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Systems and methods for priming fluid circuits of plasma processing system

A plasma processing and circuit technology, applied in the system field, can solve problems such as removal

Pending Publication Date: 2020-10-30
HDL THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It may be difficult to remove a sufficient amount of solvent from the defatted plasma to safely return the defatted plasma to the patient

Method used

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  • Systems and methods for priming fluid circuits of plasma processing system
  • Systems and methods for priming fluid circuits of plasma processing system
  • Systems and methods for priming fluid circuits of plasma processing system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0201] Example 1: Use about 10 milliliters (ml) of human plasma. The plasma was mixed with n-butanol / DiPE solvent. Use a solvent to plasma ratio of 2:1. A shaker is used to perform the mixing operation, which lasts about five minutes. A centrifugal force of 563 times G was applied for about two minutes to separate the delipidated plasma from the solvent. The effect of varying the percentage of n-butanol in the solvent over a range of 0% to 40% was that the remaining lipids gradually decreased as the amount of n-butanol in the solvent increased.

Embodiment 2

[0202] Example 2: In another similar experiment, 10 ml of bovine plasma was mixed with n-butanol / DiPE solvent containing 25% n-butanol. The mixture was mixed using a shaker for about 5 minutes. A centrifugal force of 563 times G was applied for about two minutes to separate the delipidated plasma from the solvent. The effect of varying the solvent to plasma ratio in the range of 0.25 to 10 was that lower ratios, especially in the range of 1 to 2, resulted in the greatest reduction in lipid concentration in the delipidated solution.

Embodiment 3

[0203] Example 3: In another similar experiment, 10 ml of human plasma was mixed with n-butanol / DiPE solvent containing 25% n-butanol using a solvent to plasma ratio of 2:1. Mix the different mixture samples using a shaker and vortex. Gravity separation was used for about 5 minutes to separate some of the samples, and a centrifugal force of 563 times G was applied for about two minutes to separate the delipidated plasma from the solvent of the remaining samples. The effect of the different mixing methods and by varying the duration of mixing for the two methods used for separation (gravity and centrifugation) was that there was a variation in the lipid concentration remaining in the delipidated plasma.

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PUM

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Abstract

Methods of priming a plasma processing system are disclosed. The plasma processing system has a number of different fluid flow circuits that are defined by sources of fluid, fluid flow paths, waste containers, a mixer, a separator, valves and a pump. A first fluid circuit is flushed, where the first fluid circuit is defined by a source of a first fluid, a first valve positioned between the sourceof the first fluid and the first fluid flow path, a second valve positioned between the first fluid flow path and the second fluid flow path, a first pump positioned between the second fluid flow pathand the third fluid flow path, and a first waste container in fluid communication with the third fluid flow path. A second fluid circuit is then flushed by closing and opening certain valves.

Description

[0001] cross reference [0002] This application is based upon U.S. Provisional Patent Application No. 62 / 589,919, filed November 22, 2017, entitled "Systems and Methods for Causing Regression of Arterial Plaque." technical field [0003] The present invention generally relates to systems, devices and methods for the regression of vulnerable arterial plaques by removing lipids from HDL white particles while leaving LDL particles substantially intact by ex vivo treatment of plasma using a single solvent or multiple solvents , such plaques are associated with many disease states. More specifically, the presently disclosed invention addresses the priming of plasma processing systems and the management of waste (particularly solvent waste) generated by the processing. Background technique [0004] Familial hypercholesterolemia (FH) is an inherited autosomal dominant disorder characterized by markedly elevated low-density lipoprotein (LDL), tendinous xanthomas, and premature cor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/078
CPCA61M1/0281A61M1/3643A61M1/38A61M2202/046A61M2202/0458A61M1/0218A61M1/3486A61M1/3616A61M2202/0415A61K31/575A61K35/16A61M1/0209B01D11/0446B01D11/0492B01D15/10
Inventor H.B.布雷沃M.M.马丁T.珀尔曼
Owner HDL THERAPEUTICS