miRNA related to colorectal cancer and application thereof

Abstract

The invention belongs to the field of nucleic acid diagnosis and treatment, and particularly relates to miRNA related to colorectal cancer and application thereof. The miRNA related to colorectal cancer is miR-1290. The invention provides application of the miR-1290 in preparing a kit for distinguishing a colorectal cancer sample and a rectal cancer sample from a normal sample in a blood sample ofa subject. The invention determines that the miR-1290 is a miRNA diagnostic marker related to colorectal cancer for the first time, and establishes a novel colorectal cancer and rectal cancer tumor progression detection index. On the basis, the invention provides novel application of the miR-1290 in the aspect of initial diagnosis and rapid detection of colorectal cancer and rectal cancer and a related universal applicable kit.

Description

technical field

[0001] The invention belongs to the field of nucleic acid diagnosis and treatment, and in particular relates to a miRNA related to colon cancer and rectal cancer and its application. Background technique

[0002] Colon cancer and rectal cancer are one of the most common malignant tumors that seriously endanger people's health. They rank first in cancer incidence and second in mortality in developed countries, and fourth in cancer mortality in my country, and the incidence is increasing year by year. In Guangzhou, the crude incidence and mortality rates of colon cancer and rectal cancer were 9.6 / 100,000 and 5.0 / 100,000, respectively, and increased by nearly 5%. The survival and prognosis of patients depend on the detection time of the tumor. Early detection and early treatment are the only ways to improve the long-term survival rate of colon cancer and rectal cancer. For example, according to Dukes staging, the 5-year survival rate can reach 90±% in stage A ,...