Hippocampus preparation, preparation method thereof and application of hippocampus preparation

A hippocampal and preparation technology, applied in the field of medicine, can solve the problems of limited pharmacological activity, high price, unfavorable adjustment, etc., and achieve the effects of broad clinical application prospects, high safety, and high degree of recognition.

Pending Publication Date: 2021-02-05
厦门市健康医疗大数据中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For a long time, hippocampus has been used as a traditional and precious marine traditional Chinese medicine, but because of its high price, the exploration of its pharmacological activity has been limited.
However, there is no report on the hippocampus for glu

Method used

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  • Hippocampus preparation, preparation method thereof and application of hippocampus preparation
  • Hippocampus preparation, preparation method thereof and application of hippocampus preparation
  • Hippocampus preparation, preparation method thereof and application of hippocampus preparation

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0038] The preparation of embodiment 1 hippocampus freeze-dried powder

[0039] Take 260 g of live cultured hippocampus, slaughter, remove the internal organs, wash and drain the water, use a meat grinder to break into appropriate small pieces of tissue, and use a tissue homogenizer to completely break it to prepare a hippocampal tissue homogenate. The obtained homogenate Weight 215g. Put 215 g of hippocampal tissue homogenate into an ultra-low temperature refrigerator or liquid nitrogen for rapid freezing, the thickness of the frozen block is controlled at about 1 cm, freeze-dried for 36 hours after being completely frozen, and the obtained freeze-dried hippocampus is pulverized at low temperature to obtain 48 g of freeze-dried powder. The product yield was 22.32%.

Example Embodiment

[0040] The preparation of embodiment 2 hippocampus freeze-dried powder

[0041] Take 270g of fresh seahorse, slaughter, remove the internal organs, wash, drain and weigh to 222g, then put it into an ultra-low temperature refrigerator or liquid nitrogen for quick freezing, freeze-dry it completely for 72 hours, and freeze-dry it completely. 52 g of freeze-dried powder was prepared by low-temperature pulverization, and the yield of the dry product was 23.42%.

Example Embodiment

[0042] Example 3 The effect of hippocampal freeze-dried powder preparation on the body weight of type 2 diabetes mellitus (T2DM) mice

[0043]Experimental animals: C57BL / 6J mice, 48, male, weighing 20±2 g, purchased from Jiangsu Jicui Experimental Animal Co., Ltd.

[0044] Experimental reagents and medicines: the hippocampus freeze-dried powder prepared by the method described in the above-mentioned Example 1 or Example 2 can be used. In this example, the hippocampus freeze-dried powder prepared in Example 2 is mainly used, and it is prepared with distilled water to an appropriate concentration before use. of the suspension.

[0045] Mouse diabetes model replication, experimental grouping and administration: All experimental mice were adaptively reared for one week, and randomly divided into 8 blank control groups (NC) and 40 modeling groups. The modeling group was fed with high-calorie feed (feed imported from D12492 with a fat content of 60%) for 8 weeks, and the blank cont...

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Abstract

The invention discloses a hippocampus preparation, a preparation method thereof and application of the hippocampus preparation. According to the invention, hippocampus freeze-dried powder convenient to clinically apply is prepared by employing related techniques of freeze drying and the like, and compared with a sun-dried product, the hippocampus freeze-dried powder has the characteristics that the drug effect and nutritional ingredients in a hippocampus are well preserved, and the hippocampus freeze-dried powder is convenient to store, blend and take. Through further research, the invention further finds that glycolipid metabolism disorder related diseases can be effectively prevented and improved by oral administration of the hippocampus freeze-dried powder, new indications are added forclinical application of traditional Chinese medicine hippocampus, the clinical application range of the hippocampus is widened, and huge social benefits and economic benefits will be generated in thefields of modernization of traditional chinese medicine, health, medical treatment and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the preparation and application of traditional Chinese medicine hippocampus. Background technique [0002] Hippocampus (Latin scientific name: hippocampus) is an animal of the genus Hippocampus of the family Telesauridae of the chordate phylum. It is a traditional precious Chinese medicinal material in my country and is known as "Southern Ginseng". It has the effects of warming the kidney and strengthening yang, benefiting essence seeds, relieving cough and relieving asthma, promoting blood circulation and unblocking the veins, dispelling stagnation and reducing swelling, and is mainly used to treat all syndromes caused by deficiency of kidney yang. The main clinical effects of hippocampus recorded in the 2020 edition of "Chinese Pharmacopoeia" are "warming the kidney and strengthening yang, reducing swelling and dispelling stagnation". [0003] For a long time, hippocampus has ...

Claims

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Application Information

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IPC IPC(8): A61K35/60A61K9/19A61P3/10A61P3/04A61P1/16A61P3/06A61P5/50A23L2/38A23L33/10A23G3/36A21D13/06A21D2/34
CPCA61K35/60A61K9/19A61P3/10A61P3/04A61P1/16A61P3/06A61P5/50A23L2/38A23L33/10A23G3/364A21D13/06A21D2/34A23V2002/00
Inventor 许光辉万慧琪郑乐云
Owner 厦门市健康医疗大数据中心
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