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Application of mTOR inhibitor and anti-cancer drug

A technology of anti-cancer drugs and kinase inhibitors, which is applied in the field of combined use of mTOR inhibitors and anti-cancer drugs, can solve problems such as toxic side effects and drug resistance, achieve inhibition of proliferation, enhancement of inhibitory activity, and wide application value Effect

Pending Publication Date: 2021-02-02
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] PTX has a lethal effect on a variety of head and neck tumors. However, long-term administration of PTX at normal doses will lead to obvious toxic and side effects and drug resistance, which limits the clinical application of PTX.

Method used

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  • Application of mTOR inhibitor and anti-cancer drug
  • Application of mTOR inhibitor and anti-cancer drug
  • Application of mTOR inhibitor and anti-cancer drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The salivary gland adenoid cystic carcinoma cell SACC-LM of the present invention is cryopreserved in the laboratory, conventionally cultivated in DMEM / HighGlucose complete culture medium [containing calf serum 10% (volume fraction), penicillin 10% 5 U / L, streptomycin 100mg / L].

[0032] Such as figure 1 As shown, the composition of PKD1 mediated mTOR inhibitor and anticancer drug provided by the present invention and its application

[0033] S101, Western blot detection of PKD1 expression in different adenocarcinoma cell lines;

[0034] S102, CCK8 detects the inhibitory rate of different concentrations of PTX on the adenocarcinoma cell line SACC-LM cells;

[0035] S103, CCK8 detect the inhibitory rate of RAD001 and PTX acting separately / combinedly on SACC-LM cells

[0036] S104, Western blot detection of PKD1 phosphorylation, activation and expression of RAD001 and PTX separately / cooperatively in SACC-LM cells

[0037] S105, Western blot detection of the expression of...

Embodiment 2

[0094] Take RAD001 and PTX, suitable filling agent, after mixing, prepare capsules.

Embodiment 3

[0096] Take RAD001 and PTX, appropriate fillers, binders, and lubricants to prepare granules.

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Abstract

The invention provides application of a composition of an mTOR kinase inhibitor and an anti-cancer drug in preparation of a product for treating adenoid cystic carcinoma or resisting adenoid cystic carcinoma cells. Research finds that the combined treatment mode can improve the sensitivity and specificity to cancer treatment, provides a brand-new visual angle for clinical treatment and plays a more important role, so that the combined treatment mode has wide application value.

Description

technical field [0001] The invention belongs to the technical field of treatment of salivary gland adenoid cystic carcinoma, and in particular relates to the combined use of mTOR inhibitors and anticancer drugs. Background technique [0002] Salivary Adenoid Cystic Carcinoma (SACC) is one of the most common salivary gland epithelial-derived malignant tumors in the oral and maxillofacial region (references: Anderson JN, Jr., Beenken SW, Crowe R, Soong SJ , Peters G, Maddox WA, et al. Prognostic factors in minor salivary gland cancer [J]. Head Neck, 1995; 17:480-6). Salivary gland adenoid cystic carcinoma has the characteristics of slow growth but strong invasiveness, early expansion along nerve and vascular bundles to distant places, and the biological characteristics of easy recurrence and high metastasis (5-year lung metastasis rate is as high as 50%), These make the prognosis of patients with salivary gland adenoid cystic carcinoma poor, and the long-term survival rate is...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/436A61K31/337A61P35/00
CPCA61K45/06A61K31/436A61K31/337A61P35/00A61K2300/00
Inventor 陈娇吕蝶王利伟陈红利崔博淼康颖竹张平冯云
Owner SICHUAN UNIV