Method for separating and purifying cannabinol from industrial hemp

A technology for separation and purification of industrial hemp, applied in the field of chemistry, to achieve the effect of solving the problem of separation and purification, low cost and simple operation

Pending Publication Date: 2020-10-13
云南古润生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a method for sep

Method used

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  • Method for separating and purifying cannabinol from industrial hemp

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Embodiment 1

[0031] A method for separating and purifying cannabinol from industrial hemp, the steps are as follows:

[0032] A. Prepare industrial hemp flower 1, extract industrial hemp extract 2 by alcohol method, use water sinking method for industrial hemp extract 2 to obtain cannabinol crude product 3 with a content of 15%-35%, weigh 100g of cannabinol crude product 3;

[0033] B. Add ethanol solution 4 to the crude cannabinol 3 and stir to obtain the crude ethanol solution 5. The ratio of the crude cannabinol 3 to the ethanol solution 4 is 1g: 5-10ml, so according to the quality of the crude cannabinol 3, Configure 500ml of ethanol solution 4;

[0034] C, the crude ethanol solution 5 is evenly added to the column of the activated macroporous resin 6, and the sample load is 1%; the model of the macroporous resin 6 is D201;

[0035] D, macroporous resin 6 is carried out normal pressure elution with the first ethanol solution 7 of 40% to obtain the first eluent 8 and elute macroporous...

Embodiment 2

[0040] A method for separating and purifying cannabinol from industrial hemp, the steps are as follows:

[0041] A. Prepare industrial hemp flower 1, use supercritical method to extract industrial hemp extract 2, obtain the crude product 3 of cannabinol with a content of 15%-35% for the method of molecular distillation of the industrial hemp extract 2, and weigh 150g of crude cannabinol 3;

[0042] B. Add ethanol solution 4 to the crude cannabinol 3 and stir to obtain the crude ethanol solution 5. The ratio of the crude cannabinol 3 to the ethanol solution 4 is 1g: 5-10ml, so according to the quality of the crude cannabinol 3, Configure 900ml of ethanol solution 4 to get final product;

[0043] C, the crude ethanol solution 5 is evenly added to the column of the activated macroporous resin 6, and the sample load is 3%; the model of the macroporous resin 6 is D201;

[0044] D, macroporous resin 6 is carried out normal pressure elution with the first ethanol solution 7 of 55% ...

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Abstract

The invention relates to a method for separating and purifying cannabinol from industrial hemp, and belongs to the technical field of chemistry. The method includes following steps: adding an ethanolsolution into the cannabinol crude product and stirring the solution to obtain a crude product ethanol solution; uniformly adding the crude ethanol solution into the activated macroporous resin column; carrying out normal-pressure elution on the macroporous resin by using a first ethanol solution to obtain a first eluent and first-time eluted macroporous resin; and performing normal-pressure elution on the macroporous resin subjected to primary elution by using a second ethanol solution to obtain a second eluent, adding a third ethanol solution into the second concentrated solution to obtain aconcentrated ethanol solution, and filtering and drying crystals to obtain cannabinol, of which the content is greater than or equal to 95%. The method has the beneficial effects that the high-puritycannabinol is obtained by separating the cannabinol according to the huge difference between the peak appearance time of the cannabinol in the reversed-phase column and other cannabinoid substances and then crystallizing the cannabinol; the method is simple to operate, low in cost and suitable for industrial production, and the problem of separation and purification of the cannabinol is solved.

Description

Technical field: [0001] The invention relates to a method for separating and purifying cannabinol from industrial hemp, belonging to the technical field of chemistry. Background technique: [0002] Industrial hemp refers to hemp that is legally grown and has a tetrahydrocannabinol content of less than 0.3%. In China, industrial hemp is called hemp, which is an annual herbaceous plant belonging to the genus Cannabis of the family Cannabinaceae. It has a wide range of applications, including textiles, papermaking, food, medicine, hygiene, daily chemicals, leather, automobiles, construction, decoration, packaging and other fields. It is a classic means of production. [0003] Cannabis leaves contain a variety of cannabinol derivatives, which have been separated into more than 15 kinds, the more important ones are: cannabinol, cannabidiol, tetrahydrocannabinol, cannabinolic acid, cannabidiolic acid, tetrahydrocannabinolic acid . [0004] Cannabidiol is referred to as CBN for ...

Claims

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Application Information

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IPC IPC(8): C07D311/80
CPCC07D311/80Y02P20/54
Inventor 曹建锋李卫星陈梦达
Owner 云南古润生物科技有限责任公司
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