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A kind of testing method of colloidal particle microfluidic shear force

A technology of colloidal particles and shear force, which is applied in the direction of applying stable shear force to test the strength of materials, measuring devices, instruments, etc., to achieve reliable and high-precision results

Active Publication Date: 2022-06-07
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in terms of colloidal particle microfluidic shear force testing, there is no reference

Method used

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  • A kind of testing method of colloidal particle microfluidic shear force
  • A kind of testing method of colloidal particle microfluidic shear force
  • A kind of testing method of colloidal particle microfluidic shear force

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A fluid flow rate calibration method for loading the microfluidic shear force of colloidal particles in a fluid environment, the specific steps are as follows:

[0035] 1. Insert the prepared colloidal particle suspension into Channel 1 in the flow cell and the background fluid into Channel 2. Among them, the colloidal particles are polystyrene microspheres with a diameter of 4.38 μm, and the background fluid is ultrapure water. Instrument model: Lumicks super-resolution single molecule dynamic analyzer - C-Trap.

[0036] 2. Capture colloidal microspheres with optical tweezers and keep them stationary.

[0037]3. Flow rate calibration. (1) Set the power of the electrostatic displacement table to 100%, and obtain a graph of the relationship between the shear force and time of the colloidal particles under the maximum power and maximum translational speed ( Figure 1 )； (2) When the relationship between the shear force and the time of the colloidal particles is stable in the g...

Embodiment 2

[0040] A test method for microfluidic shear force of colloidal particles in ultrapure water environment, the specific steps are as follows:

[0041] 1. The prepared colloidal particle suspension is fed into Channel 1 in the flow cell, and the background fluid that needs to be detected is fed into Channel 2. Among them, the colloidal particles are polystyrene microspheres with a diameter of 4.38 μm, and the background fluid is ultrapure water. Instrument model: Lumicks super-resolution single molecule dynamic analyzer - C-Trap.

[0042] 2. Capture colloidal microspheres with optical tweezers and keep them stationary.

[0043] 3. Flow rate calibration. (1) Set the power of the electrodynamic displacement table to 100%, and obtain a graph of the relationship between shear force and time of colloidal particles under maximum power and maximum translational speed; (2) When the relationship between the shear force and the time of the colloidal particles is stable in the graph, the fluid ...

Embodiment 3

[0048] A test method for microfluidic shear force of colloidal particles in a saline solution environment, the specific steps are as follows:

[0049] 1. The prepared colloidal particle suspension is fed into channel 1 in the flow cell, and the background fluid that needs to be detected is fed into channel 3. Among them, the colloidal particles are polystyrene microspheres with a diameter of 4.38 μm, and the background fluid is 100 mM KCl solution. Instrument model: Lumicks super-resolution single molecule dynamic analyzer - C-Trap.

[0050] 2. Capture colloidal microspheres with optical tweezers and keep them stationary.

[0051] 3. Flow rate calibration. (1) Set the power of the electrodynamic displacement table to 100%, and obtain a graph of the relationship between shear force and time of colloidal particles under maximum power and maximum translational speed; (2) When the relationship between the shear force and the time of the colloidal particles is stable in the graph, the ...

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Abstract

The invention discloses a method for testing colloidal particle microfluidic shear force. The colloidal particle suspension is connected to a channel in a flow cell, and the background fluid to be detected is connected to another channel; colloidal microspheres are captured by optical tweezers , and keep it in a static state; control the translational movement of the high-precision electric stage at the maximum power to make the fluid in the flow cell flow, and obtain the relationship between power and fluid flow rate; switch the captured colloidal microspheres to the flow cell required In the channel of the experimental fluid environment, the moving speed required for the experiment is controlled by the electric displacement stage, and the shear force of the colloidal particles is tested at different fluid flow rates; the data is collected, and the mechanical detection system of the instrument converts the obtained optical trap signal into the force of the colloidal particle. microfluidic shear force. The invention can test the shearing force of colloidal pollutants under different fluid environments, and meets the testing requirements of colloidal particle microfluidic shearing force in the fields of environmental pollution and the like.

Description

Technical field [0001] The present invention belongs to the field of colloidal chemistry technology, more particularly relates to a colloidal particle microfluidic shear force test method. Background [0002] There are many ways to load fluid shear force, such as flow chamber loading technology, microfluidic control technology, etc. These techniques power the fluid shear rate through the pressure difference created between the inlet and outlet, subjecting the particles in the sample cell to uniform or periodic shear forces; In the study of environmental microinterface processes, colloidal particles in the aquatic environment migrate or remain in porous media due to various gravitational and repulsive forces, and there are still many colloidal migration phenomena that cannot be explained by existing theories. Shear force is one of the important forces of colloidal particles in the fluid environment, and the test of microfluidic shear force of colloidal particles can help us better...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N3/24G01N3/02
CPCG01N3/24G01N3/02
Inventor 赵伟高田一梅赵鹏崔丽敏
Owner TIANJIN UNIV
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