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Application of PRPF6 to treatment of prostatecancer and castration-resistant prostate cancer

A technology of prostate cancer and castration resistance, applied in the field of biomedicine

Active Publication Date: 2020-12-08
中国医科大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the role of PRPF6 in prostate cancer has not been reported so far. Therefore, it is of great significance to study the mechanism and biological function of PRPF6 as a co-regulator in prostate cancer and castration-resistant prostate cancer.

Method used

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  • Application of PRPF6 to treatment of prostatecancer and castration-resistant prostate cancer
  • Application of PRPF6 to treatment of prostatecancer and castration-resistant prostate cancer
  • Application of PRPF6 to treatment of prostatecancer and castration-resistant prostate cancer

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Embodiment Construction

[0030] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. The experimental method that does not indicate specific condition in the embodiment, usually according to conventional conditions, such as the conditions described in textbooks and experimental guides, or according to the conditions suggested by the manufacturer, is well known or easy to know by those of ordinary skill in the art, the following implementation Examples are only preferred embodiments of the present invention, and do not limit the present invention. For those skilled in the art, the present invention can have various modifications and changes, and within the spirit and principles of the present invention, any modifications made , equivalent replacements, improvements, etc., should all be included within the protection scope of the present invention.

[0031] Example.

[0032] 1. Preparation of inhibitors.

[0033] According to PR...

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Abstract

The invention belongs to the technical field of biological medicines, relates to an application of PRPF6 to treatment of prostatecancer and castration-resistant prostate cancer, and provides an application of a PRPF6 targeting inhibitor to preparation of drugs and medical compositions for preventing or treating prostate cancer and castration-resistant prostate cancer. It is found for the first time that PRPF6 can promote the progress of the prostate cancer and the castration resistance to prostate cancer, the PRPF6 is higher in expression in prostate cancer tissue with higher grade malignancy,and inhibition of the PRPF6 has the effect of obviously inhibiting occurrence and development of prostate cancer and castration-resistant prostate cancer. The invention relates to application of thePRPF6 to treatment and resisting of the prostatecancer and the castration-resistant prostate cancer. It is found that the PRPF6 has a potential drug resistance function in the prostatecancer and castration-resistant prostate cancer endocrine drugs, a PRPF6 micromolecule inhibitor and siRNA are prepared, or it is found that PRPF6 transcription is inhibited to generate miRNA so as to treat clinicalprostatecancer and castration-resistant prostate cancer. The invention provides a new thought and new target point for treating prostaticcancer and castration-resistant prostatic cancer.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to the application of PRPF6 in the treatment of prostate cancer and castration-resistant prostate cancer. Background technique [0002] Prostate cancer (PCa) is a malignant tumor that occurs in male prostate tissue. In western countries, its mortality rate ranks second among various cancers, and its incidence rate in China is also on the rise in recent years. Androgen deprivation therapy is an important early treatment for prostate cancer, which can usually inhibit tumor progression, but after a period of treatment, some patients will develop castration-resistant prostate cancer (CRPC). After the transformation of prostate cancer into castration-resistant prostate cancer, androgen deprivation therapy will lose its effectiveness, and the possibility of tumor metastasis will increase significantly. However, there is still a lack of effective strategies and means to combat castrati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/713A61P35/00
CPCA61K31/713A61P35/00
Inventor 赵越王春玉刘伟林琳王胜利邹仁龙孙洪邈曾凯
Owner 中国医科大学
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