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Probiotic buccal tablet for preventing oral diseases and preparation method thereof

A technology of oral diseases and probiotics, which is applied in the field of probiotic lozenges and its preparation for the prevention of oral diseases. Oral micro-ecological balance, improvement of oral micro-ecology, and the effect of improving taste

Active Publication Date: 2022-04-19
HUNAN KANG QI YI BAI BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the presence of probiotics in probiotic buccal tablets is not only susceptible to contamination, but also stays in the oral cavity for a short time, unable to effectively kill harmful bacteria residing on the biofilm, and the effect of preventing oral diseases is poor, which needs to be solved urgently

Method used

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  • Probiotic buccal tablet for preventing oral diseases and preparation method thereof
  • Probiotic buccal tablet for preventing oral diseases and preparation method thereof
  • Probiotic buccal tablet for preventing oral diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The filtering device includes a casing, a bidirectional electric push rod 12, two sets of delivery pipelines and a filtering mechanism.

[0041] The housing includes a cover plate 1 and two end plates 4 respectively fixed on the two ends of the cover plate 1. The opposite sides of the cover plate 1 are provided with through holes 13 along its length direction. Open the drain hole.

[0042] The two-way electric push rod 12 is fixed on the outer surface of the cover plate 1, and the two telescopic ends of the two-way electric push rod 12 are respectively connected with two sets of conveying pipelines.

[0043] The conveying pipeline is located between the two end plates 4 and communicates with the liquid guide holes on the end plates 4 respectively. The conveying pipeline includes movable pipes 2 and telescopic pipes 19 connected in series, wherein the telescopic pipe 19 One end is fixed on the inner side of the end plate 4 and communicates with the liquid guide hole. Th...

Embodiment 2

[0054] A probiotic lozenge for preventing oral diseases, the raw materials of which include: 1kg of probiotic compound, 100kg of filler, 2kg of pectin, 1kg of gelatin, 1kg of magnesium stearate, and 1kg of water-soluble porogen;

[0055] The filler is composed of cornstarch, lactose powder and dextrin in a mass ratio of 10:4:1.

[0056] During the preparation of the probiotic complex, mix 5kg selenized chitosan, 1kg sodium alginate, and 20kg water evenly, sterilize at 110°C, add 0.2kg bifidobacterium and stir evenly, the stirring temperature is 10°C, and the stirring speed is 60r / min, freeze-dried at -20°C to obtain the probiotic complex.

[0057] The water-soluble porogen is prepared by the following process: mix 10kg sodium chloride, 1kg polyethylene glycol, and 5kg sucrose evenly, stir at 150°C until the sucrose dissolves, continue stirring for 8 minutes at a stirring speed of 100r / min, and pour it into The product was further pelletized in the filtration device described...

Embodiment 3

[0062] A probiotic lozenge for preventing oral diseases, the raw materials of which include: 2kg of probiotic compound, 100kg of filler, 1kg of pectin, 2kg of gelatin, 0.2kg of magnesium stearate, and 2kg of water-soluble porogen;

[0063] The filler is composed of cornstarch, lactose powder and dextrin in a mass ratio of 10:2:2.

[0064] During the preparation of the probiotic complex, mix 2kg selenized chitosan, 2kg sodium alginate, and 10kg water evenly, sterilize at 120°C, add 0.12kg lactic acid bacteria and stir evenly, the stirring temperature is 18°C, and the stirring speed is 40r / min , -28 ℃ freeze-dried to obtain the probiotic complex.

[0065] The water-soluble porogen is prepared by the following process: mix 5kg sodium chloride, 2kg polyethylene glycol, and 2kg sucrose evenly, stir at 160°C until the sucrose dissolves, continue stirring for 4 minutes at a stirring speed of 150r / min, and pour it into such The product was further pelletized in the filtration device ...

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Abstract

The invention discloses a probiotic buccal tablet for preventing oral diseases. The raw materials thereof include by weight: 1-2 probiotic complexes, 100 fillers, 1-2 pectin, 1-2 gelatin, and 0.2 magnesium stearate ‑1, porogen 1‑2; the filler consists of cornstarch, lactose powder, and dextrin in a mass ratio of 10:2‑4:1‑2. During the preparation process of the probiotic compound, the selenized chitosan, sodium alginate, and water are uniformly mixed, sterilized, added with probiotics, stirred evenly, and freeze-dried to obtain the probiotic compound. The invention discloses a preparation method of the probiotic buccal tablet for preventing oral diseases, which comprises: uniformly mixing fillers and magnesium stearate, and sterilizing to obtain a prefabricated material; adding pectin, gelatin, porogen agent, probiotic compound, continue to stir, and dry to obtain compressed material; the compressed material is crushed and sieved by a powder preparation device, and then sent into a mold to be compressed into tablets to obtain probiotic lozenges for preventing oral diseases.

Description

technical field [0001] The invention relates to the technical field of probiotic buccal tablets, in particular to a probiotic buccal tablet for preventing oral diseases and a preparation method thereof. Background technique [0002] Buccal tablet refers to a tablet form that dissolves slowly in the oral cavity. It can produce long-lasting drug effects on the oral cavity and pharynx when used in medicine. Halitosis is a common oral disease in clinical practice. The causes of halitosis can be roughly divided into oral local factors and systemic factors, among which oral local factors account for more than 80% of the entire population, and among oral local factors, oral microecological imbalance is one of the causes of halitosis. Specifically, the food residue in the oral cavity is attached to the back of the tongue, and the microorganisms in the oral cavity decompose the protein, blood and mucin in the food residue. If the oral microecology is normal, the decomposition product...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/745A61K9/22A61K47/02A61K47/10A61K47/26A61K47/36A61P1/02A61P31/04B01D29/01B01D29/50B01D29/96A61K35/744
CPCA61K35/745A61K35/744A61K9/0056A61K9/2009A61K9/2031A61K9/2018A61K9/205A61K9/2095A61P1/02A61P31/04B01D29/01B01D29/50B01D29/96A61K2300/00
Inventor 刘赛胡冬刘从辉宋卫平李泳伸
Owner HUNAN KANG QI YI BAI BIOLOGICAL TECH CO LTD