A kind of valacyclovir hydrochloride liposome tablet and preparation method thereof
A technology of valacyclovir hydrochloride and valacyclovir lipid, which is applied in the field of preparation of valacyclovir hydrochloride liposome tablets, can solve problems such as unfavorable stability of valacyclovir hydrochloride, and achieve good tabletability and stability The effect of good resistance and good disintegration performance
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Embodiment 1
[0023] A preparation method of valacyclovir hydrochloride liposome tablet, comprising the following steps:
[0024] (1) Preparation of valacyclovir hydrochloride liposomes: Weigh 1 g of valacyclovir hydrochloride, 1 g of cholesterol and 8 g of soybean lecithin and dissolve them in a mixed solution of dichloromethane and methanol with a volume ratio of 3:1 , and then remove the solvent under vacuum at 60 °C on a rotary evaporator to obtain a thin film, and continue to evaporate for 2 hours to completely remove all traces of solvent and obtain a dry film; the dry film is added at 45 °C with an appropriate amount of 6g polyethylene. Pyrrolidone-K30 was hydrated in 20 mL of phosphate buffer for 15 minutes to obtain a liposome solution; the obtained liposomes were sonicated for 5 minutes to obtain small and uniform vesicles, and the obtained dried lipids were lyophilized The body powder was sieved through an 80-mesh sieve and stored at 4°C until use;
[0025] (2) Mixing: 1 g of li...
Embodiment 2
[0028] A preparation method of valacyclovir hydrochloride liposome tablet, comprising the following steps:
[0029] (1) Preparation of valacyclovir hydrochloride liposomes: Weigh 1 g of valacyclovir hydrochloride, 1 g of cholesterol and 8 g of soybean lecithin and dissolve them in a mixed solution of dichloromethane and methanol with a volume ratio of 3:1 , and then remove the solvent under vacuum at 60 °C on a rotary evaporator to obtain a thin film, and continue to evaporate for 2 hours to completely remove all traces of solvent and obtain a dry film; the dry film is added at 45 °C with an appropriate amount of 6g polyethylene. Pyrrolidone-K30 was hydrated in 20 mL of phosphate buffer for 15 minutes to obtain a liposome solution; the obtained liposomes were sonicated for 5 minutes to obtain small and uniform vesicles, and the obtained dried lipids were lyophilized The body powder was sieved through an 80-mesh sieve and stored at 4°C until use;
[0030] (2) Mixing: 1 g of li...
Embodiment 3
[0033] A preparation method of valacyclovir hydrochloride liposome tablet, comprising the following steps:
[0034] (1) Preparation of valacyclovir hydrochloride liposomes: Weigh 1 g of valacyclovir hydrochloride, 1 g of cholesterol and 8 g of soybean lecithin and dissolve them in a mixed solution of dichloromethane and methanol with a volume ratio of 3:1 , and then remove the solvent under vacuum at 60 °C on a rotary evaporator to obtain a thin film, and continue to evaporate for 2 hours to completely remove all traces of solvent and obtain a dry film; the dry film is added at 45 °C with an appropriate amount of 6g polyethylene. Pyrrolidone-K30 was hydrated in 20 mL of phosphate buffer for 15 minutes to obtain a liposome solution; the obtained liposomes were sonicated for 5 minutes to obtain small and uniform vesicles, and the obtained dried lipids were lyophilized The body powder was sieved through an 80-mesh sieve and stored at 4°C until use;
[0035](2) Mixing: 1 g of lip...
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