibacterial healing-promoting wound dressing and preparation method thereof
  • Antibacterial healing-promoting wound dressing and preparation method thereof
  • Antibacterial healing-promoting wound dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] An antibacterial wound dressing for promoting healing, made of the following components in mass percentage: octenidine 0.1%, clove extract 0.1%, coptis chinensis extract 0.25%, scutellaria baicalensis extract 0.15%, polyethylene glycol 4003%, Tween 80 3%, Polyvinyl Alcohol 17883%, Carbomer 9400.1%, Cetostearyl Octanoate 1%, Stearyl Octanoate 3%, Disodium EDTA 0.001%, Menthol 0.1%, The balance is purified water.

[0068] In the present embodiment, the clove extract is extracted according to the following steps:

[0069] (1) Take clove crude drug, crush it until it passes through a 20-mesh sieve, add 60% ethanol equivalent to 15 times the weight of clove, soak for 12 hours, heat and reflux for 2 hours, and obtain medicinal residue 1 and filtrate 1;

[0070] (2) Add 15 times of 50-75% ethanol to the obtained medicinal residue 1, heat and reflux for 2 hours, filter to obtain medicinal residue 2 and filtrate 2, combine filtrate 1 and filtrate 2, and recycle ethanol by disti...

Embodiment 2

[0089] An antibacterial wound dressing for promoting healing, made of the following components: Octenidine 0.001%, Clove Extract 0.5%, Coptis Rhizoma Extract 1%, Scutellaria Baicalensis Extract 0.7%, Polyethylene Glycol 400 2.63%, Polyethylene Glycol 400 Sorbitate 80 0.001%, Polyvinyl Alcohol 0588 0.001%, Carbomer 940 0.877%, Cetostearyl Caprylate 2.63%, Stearyl Octanoate 2.63%, Disodium EDTA 0.001%, Menthol 0.1 %, sodium hydroxide 0.088, and the balance is purified water.

[0090] The preparation process of clove extract, Coptis chinensis extract and Scutellaria baicalensis extract in this example is the same as that in Example 1.

[0091] The preparation process of the wound dressing described in this example is the same as that in Example 1.

Embodiment 3

[0093]An antibacterial wound dressing for promoting healing, made of the following components: Octenidine 0.1%, Clove Extract 0.05%, Coptis Rhizoma Extract 0.1%, Scutellaria Baicalensis Extract 0.07%, Polyethylene Glycol 400 3%, Polyethylene Glycol 400 Sorbitate 80 3%, Polyvinyl Alcohol 0588 3%, Carbomer 940 0.001%, Cetearyl Octanoate 0.001%, Stearyl Octanoate 0.001%, Disodium EDTA 0.001%, Menthol 0.1 %, the balance is purified water.

[0094] The preparation process of clove extract, Coptis chinensis extract and Scutellaria baicalensis extract in this example is the same as that in Example 1.

[0095] The preparation process of the wound protection film described in this example is the same as that in Example 1.

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Abstract

The invention discloses an antibacterial healing-promoting wound dressing and a preparation method thereof, and relates to the technical field of medical dressings. The antibacterial healing-promotingwound dressing comprises an effective substance and a wound dressing matrix, wherein the effective substances comprise 0.001-0.5% of otinidine and 0.1-5% of a traditional Chinese medicine extract, and the wound dressing matrix comprises 0.5-8% of a thickening agent, 0.1-10% of an emulsifying agent, 0.002-20% of an oil phase, 0.001-1% of a chelating agent and the balance of water. The antibacterial healing-promoting wound dressing disclosed by the invention is small in dosage, and obvious in effects of inhibiting the growth of wound bacteria and preventing infection; the wound dressing is goodin film-forming property and thin in formed film; the wound dressing is convenient to spray and smear, and meanwhile, the functions of wound disinfection and protection are achieved; no pricking feeling of an organic solvent is caused, the mildness is realized, and the compliance is good.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to an antibacterial wound dressing for promoting healing and a preparation method thereof. Background technique [0002] Wound refers to the damage of human tissues or organs caused by physical, chemical and other factors. Its healing is a dynamic and complex process, including coagulation phase, inflammation phase, cell proliferation phase and new tissue remodeling phase. The speed of wound healing is affected by factors such as wound type, pathological conditions, and dressing type. As a temporary skin substitute, dressing can protect the wound, stop bleeding, prevent infection, and more importantly, promote wound healing. [0003] Traditional dressings such as gauze and cotton pads are the main dressings used clinically. However, the hemostatic effect of traditional dressings is unsatisfactory, and there is no moisturizing effect. The granulation tissue is easy to ente...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0019A61L26/0023A61L26/0057A61L26/0061A61L26/0066A61L2300/204A61L2300/30A61L2300/404A61L2300/45A61L2400/04C08L71/02C08L29/04C08L33/02C08L5/04C08L39/06C08L5/00C08L83/04
Inventor 高纳新霍东风
Owner HARBIN QIANBAINA BIOPHARM
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