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A kind of Acanthopanax senticosus extract composition, extraction method and injection thereof

A technology for extracts and compositions of Acanthopanax senticosus, which is applied in the field of extracts and compositions of Acanthopanax senticosus, can solve the problems of long extraction period, many steps, complicated processes, etc., and achieves reduction of brain edema, fewer process steps, and simple purification technology. Effect

Active Publication Date: 2022-04-12
HARBIN ZHENBAO PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is to extract eleutherosides and polysaccharides separately, which has many steps, complicated process and long extraction period.

Method used

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  • A kind of Acanthopanax senticosus extract composition, extraction method and injection thereof
  • A kind of Acanthopanax senticosus extract composition, extraction method and injection thereof
  • A kind of Acanthopanax senticosus extract composition, extraction method and injection thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of Acanthopanax extract composition:

[0027] (1) crushing: the roots and stems of Acanthopanax senticosus are crushed to make crushed material;

[0028] (2) Add 5 kg of Acanthopanax senticosus crushed material, add 12 times the amount of water to reflux extract three times, each time for 1 hour, filter, combine the filtrate, and concentrate under reduced pressure at 60 ° C to a concentrated paste with a relative density of 1.10;

[0029] (3) Add ethanol until the alcohol content reaches 85%, let it stand for 12 hours, filter and collect the filtrate, recover the ethanol under reduced pressure, and obtain the alcohol precipitated paste;

[0030] (4) Adjust the pH value of the alcohol precipitation paste to 5.0, and use a macroporous resin column for adsorption. The flow rate of the upper liquid is 2BV / h for adsorption, and the tail liquid is collected, and then eluted with 60% ethanol. The amount of eluent is 2BV. The flow rate is 1.5BV / h, and the eluate is...

Embodiment 2

[0034] Preparation of Acanthopanax extract composition:

[0035] (1) crushing: the roots and stems of Acanthopanax senticosus are crushed to make crushed material;

[0036] (2) Add 5 kg of Acanthopanax senticosus powder into 11 times the amount of water to reflux and extract three times, each time for 1.5 hours, filter, combine the filtrates, and concentrate under reduced pressure at 60 ° C to a concentrated paste with a relative density of 1.10;

[0037] (3) Add ethanol until the alcohol content reaches 85%, let it stand for 12 hours, filter and collect the filtrate, recover the ethanol under reduced pressure, and obtain the alcohol precipitated paste;

[0038] (4) Adjust the pH value of the alcohol precipitation paste to 5.5, and use a macroporous resin column for adsorption, and the flow rate of the upper liquid is 2BV / h for adsorption, and the tail liquid is collected; then, it is eluted with 50% ethanol, and the amount of eluent is 2BV, The flow rate is 1.5BV / h, the elua...

Embodiment 3

[0042] Preparation of Acanthopanax extract composition:

[0043] (1) crushing: the roots and stems of Acanthopanax senticosus are crushed to make crushed material;

[0044] (2) Add 5 kg of Acanthopanax senticosus crushed material to 10 times the amount of water to reflux and extract three times, each time for 2 hours, filter the combined filtrate, and concentrate under reduced pressure at 60 ° C to a concentrated paste with a relative density of 1.10;

[0045] (3) Add ethanol until the alcohol content reaches 85%, let it stand for 12 hours, filter and collect the filtrate, recover the ethanol under reduced pressure, and obtain the alcohol precipitated paste;

[0046] (4) Adjust the pH value of the alcohol precipitation paste to 6.0, and use a macroporous resin column for adsorption, and the flow rate of the upper liquid is 2BV / h for adsorption, and the tail liquid is collected; then, it is eluted with 65% ethanol, and the amount of eluent is 2BV, The flow rate is 1.5BV / h, the...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and in particular relates to a composition of Acanthopanax senticosus extract and its extraction method, as well as a method for preparing Acanthopanax acanthopanax injection, the components of which include fructose, glucose, sucrose, maltose, chlorogenic acid, cryptochrom Ortho-acid, neochlorogenic acid, eleutheroside B and eleutheroside E, the preparation method of which is to extract and ethanol-precipitate the medicinal materials of eleuthero, absorb with macroporous adsorption resin, and elute with ethanol at a certain concentration As a result, the eleuthero acanthopanax composition is used for treating diseases of the cardiovascular system.

Description

technical field [0001] The invention relates to an acanthopanax extract, in particular to a composition, an extraction method and a preparation method of the acanthopanax extract. Background technique [0002] Acanthopanax is the dry root, rhizome or stem of Acanthopanax senticosus (Rupr. et Maxim.) Harms, a plant of the family Araliaceae. It is mainly distributed in Heilongjiang, Jilin, Liaoning, Hebei and Shanxi. It is pungent and slightly bitter , warm in nature, returns to the spleen, kidney, heart meridian, has the effect of invigorating qi and invigorating the spleen, tonifying the kidney and calming the nerves. [0003] Modern pharmacological studies have shown that Acanthopanax has the functions of protecting the central nervous system and cardiovascular and cerebrovascular systems, anti-tumor, anti-aging, anti-radiation, and enhancing the body's immunity, especially in the treatment of ischemic stroke. Acanthopanax contains more active ingredients, mainly including...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/254A61K9/08A61K47/02A61P9/10A61P29/00A61K125/00A61K135/00
CPCA61K36/254A61K9/0019A61K9/08A61K47/02A61P9/10A61P29/00A61K2236/15A61K2236/331A61K2236/55
Inventor 方同华闫久江陈玉梅葛一蒙康宁姚洪艳韩冰佟美鸿王博董丽丽赵涛夏迎迎
Owner HARBIN ZHENBAO PHARMA
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