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Slow-release multi-crosslinking hydrogel dressing as well as preparation method and application thereof

A cross-linked hydrogel, slow-release technology, applied in medical science, bandages, etc., can solve the problems of difficulty in maintaining, prolonging the wound recovery period, and failing to replenish nutrients needed for wound recovery in time, making it easier to maintain the structure. , the effect of accelerating wound healing

Active Publication Date: 2021-01-12
天晴干细胞股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention is to solve the problem that the physical properties of the existing hydrogel dressing are unstable before and after use, difficult to maintain, and the nutrients required for wound recovery cannot be replenished in time, resulting in wound To solve the problem of prolonged recovery period, a slow-release multi-crosslinked hydrogel dressing and its preparation method and application are provided

Method used

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  • Slow-release multi-crosslinking hydrogel dressing as well as preparation method and application thereof
  • Slow-release multi-crosslinking hydrogel dressing as well as preparation method and application thereof
  • Slow-release multi-crosslinking hydrogel dressing as well as preparation method and application thereof

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specific Embodiment approach 1

[0036] Specific embodiment one: The hydrogel dressing used for wound repair in this embodiment includes a first gel layer, a second gel layer and a third gel layer; wherein the first gel layer is calcium alginate gel layer, the second gel layer is a carboxymethyl chitosan gel layer, and the third gel layer is a methacrylated carboxymethyl chitosan gel layer; the second gel layer is located in the first On the gel layer, on the top of the second gel layer and the sides of the first gel layer and the second gel layer are covered with a third gel layer.

specific Embodiment approach 2

[0037] Specific embodiment two: the preparation method of hydrogel dressing of the present embodiment, comprises the following steps:

[0038] 1. The aqueous solution of carboxymethyl chitosan with a mass concentration of 1.2% to 1.5% and the aqueous solution of methacrylic anhydride with a mass concentration of 1.9% to 2.2% are continuously stirred and reacted for 24 to 26 hours under alkaline and ice bath conditions , followed by vacuum drying to obtain methacrylated carboxymethyl chitosan, which was stored at -80°C;

[0039]2. Mix the sodium alginate aqueous solution and the sPL solution to obtain the mixed solution A, then pour the mixed solution A into the mold and freeze for 30-60 minutes, then add the pre-cooled calcium chloride aqueous solution into the frozen mold, the height is not Pass the mixed solution A, continue to cross-link at 4°C, the cross-linking time is 20-40min, and obtain the first gel layer, which is the calcium alginate gel layer;

[0040] 3. Mix the ...

specific Embodiment approach 3

[0044] Specific embodiment three: the difference between this embodiment and specific embodiment two is: in step one, the volume ratio of carboxymethyl chitosan aqueous solution and methacrylic anhydride aqueous solution is 1: (1.2~1.3). Others are the same as in the second embodiment.

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Abstract

The invention discloses a slow-release multi-crosslinking hydrogel dressing as well as a preparation method and application thereof, and relates to the field of wound repair materials, in particular to a hydrogel dressing as well as a preparation method and application thereof. The invention aims to solve the problems that the physical properties of the existing hydrogel dressing are unstable anddifficult to maintain before and after use, and nutrient substances required by wound recovery cannot be supplemented in time, so that the wound recovery period is prolonged. The dressing comprises afirst gel layer, a second gel layer and a third gel layer. The method comprises the following steps of preparing the first gel layer, preparing the second gel layer on the first gel layer, and preparing the third gel layer on the first gel layer and the second gel layer. The three layers of gel of the hydrogel dressing are matched, the structure is easier to maintain, and the physical property isstable before and after use. Growth factors needed by wound recovery are provided, wound healing is accelerated, the long-acting and slow-release effects are achieved, and the validity period is as long as 20 days. The dressing is used for promoting wound repair.

Description

technical field [0001] The invention relates to the field of wound repair materials, in particular to a hydrogel dressing and its preparation method and application. Background technique [0002] The traditional view is that wound healing requires a dry environment and oxygen. Dry and clean wounds are conducive to wound healing. Generally, traditional gauze dressings or direct exposure of the wound are used, which is the principle of dry healing. But in fact, the use of oxygen by humans requires the oxygenation of hemoglobin, and atmospheric oxygen cannot be directly utilized by wounds. Dry healing also has many disadvantages and deficiencies, including easy dehydration of the wound, forming scabs, and hindering the crawling of epithelial cells; traditional dressings are easy to adhere to the new granulation tissue of the wound, which will be damaged again when the dressing is changed, causing wound pain and slow healing speed ; Rapid leakage requires frequent dressing chan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0023A61L26/0014A61L26/0066A61L2300/10A61L2300/404A61L2300/602C08L5/04C08L5/08C08L29/04
Inventor 张海娇张怡刘春香马德美刘艳青
Owner 天晴干细胞股份有限公司
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