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FURIN gene DNA methylation marker and detection kit thereof

A technology of methylation mark and kit, applied in the field of biomedicine

Active Publication Date: 2021-02-05
SUZHOU UNIV
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Problems solved by technology

However, there is no report of a suitable site as an intervention target for the prevention and control of hypertension.

Method used

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  • FURIN gene DNA methylation marker and detection kit thereof
  • FURIN gene DNA methylation marker and detection kit thereof

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Embodiment 1

[0026] A population study (including 2312 residents without cardiovascular disease) found that the systolic blood pressure, diastolic blood pressure and mean arterial pressure of the population with low levels of furin were higher than those with high levels of furin; and in the population without hypertension, low levels of furin ( The lowest quartile level group) the risk of hypertension was 1.46 times that of the high level group (highest quartile level group) (P=0.003). The results of this study suggest that FURIN protein deficiency may be the cause of hypertension. However, the molecular mechanism of FURIN deficiency associated with hypertension is still unclear. However, the study of the molecular mechanism of FURIN involved in the pathogenesis of hypertension will help Discovery of drug targets against FURIN deficiency to facilitate the prevention and control of hypertension. As a media connecting genes and the environment, DNA methylation regulates the expression and f...

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Abstract

The invention discloses an FURIN gene DNA methylation marker and a detection kit thereof, and belongs to the technical field of biological medicines. The DNA methylation marker provided by the invention is a DNA methylation site Chr15: 91416118 of an FURIN gene promoter region, and the methylation degree of the DNA methylation marker indicates the recurrence risk of hypertension of a subject. TheFURIN gene DNA methylation marker provided by the invention can be used for predicting the recurrence risk of hypertension, provides a basis for screening of hypertension high-risk groups, and can also be used as an intervention target for preventing and controlling hypertension. Explaining that FURIN lacks of a molecular mechanism acting on the hypertension is facilitated, and important epidemiological evidences can be provided for FURIN gene methylation as a drug target for preventing and controlling hypertension.

Description

technical field [0001] The invention relates to a FURIN gene DNA methylation marker and a detection kit thereof, belonging to the technical field of biomedicine. Background technique [0002] Hypertension is not only a cardiovascular disease, but also an important risk factor for many other cardiovascular and cerebrovascular diseases. Globally, 67% of heart disease, 54% of stroke are caused by high blood pressure, and 13.5% of deaths are attributed to high blood pressure. The global prevalence of hypertension in adults is about 30%. At present, there are about 330 million hypertensive patients in my country, accounting for about 1 / 3 of the global hypertensive patients. Therefore, high blood pressure has become an important public health problem in our country and seriously threatens human health. How to effectively prevent and control high blood pressure is a major public health challenge facing our country at present. Find and discover more potential risk factors and inter...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12Q1/6858C12N15/11
CPCC12Q1/6883C12Q1/6858C12Q2600/154C12Q2523/125C12Q2521/301C12Q2565/627
Inventor 张明芝何艳彭浩
Owner SUZHOU UNIV
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