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Hippocampus preparation, preparation method thereof and application of hippocampus preparation

A hippocampal and preparation technology, applied in the field of medicine, can solve the problems of limited pharmacological activity, high price, unfavorable adjustment, etc., and achieve the effects of broad clinical application prospects, high safety, and high degree of recognition.

Pending Publication Date: 2021-02-05
厦门市健康医疗大数据中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For a long time, hippocampus has been used as a traditional and precious marine traditional Chinese medicine, but because of its high price, the exploration of its pharmacological activity has been limited.
However, there is no report on the hippocampus for glucose and lipid metabolism disorders
In addition, the clinical application of hippocampus usually uses sun-dried products, which are easy to deteriorate during storage, affect the efficacy of the medicine, and even produce toxicity, and are not conducive to dispensing.

Method used

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  • Hippocampus preparation, preparation method thereof and application of hippocampus preparation
  • Hippocampus preparation, preparation method thereof and application of hippocampus preparation
  • Hippocampus preparation, preparation method thereof and application of hippocampus preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation of embodiment 1 hippocampus freeze-dried powder

[0039] Take 260g of freshly cultured hippocampus, slaughter and remove the viscera, wash and drain the water, crush it into appropriate small pieces of tissue with a meat grinder, and completely crush it with a tissue homogenizer to prepare hippocampus tissue homogenate. The obtained homogenate Weight 215g. Put 215g of hippocampus tissue homogenate into an ultra-low temperature refrigerator or liquid nitrogen to freeze quickly, control the thickness of the frozen block at about 1cm, freeze-dry for 36 hours after being completely frozen, and crush the obtained freeze-dried hippocampus at low temperature to obtain 48g of freeze-dried powder. The product yield is 22.32%.

Embodiment 2

[0040] The preparation of embodiment 2 hippocampus freeze-dried powder

[0041] Take 270g of fresh and live hippocampus, slaughter, remove the viscera, wash, drain and weigh 222g, then put it into an ultra-low temperature refrigerator or liquid nitrogen for quick freezing, and freeze-dry it for 72 hours after it is completely frozen. 52 g of freeze-dried powder were prepared by low-temperature pulverization, and the dry product yield was 23.42%.

Embodiment 3

[0042] The effect of embodiment 3 hippocampus lyophilized powder preparation on type 2 diabetes mellitus (T2DM) mouse body weight

[0043]Experimental animals: 48 C57BL / 6J mice, male, weighing 20±2g, purchased from Jiangsu Jicui Experimental Animal Co., Ltd.

[0044] Experimental reagents and drugs: the freeze-dried hippocampus powder prepared by the method described in the above-mentioned example 1 or example 2 can be used. In this example, the freeze-dried hippocampus powder prepared in example 2 is mainly used, and the appropriate concentration is prepared with distilled water before use. suspension.

[0045] Mouse diabetes model replication, experimental grouping and administration: All experimental mice were fed adaptively for one week, and randomly divided into 8 blank control groups (NC) and 40 model-making groups. The model group was fed with high-calorie feed (60% feed imported from D12492) for 8 weeks, and the blank control group was fed with ordinary feed (6% of no...

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Abstract

The invention discloses a hippocampus preparation, a preparation method thereof and application of the hippocampus preparation. According to the invention, hippocampus freeze-dried powder convenient to clinically apply is prepared by employing related techniques of freeze drying and the like, and compared with a sun-dried product, the hippocampus freeze-dried powder has the characteristics that the drug effect and nutritional ingredients in a hippocampus are well preserved, and the hippocampus freeze-dried powder is convenient to store, blend and take. Through further research, the invention further finds that glycolipid metabolism disorder related diseases can be effectively prevented and improved by oral administration of the hippocampus freeze-dried powder, new indications are added forclinical application of traditional Chinese medicine hippocampus, the clinical application range of the hippocampus is widened, and huge social benefits and economic benefits will be generated in thefields of modernization of traditional chinese medicine, health, medical treatment and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the preparation and application of traditional Chinese medicine hippocampus. Background technique [0002] Hippocampus (Latin scientific name: hippocampus) is an animal of the genus Hippocampus of the family Telesauridae of the chordate phylum. It is a traditional precious Chinese medicinal material in my country and is known as "Southern Ginseng". It has the effects of warming the kidney and strengthening yang, benefiting essence seeds, relieving cough and relieving asthma, promoting blood circulation and unblocking the veins, dispelling stagnation and reducing swelling, and is mainly used to treat all syndromes caused by deficiency of kidney yang. The main clinical effects of hippocampus recorded in the 2020 edition of "Chinese Pharmacopoeia" are "warming the kidney and strengthening yang, reducing swelling and dispelling stagnation". [0003] For a long time, hippocampus has ...

Claims

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Application Information

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IPC IPC(8): A61K35/60A61K9/19A61P3/10A61P3/04A61P1/16A61P3/06A61P5/50A23L2/38A23L33/10A23G3/36A21D13/06A21D2/34
CPCA61K35/60A61K9/19A61P3/10A61P3/04A61P1/16A61P3/06A61P5/50A23L2/38A23L33/10A23G3/364A21D13/06A21D2/34A23V2002/00
Inventor 许光辉万慧琪郑乐云
Owner 厦门市健康医疗大数据中心
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