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A kind of bifunctional fluorescent probe molecule, preparation and application
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A fluorescent probe and molecular technology, applied in the field of fluorescent probes, can solve the problems of inability to identify, identify, and use masking agents at the same time, and achieve the effect of good specificity and high sensitivity
Active Publication Date: 2021-10-15
BEIJING INSTITUTE OF TECHNOLOGYGY
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Problems solved by technology
However, most either could not be discriminated in the same measurement method, or could not be discriminated simultaneously with a masking agent
Method used
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Embodiment 1
[0029] A fluorescent probe, its structural formula is as follows:
[0030]
[0031] A kind of preparation method of fluorescent probe, concrete steps are as follows:
[0032] Step 1: Dissolve 0.62g of 1,3,5-trioxane in 50ml of glacial acetic acid, and add 3ml of salicylaldehyde dropwise while stirring to obtain mixed solution A;
[0033] Step 2: Add 3 drops of catalyst concentrated sulfuric acid to the mixed solution A; obtain solution B after the reaction is complete;
[0034] Step 3: After cooling the solution B, pour it into a beaker placed in crushed ice in a thin stream, wash the solid matter with alcohol, and then dry it to obtain a solid;
[0035] Step 4: Dissolve 0.50g of the solid obtained in Step 3 and 21.82g of 4,4'-diaminodiphenylsulfone in 20ml of DMF solution; add 3 drops of catalyst concentrated hydrochloric acid dropwise at 24°C; after the reaction is complete, cool to room temperature ; in DMSO / H 2 O solution, the product was filtered, dried, and recryst...
Embodiment 2
[0047] A fluorescent probe, its structural formula is as follows:
[0048]
[0049] A kind of preparation method of fluorescent probe, concrete steps are as follows:
[0050] Step 1: Dissolve 0.90g of 1,3,5-trioxane in 50ml of glacial acetic acid, and add 5ml of salicylaldehyde dropwise while stirring to obtain mixed solution A;
[0051] Step 2: Add 5 drops of catalyst concentrated sulfuric acid to the mixed solution A; obtain solution B after the reaction is complete;
[0052] Step 3: After cooling the solution B, pour it into a beaker placed in crushed ice in a thin stream, wash the solid matter with alcohol, and then dry it to obtain a solid;
[0053] Step 4: Dissolve 0.75 of the solid obtained in Step 3 and 22.32g of 4,4'-diaminodiphenylsulfone in 20ml of DMF solution; at 35°C, add 5 drops of catalyst concentrated hydrochloric acid; after the reaction is complete, cool to room temperature ; The product was filtered, dried and recrystallized with DMF solution. Get flu...
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Abstract
The invention relates to a preparation method of a fluoride ion and cyanide detection probe, which belongs to the technical field of fluorescent probes. The present invention reacts 1,3,5-trioxane and glacial acetic acid, and it is used DMSO / H 2 O recrystallization; reacting 4,4'-diaminodiphenyl sulfone with the previously obtained compound to prepare a bifunctional fluorescent molecular probe; filtering and washing the product and drying and weighing to obtain the final product. The probe realizes the detection of F in both UV and fluorescence channels ‑ and CN ‑ Simultaneously fast and selective recognition, especially in the fluorescent channel, adding F ‑ and CN ‑ In the future, not only the fluorescence intensity of the probe molecule will be quenched to different degrees, but also the emission peak will be red-shifted to different degrees, which is very important for the differential detection of F ‑ and CN ‑ Very effective.
Description
technical field [0001] The invention relates to a bifunctional fluorescent probe molecule, its preparation and application, in particular to a method for detecting F - and CN - A fluorescent probe belongs to the technical field of fluorescent probes. Background technique [0002] The design and synthesis of single-molecule optical sensors, which selectively detect multiple anions through changes in solution color and spectral response, have been extensively studied due to their important roles in biological and chemical processes as well as academic challenges. Among all anions, especially cyanide and fluoride, play important roles in daily life, biochemical behavior and a wide range of industrial products. Cyanide is released into the environment mainly through the gold and silver mining process, but is a very toxic anion in biology and the environment, causing poisoning. At the same time, fluoride is a biologically vital anion due to its established role in the treatmen...
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