Unlock instant, AI-driven research and patent intelligence for your innovation.

A photoactivated tea saponin cellulose nanomaterial and its preparation method and application

A technology of tea saponin and nanomaterials, applied in the field of medicine, to achieve mild reaction conditions, improve stability, and facilitate industrial production

Active Publication Date: 2021-09-21
SOUTH CHINA UNIV OF TECH
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Linking cellulose with tea saponin and ruthenium pyridine complex to construct a new compound can exert the synergistic effect of the three to form a relatively stable light-activated antibacterial material. There has been no report on this aspect of research

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A photoactivated tea saponin cellulose nanomaterial and its preparation method and application
  • A photoactivated tea saponin cellulose nanomaterial and its preparation method and application
  • A photoactivated tea saponin cellulose nanomaterial and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Mix 5g of o-phenanthroline and 5g of potassium bromide, add 60g of concentrated sulfuric acid and concentrated nitric acid mixture (volume ratio 2:1), heat to 80°C and reflux for 4h, cool to room temperature, and pour the mixture into 120mL of water , add saturated sodium hydroxide solution to adjust the solution to neutral, filter, and extract the filtrate with 600 mL of chloroform, and evaporate the solvent from the extract to obtain product 1 (5.8 g).

[0048] (2) Dissolve 5g of product 1, 5g of o-carboxybenzaldehyde, and 50g of ammonium acetate in 600g of glacial acetic acid, heat to 80°C and reflux for 4h, cool to room temperature, pour the mixture into 3000mL of water, add ammonia water to adjust the solution to neutral , filtered to retain the precipitate as product 2 (8.2 g).

[0049] (3) Mix 5g of o-phenanthroline with 5g of lithium chloride and 5g of ruthenium trichloride, add 45g of dimethylamide, heat to 120°C for reflux reaction for 6h, add acetone unti...

Embodiment 2

[0055] (1) Mix 5g of o-phenanthroline and 7.5g of potassium bromide, add 100g of concentrated sulfuric acid and concentrated nitric acid mixture (volume ratio 1:1), heat to 110°C and reflux for 2h, cool to room temperature, and pour the mixture into 500mL of water , add saturated sodium hydroxide solution to adjust the solution to neutral, filter, and extract the filtrate with 500 mL of chloroform, and evaporate the solvent from the extract to obtain product 1 (5.6 g).

[0056] (2) Dissolve 5 g of product 1, 2.5 g of o-carboxybenzaldehyde, and 100 g of ammonium acetate in 538 g of glacial acetic acid, heat to 120°C and reflux for 2 hours, cool to room temperature, pour the mixture into 1100 mL of water, add ammonia water to adjust the solution to medium After filtration, the precipitate was retained as product 2 (8.5 g).

[0057] (3) Mix 5g of o-phenanthroline with 2.5g of lithium chloride and 2.5g of ruthenium trichloride, add 60g of dimethylamide, heat to 150°C for reflux re...

Embodiment 3

[0063] (1) Mix 5g of o-phenanthroline and 6g of potassium bromide, add 80g of concentrated sulfuric acid and concentrated nitric acid mixture (volume ratio 3:1), heat to 100°C and reflux for 3h, cool to room temperature, pour the mixture into 250mL of water, Add saturated sodium hydroxide solution to adjust the solution to neutral, filter, and extract the filtrate with 750 mL of chloroform, and evaporate the solvent from the extract to obtain product 1 (5.3 g).

[0064] (2) Dissolve 5 g of product 1, 1.7 g of o-carboxybenzaldehyde, and 40 g of ammonium acetate in 380 g of glacial acetic acid, heat to 100°C and reflux for 3 hours, cool to room temperature, pour the mixture into 1200 mL of water, and add ammonia water to adjust the solution to medium and filtered to retain the precipitate as product 2 (7.5 g).

[0065] (3) Mix 5g of o-phenanthroline with 1.7g of lithium chloride and 1.7g of ruthenium trichloride, add 42g of dimethylamide, heat to 140°C for reflux reaction for 4h...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention discloses a light-activated theasapogenin cellulose nanometer material, a preparation method and application thereof. The method comprises: oxidizing o-phenanthroline with mixed acid to obtain 1,10-o-phenanthroline-5,6-dione, and reacting o-carboxybenzaldehyde and ammonium acetate to obtain 2-(2-carboxyphenyl)imidazo [4,5‑f]‑1,10-phenanthroline; o-phenanthroline and ruthenium can be combined under the action of lithium chloride to form o-phenanthroline ruthenium complex, and then connected with the above product to obtain phenanthrolinophenyl Imidazole ruthenium complex; cellulose and N-tert-butoxycarbonylglycine generate glycine-cellulose ester under the action of a catalyst, and then connect with phenanthrolinophenylimidazole ruthenium complex to generate glycine-cellulose ester and phenanthroline ruthenium Finally, the amino group of the complex reacts with the theasapogenin aldehyde group to generate the photoactivated theasapogenin cellulose nanometer material. The material has anti-drug-resistant bacteria activity under blue light irradiation, and can be used as an antibacterial auxiliary material or a drug carrier.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a photoactivated theasapogenin cellulose nanometer material and its preparation method and application. Background technique [0002] Due to the abuse of antibiotics, more and more drug-resistant bacteria have caused a great threat to human health. In order to solve the above problems, people are working hard to develop alternatives to antibiotics. Natural products contain a large number of active ingredients, which have inhibitory effects on bacteria, and bacteria are not easy to develop tolerance to them, so natural products are an important source of antibiotic substitutes. [0003] Tea saponin is the active ingredient in tea seeds, which has antibacterial and fungal effects (Huang Weiwen et al., Research on the antibacterial effect of camellia saponin, Economic Forest Research, 2002, 20 (1): 17-19), but compared with tea saponin Low antibacterial activity of antibiotics. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08B15/06A61K41/00A61K47/61A61K31/56A61P31/04
CPCA61K31/56A61K41/0042A61K41/0057A61K47/61A61P31/04C08B15/06A61K2300/00
Inventor 叶勇刘泽宇黄传庆
Owner SOUTH CHINA UNIV OF TECH