A kind of multifunctional aerogel dressing for promoting wound healing and preparation method thereof
An airgel and multi-functional technology, applied in bandages, medical science, etc., can solve problems such as difficult to effectively promote complex wound healing and repair, and single function of wound dressing, so as to speed up healing and promote regeneration.
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Embodiment 1
[0037] Embodiment 1, the preparation of multifunctional airgel wound dressing
[0038]This embodiment relates to a multifunctional airgel dressing that promotes complex wound healing, the airgel is composed of glutamic acid derivatives, arginine-tryptophan-arginine-tryptophan-arginine - Tryptophan hexapeptide derivatives and hyaluronic acid are co-assembled through hydrogen bonding between amino acid amide bonds, and hydrogen bonding between amino acid carboxyl groups and hyaluronic acid hydroxyl groups.
[0039] Synthetic steps of glutamic acid derivatives: add L-glutamic acid methyl ester hydrochloride (2.94g, 13.9mmol) into dichloromethane (10mL) and stir, then add triethylamine (4.0mL, 29.15mmol) dropwise. Under ice bath, 1,4-phthaloyl chloride (1.30 g, 6.4 mmol) was dissolved in dichloromethane (10 mL) and added dropwise to the above solution, the ice bath was removed, the reaction was stirred at room temperature for 24 hours, and the solvent was removed by rotary evapo...
Embodiment 2
[0043] Example 2, hyaluronic acid-based multifunctional airgel wound dressing promotes cell regeneration and wound healing
[0044] This example uses a multifunctional airgel dressing for the glutamic acid derivatives, arginine-tryptophan-arginine-tryptophan-arginine-tryptophan hexapeptide derivatives prepared in the foregoing example 1 It is co-assembled with hyaluronic acid under the hydrogen bond between the amino acid amide bond and the hydrogen bond between the amino acid carboxyl group and the hyaluronic acid hydroxyl group. Blank polystyrene culture plates were used as control materials.
[0045] Add 50 μL of the clarified solution prepared by the method in Example 1 to each well of a 96-well cell culture plate, cool to room temperature to form a hydrogel, and then dry it in a freeze dryer for 2-3 days to obtain deposited on the bottom of the 96-well plate. Multifunctional airgel dressing.
[0046] 2.1 Multifunctional airgel dressing promotes the proliferation of no...
Embodiment 3
[0058] Example 3 , Preparation of chitosan-based multifunctional airgel wound dressing
[0059] This embodiment relates to a multifunctional airgel dressing that promotes complex wound healing. The airgel is composed of phenylalanine derivatives (molecular formula see Figure 9 ), tryptophan-tryptophan-arginine-tryptophan-arginine-tryptophan hexapeptide derivatives (molecular formula see Figure 10 a) It is co-assembled with chitosan through the hydrogen bond between amino acid amide bonds, and the hydrogen bond between amino acid carboxyl and chitosan hydroxyl.
[0060] Synthetic steps of phenylalanine derivatives: L-phenylalanine methyl ester hydrochloride (3.00g, 13.9mmol) was added into dichloromethane (10mL) and stirred, then triethylamine (4.0mL, 29.15mmol) was added dropwise ). Under ice bath, dissolve 1,4-cyclohexane dichloride (1.33g, 6.4mmol) in dichloromethane (10mL) and add dropwise to the above solution, remove the ice bath, stir and react at room temperature ...
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